Paper · 30680
Topical effects of 16,16 dimethyl prostaglandin E2 on gastric acid secretion and mucosal permeability to hydrogen ions in dogs.
Cheung LY and 3 others. Gut, 1978. Cited by 20 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Topical effects of 16,16 dimethyl prostaglandin E2 on gastric acid secretion and mucosal permeability to hydrogen ions in dogs. Papers, record 30680. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30680
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Topical effects of 16,16 dimethyl prostaglandin E2 on gastric acid secretion and mucosal permeability to hydrogen ions in dogs.
- PubMed
Topics11
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Gastric Juice | Major topic |
| Gastric Mucosa | Major topic |
| Prostaglandins E, Synthetic | Major topic |
| Animals | |
| Cell Membrane Permeability | |
| Depression, Chemical | |
| Dogs | |
| Histamine | |
| Hydrogen-Ion Concentration | |
| Secretory Rate | |
| Sodium |
Source PubMed
Grants0
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
None in this release.
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References8
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 1,158,077 | Effects of an orally administered prostaglandin analogue (16, 16-dimethyl prostaglandin E2) on human gastric secretion. | Gastroenterology | 1975 | https://conductscience.org/library/papers/1158077 | PubMed |
| 2 | 13,667 | Founder's lecture: New concepts of the gastric mucosal barrier. | Am J Surg | 1977 | https://conductscience.org/library/papers/13667 | PubMed |
| 3 | 14,343,747 | EFFECTS OF GLYCINE AND OTHER INSTILLATES ON CONCENTRATION OF GASTRIC ACID. | Am J Physiol | 1965 | https://conductscience.org/library/papers/14343747 | PubMed |
| 4 | 174,967 | Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. | Gastroenterology | 1976 | https://conductscience.org/library/papers/174967 | PubMed |
| 5 | 238,904 | Effect of gastric secretory inhibitors on the gastric mucosal barrier. | Gut | 1975 | https://conductscience.org/library/papers/238904 | PubMed |
| 6 | 3,975 | Inhibition of gastric secretion in the dog by 16,16-dimethyl prostaglandin E2. | Am J Physiol | 1976 | https://conductscience.org/library/papers/3975 | PubMed |
| 7 | 4,432,047 | Gastric secretory inhibition by certain methyl analogs of prostaglandin E2 following intestinal administration in man. | Scand J Gastroenterol | 1974 | https://conductscience.org/library/papers/4432047 | PubMed |
| 8 | 4,823,988 | Marked inhibition of gastric secretion by two prostaglandin analogs given orally to man. | Life Sci | 1974 | https://conductscience.org/library/papers/4823988 | PubMed |
Cited by7
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 20 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 7,379,677 | Effects of 16, 16-dimethyl prostaglandin E2 methyl ester on aspirin-and indomethacin-induced gastrointestinal lesions in dogs. | Dig Dis Sci | 1980 | https://conductscience.org/library/papers/7379677 | PubMed |
| 7,040,000 | A comparison of the effects of prostacyclin and the 15(S), 15-methyl analogs of PGE2 and PGF2-alpha on gastric parietal and nonparietal secretion. | Dig Dis Sci | 1982 | https://conductscience.org/library/papers/7040000 | PubMed |
| 6,861,595 | 16,16-dimethyl PGE2 and HCO3- efflux. | Dig Dis Sci | 1983 | https://conductscience.org/library/papers/6861595 | PubMed |
| 6,861,594 | Topical 16,16-dimethyl-prostaglandin E2. Effects on gastric morphology, hydrogen ion loss, and bicarbonate secretion. | Dig Dis Sci | 1983 | https://conductscience.org/library/papers/6861594 | PubMed |
| 6,796,678 | Stimulated gastric prostaglandin output, and the effect of inhibition of prostaglandin synthetase, in the conscious cat. | J Physiol | 1981 | https://conductscience.org/library/papers/6796678 | PubMed |
| 3,125,802 | Gastric mucosal blood flow in misoprostol pretreated aspirin-induced ulceration. | Ann Surg | 1988 | https://conductscience.org/library/papers/3125802 | PubMed |
| 2,743,842 | Prostaglandin protection against hemorrhage-induced gastric stress ulceration in the rat. | Dig Dis Sci | 1989 | https://conductscience.org/library/papers/2743842 | PubMed |
Genes0
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None in this release.
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None in this release.
Data0
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Data dates
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- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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