Paper31110285

IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria.

de Menezes MN and 10 others. Sci Rep, 2019. Cited by 23 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria. Papers, record 31110285. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/31110285

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria.; PubMed
Journal: Sci Rep; PubMed
Year: 2019; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/31110285/; PubMed
DOI: https://doi.org/10.1038/s41598-019-44125-2; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC6527574/; PubMed
The journal: https://conductscience.org/library/journal-index/101563288; PubMed
Citations, by iCite: 23; iCite
Relative citation ratio, by iCite: 1.03; iCite
Revised in PubMed: 2021-01-09; PubMed

Authors11

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	de Menezes MN	Maria Nogueira
2	Salles ÉM	Érika Machado
3	Vieira F	Flávia
4	Amaral EP	Eduardo Pinheiro
5	Zuzarte-Luís V	Vanessa	https://orcid.org/0000-0003-0023-5953
6	Cassado A	Alexandra
7	Epiphanio S	Sabrina
8	Alvarez JM	José Maria
9	Alves-Filho JC	José Carlos	https://orcid.org/0000-0002-9918-8714
10	Mota MM	Maria Manuel
11	D'Império-Lima MR	Maria Regina	https://orcid.org/0000-0002-4683-7709

Source PubMed

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Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Inflammation	Major topic
Interleukin-1alpha	Major topic
Liver	Major topic
Malaria	Major topic
Plasmodium chabaudi	Major topic
Animals
Male
Mice, Inbred C57BL
Necrosis
Tumor Necrosis Factor-alpha

Source PubMed

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References50

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	24,453,977	Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.	PLoS Pathog	2014	https://conductscience.org/library/papers/24453977	PubMed
2	19,706,490	Heme oxygenase-1 affords protection against noncerebral forms of severe malaria.	Proc Natl Acad Sci U S A	2009	https://conductscience.org/library/papers/19706490	PubMed
3	27,926,944	Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice.	PLoS Pathog	2016	https://conductscience.org/library/papers/27926944	PubMed
4	21,523,780	A clinical perspective of IL-1β as the gatekeeper of inflammation.	Eur J Immunol	2011	https://conductscience.org/library/papers/21523780	PubMed
5	22,444,631	Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.	Immunity	2012	https://conductscience.org/library/papers/22444631	PubMed
6	23,988,520	Mice lacking inducible nitric oxide synthase develop exacerbated hepatic inflammatory responses induced by Plasmodium berghei NK65 infection.	Microbes Infect	2013	https://conductscience.org/library/papers/23988520	PubMed
7	22,673,309	Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese.	Genes Immun	2012	https://conductscience.org/library/papers/22673309	PubMed
8	10,858,230	Plasmodium chabaudi-infected erythrocytes adhere to CD36 and bind to microvascular endothelial cells in an organ-specific way.	Infect Immun	2000	https://conductscience.org/library/papers/10858230	PubMed
9	22,017,443	Comparative histopathology of mice infected with the 17XL and 17XNL strains of Plasmodium yoelii.	J Parasitol	2012	https://conductscience.org/library/papers/22017443	PubMed
10	26,022,690	Interleukin-1α deficiency attenuates endoplasmic reticulum stress-induced liver damage and CHOP expression in mice.	J Hepatol	2015	https://conductscience.org/library/papers/26022690	PubMed
11	29,366,909	Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation.	J Hepatol	2018	https://conductscience.org/library/papers/29366909	PubMed
12	27,019,056	Malarial hepatopathy: Clinical profile and association with other malarial complications.	Acta Trop	2016	https://conductscience.org/library/papers/27019056	PubMed
13	23,572,518	Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.	J Biol Chem	2013	https://conductscience.org/library/papers/23572518	PubMed
14	25,629,406	IL-1α signaling is critical for leukocyte recruitment after pulmonary Aspergillus fumigatus challenge.	PLoS Pathog	2015	https://conductscience.org/library/papers/25629406	PubMed
15	21,191,096	Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system.	Toxicol Pathol	2010	https://conductscience.org/library/papers/21191096	PubMed
16	18,691,550	Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis.	Cancer Cell	2008	https://conductscience.org/library/papers/18691550	PubMed
17	28,504,245	Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.	Cell Mol Immunol	2018	https://conductscience.org/library/papers/28504245	PubMed
18	22,188,297	The role of the spleen in malaria.	Cell Microbiol	2012	https://conductscience.org/library/papers/22188297	PubMed
19	1,898,902	CD4+ and CD8+ T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS.	Infect Immun	1991	https://conductscience.org/library/papers/1898902	PubMed
20	10,469,263	Up-regulation of cytokines in glomerulonephritis associated with murine malaria infection.	Int J Exp Pathol	1999	https://conductscience.org/library/papers/10469263	PubMed

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Cited by15

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 23 citations.

PMID	Title	Journal	Year	In Papers	Source
40,917,784	Morphometric analysis and immunobiological investigation of Indigofera oblongifolia on the infected lung with Plasmodium chabaudi.	Open Life Sci	2025	https://conductscience.org/library/papers/40917784	PubMed
40,453,956	Differential expression of TLR and CXCR genes in mammary HC11 cells challenged with Bacillus cereus and Bacillus subtilis: Implications for mastitis resistance.	Vet World	2025	https://conductscience.org/library/papers/40453956	PubMed
38,469,182	Urtica pilulifera leaves extract mitigates cadmium induced hepatotoxicity via modulation of antioxidants, inflammatory markers and Nrf-2 signaling in mice.	Front Mol Biosci	2024	https://conductscience.org/library/papers/38469182	PubMed
38,453,916	Malaria blood stage infection suppresses liver stage infection via host-induced interferons but not hepcidin.	Nat Commun	2024	https://conductscience.org/library/papers/38453916	PubMed
38,299,836	The intersection of host in vivo metabolism and immune responses to infection with kinetoplastid and apicomplexan parasites.	Microbiol Mol Biol Rev	2024	https://conductscience.org/library/papers/38299836	PubMed
38,274,822	Exposure to common infections may shape basal immunity and potentially HIV-1 acquisition amongst a high-risk population in Coastal Kenya.	Front Immunol	2023	https://conductscience.org/library/papers/38274822	PubMed
38,257,341	Screening of Multitarget Compounds against Acetaminophen Hepatic Toxicity Using In Silico, In Vitro, and In Vivo Approaches.	Molecules	2024	https://conductscience.org/library/papers/38257341	PubMed
37,812,650	Cellular iron governs the host response to malaria.	PLoS Pathog	2023	https://conductscience.org/library/papers/37812650	PubMed
36,717,945	Genome-wide liver transcriptomic profiling of a malaria mouse model reveals disturbed immune and metabolic responses.	Parasit Vectors	2023	https://conductscience.org/library/papers/36717945	PubMed
35,702,995	MicroRNAs: master regulators in host-parasitic protist interactions.	Open Biol	2022	https://conductscience.org/library/papers/35702995	PubMed
34,790,829	Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines.	J Immunol Res	2021	https://conductscience.org/library/papers/34790829	PubMed
34,607,466	Metabolomic Analysis of Diverse Mice Reveals Hepatic Arginase-1 as Source of Plasma Arginase in Plasmodium chabaudi Infection.	mBio	2021	https://conductscience.org/library/papers/34607466	PubMed
33,672,278	Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?	Cells	2021	https://conductscience.org/library/papers/33672278	PubMed
33,570,721	Inadvertent nucleotide sequence alterations during mutagenesis: highlighting the vulnerabilities in mouse transgenic technology.	J Genet Eng Biotechnol	2021	https://conductscience.org/library/papers/33570721	PubMed
32,599,864	Mediterranean Diet: Lipids, Inflammation, and Malaria Infection.	Int J Mol Sci	2020	https://conductscience.org/library/papers/32599864	PubMed

Show 9 more cited byShow fewer cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
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NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
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ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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