Paper · 3108398

Mitogen-driven B cell proliferation and differentiation are not accompanied by hypermutation of immunoglobulin variable region genes.

Manser T. J Immunol, 1987. Cited by 53 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mitogen-driven B cell proliferation and differentiation are not accompanied by hypermutation of immunoglobulin variable region genes. Papers, record 3108398. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3108398

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Mitogen-driven B cell proliferation and differentiation are not accompanied by hypermutation of immunoglobulin variable region genes.; PubMed
Journal: J Immunol; PubMed
Year: 1987; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/3108398/; PubMed
The journal: https://conductscience.org/library/journal-index/2985117R; PubMed
Citations, by iCite: 53; iCite
Relative citation ratio, by iCite: 0.93; iCite
Revised in PubMed: 2007-11-14; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Manser T	T

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
B-Lymphocytes	Major topic
Immunoglobulin Heavy Chains	Major topic
Immunoglobulin Variable Region	Major topic
Animals
Cell Differentiation
Lymphocyte Activation
Mice
Mitogens
Mutation
Time Factors

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
A123739	PHS HHS	United States		PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 53 citations.

PMID	Title	Journal	Year	In Papers	Source
25,288,395	Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.	J Exp Med	2014	https://conductscience.org/library/papers/25288395	PubMed
24,879,790	Binding of AID to DNA does not correlate with mutator activity.	J Immunol	2014	https://conductscience.org/library/papers/24879790	PubMed
19,202,055	The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.	Proc Natl Acad Sci U S A	2009	https://conductscience.org/library/papers/19202055	PubMed
16,418,396	AID-dependent histone acetylation is detected in immunoglobulin S regions.	J Exp Med	2006	https://conductscience.org/library/papers/16418396	PubMed
16,157,688	AID from bony fish catalyzes class switch recombination.	J Exp Med	2005	https://conductscience.org/library/papers/16157688	PubMed
15,605,247	Mutational activity in cell line WEHI-231.	Immunogenetics	2005	https://conductscience.org/library/papers/15605247	PubMed
12,633,669	Class-switch recombination: after the dawn of AID.	Curr Opin Immunol	2003	https://conductscience.org/library/papers/12633669	PubMed
11,854,365	Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation.	J Exp Med	2002	https://conductscience.org/library/papers/11854365	PubMed
10,092,799	Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.	J Immunol	1999	https://conductscience.org/library/papers/10092799	PubMed
8,436,910	Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.	J Exp Med	1993	https://conductscience.org/library/papers/8436910	PubMed

1 to 10 of 17

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data23

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession	Source
GENBANK	M17032	GENBANK
GENBANK	M17033	GENBANK
GENBANK	M17034	GENBANK
GENBANK	M17035	GENBANK
GENBANK	M17036	GENBANK
GENBANK	M17037	GENBANK
GENBANK	M17038	GENBANK
GENBANK	M17039	GENBANK
GENBANK	M17040	GENBANK
GENBANK	M17041	GENBANK

1 to 10 of 23

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Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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