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Paper · 308989

Long-term culture of human antigen-specific cytotoxic T-cell lines.

Gillis S and 3 others. J Exp Med, 1978. Cited by 248 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Long-term culture of human antigen-specific cytotoxic T-cell lines. Papers, record 308989. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/308989

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Long-term culture of human antigen-specific cytotoxic T-cell lines.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
248
iCite
Relative citation ratio, by iCite
4.9
iCite
Revised in PubMed
2019-05-08
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Gillis SS
2Baker PEP E
3Ruscetti FWF W
4Smith KAK A

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AntigensMajor topic
Cell LineMajor topic
Cytotoxicity, ImmunologicMajor topic
T-LymphocytesMajor topic
Antigens, Surface
Blood Preservation
Cell Survival
Freezing
Humans
Rosette Formation

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References11

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
169,003In vitro generation of tumor-specific cytotoxic lymphocytes. Secondary allogeneic mixed tumor lymphocyte culture of normal murine spleen cells.J Exp Med1977https://conductscience.org/library/papers/69003PubMed
2206,705Expression of an antigen associated with acute lymphoblastic leukemia in human leukemia-lymphoma cell lines.J Natl Cancer Inst1978https://conductscience.org/library/papers/206705PubMed
3141,483Functional and morphologic characterization of human T cells continuously grown in vitro.J Immunol1977https://conductscience.org/library/papers/141483PubMed
4145,543Long term culture of tumour-specific cytotoxic T cells.Nature1977https://conductscience.org/library/papers/145543PubMed
5305,461Autologous leukemia-specific T-cell-mediated lymphocytotoxicity in patients with acute myelogenous leukemia.J Exp Med1978https://conductscience.org/library/papers/305461PubMed
6308,439Cloned T-cell lines with specific cytolytic activity.Curr Top Microbiol Immunol1978https://conductscience.org/library/papers/308439PubMed
7307,029T cell growth factor: parameters of production and a quantitative microassay for activity.J Immunol1978https://conductscience.org/library/papers/307029PubMed
8301,573A non-T, non-B human leukemia cell line (NALM-1): establishment of the cell line and presence of leukemia-associated antigens.J Natl Cancer Inst1977https://conductscience.org/library/papers/301573PubMed
91,085,418Separation of suppressor and killer T cells by surgace phenotype.Nature1976https://conductscience.org/library/papers/1085418PubMed
10181,845Selective in vitro growth of T lymphocytes from normal human bone marrows.Science1976https://conductscience.org/library/papers/181845PubMed

1 to 10 of 11

See all 11 references

Cited by56

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 248 citations.

PMIDTitleJournalYearIn PapersSource
40,702,342Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes.EMBO Rep2025https://conductscience.org/library/papers/40702342PubMed
39,333,474CD38 in SLE CD4 T cells promotes Ca2+ flux and suppresses interleukin-2 production by enhancing the expression of GM2 on the surface membrane.Nat Commun2024https://conductscience.org/library/papers/39333474PubMed
39,204,319Stimulating the Antitumor Immune Response Using Immunocytokines: A Preclinical and Clinical Overview.Pharmaceutics2024https://conductscience.org/library/papers/39204319PubMed
39,086,690Cancer immunotherapies: A hope for the uncurable?Front Mol Med2023https://conductscience.org/library/papers/39086690PubMed
38,003,826Viremia and Inflammatory Cytokines in Dengue: Interleukin-2 as a Biomarker of Infection, and Interferon-α and -γ as Markers of Primary versus Secondary Infection.Pathogens2023https://conductscience.org/library/papers/38003826PubMed
35,551,655Development of Cancer Immunotherapies.Cancer Treat Res2022https://conductscience.org/library/papers/35551655PubMed
34,303,065Generation of Tumor-activated T cells Using Electroporation.Bioelectrochemistry2021https://conductscience.org/library/papers/34303065PubMed
30,092,847Epigenetic modification of mesenchymal stromal cells enhances their suppressive effects on the Th17 responses of cells from rheumatoid arthritis patients.Stem Cell Res Ther2018https://conductscience.org/library/papers/30092847PubMed
29,677,473Signaling and Function of Interleukin-2 in T Lymphocytes.Annu Rev Immunol2018https://conductscience.org/library/papers/29677473PubMed
29,666,307Interleukin-2 shapes the cytotoxic T cell proteome and immune environment-sensing programs.Sci Signal2018https://conductscience.org/library/papers/29666307PubMed

1 to 10 of 56

See all 56 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
IL23,558PubTator's text mininghttps://conductscience.org/library/genes/3558

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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