Paper · 308698

Tumor-promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors.

Lee LS and 1 other. Science, 1978. Cited by 386 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Tumor-promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors. Papers, record 308698. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/308698

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Tumor-promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors.; PubMed
Journal: Science; PubMed
Year: 1978; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/308698/; PubMed
DOI: https://doi.org/10.1126/science.308698; PubMed
The journal: https://conductscience.org/library/journal-index/0404511; PubMed
Citations, by iCite: 386; iCite
Relative citation ratio, by iCite: 9.81; iCite
Revised in PubMed: 2019-06-18; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Lee LS	L S
2	Weinstein IB	I B

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Epidermal Growth Factor	Major topic
Peptides	Major topic
Phorbol Esters	Major topic
Phorbols	Major topic
Receptors, Drug	Major topic
Binding, Competitive
Cell Membrane
HeLa Cells
Kinetics
Tetradecanoylphorbol Acetate

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by73

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 386 citations.

PMID	Title	Journal	Year	In Papers	Source
34,572,058	Epidermal Growth Factor Receptor Expression in the Corneal Epithelium.	Cells	2021	https://conductscience.org/library/papers/34572058	PubMed
22,358,873	Recent developments in the structure, function and regulation of platelet-derived growth factor and its receptors.	Cytotechnology	1989	https://conductscience.org/library/papers/22358873	PubMed
16,068,160	Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors.	Nature	1979	https://conductscience.org/library/papers/16068160	PubMed
15,530,851	Retinoids arrest breast cancer cell proliferation: retinoic acid selectively reduces the duration of receptor tyrosine kinase signaling.	Exp Cell Res	2004	https://conductscience.org/library/papers/15530851	PubMed
8,400,459	Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factor.	Mol Biol Cell	1993	https://conductscience.org/library/papers/8400459	PubMed
8,381,655	Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro.	Br J Cancer	1993	https://conductscience.org/library/papers/8381655	PubMed
8,161,236	Stimulation of NADPH-dependent reactive oxygen species formation and DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat peritoneal lavage cells.	Arch Environ Contam Toxicol	1994	https://conductscience.org/library/papers/8161236	PubMed
7,400,219	Phorbol myristate acetate stimulates pinocytosis and membrane spreading in mouse peritoneal macrophages.	J Cell Biol	1980	https://conductscience.org/library/papers/7400219	PubMed
7,306,026	Effects of retinoids and phorbol esters on the sensitivity of different cell lines to the polypeptide toxins modeccin, abrin, ricin and diphtheria toxin.	Biochem J	1981	https://conductscience.org/library/papers/7306026	PubMed
7,193,044	Effect of 12-O-tetradecanoylphorbol-13-acetate on two charateristics of transformation acquired sequentially by ENU-exposed rat brain cells.	Br J Cancer	1980	https://conductscience.org/library/papers/7193044	PubMed

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
EGF	1,950	PubTator's text mining	https://conductscience.org/library/genes/1950

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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