Paper · 31301

Saxitoxin binding to the mammalian sodium channel. Competition by monovalent and divalent cations.

Weigele JB and 1 other. FEBS Lett, 1978. Cited by 53 papers, by iCite.

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ConductScience Library. Saxitoxin binding to the mammalian sodium channel. Competition by monovalent and divalent cations. Papers, record 31301. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/31301

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Saxitoxin binding to the mammalian sodium channel. Competition by monovalent and divalent cations.; PubMed
Journal: FEBS Lett; PubMed
Year: 1978; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/31301/; PubMed
DOI: https://doi.org/10.1016/0014-5793(78)80049-0; PubMed
The journal: https://conductscience.org/library/journal-index/0155157; PubMed
Citations, by iCite: 53; iCite
Relative citation ratio, by iCite: 1.59; iCite
Revised in PubMed: 2019-06-20; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Weigele JB	J B
2	Barchi RL	R L

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cations, Monovalent	Major topic
Ion Channels	Major topic
Saxitoxin	Major topic
Animals
Binding, Competitive
Cations, Divalent
Fishes
Hydrogen-Ion Concentration
Kinetics
Olfactory Nerve
Osmolar Concentration
Rats
Species Specificity
Synaptosomes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 53 citations.

PMID	Title	Journal	Year	In Papers	Source
23,008,436	Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.	J Gen Physiol	2012	https://conductscience.org/library/papers/23008436	PubMed
16,432,696	Beta1-subunit modulates the Nav1.4 sodium channel by changing the surface charge.	Exp Brain Res	2006	https://conductscience.org/library/papers/16432696	PubMed
12,719,231	Tonic and phasic guanidinium toxin-block of skeletal muscle Na channels expressed in Mammalian cells.	Biophys J	2003	https://conductscience.org/library/papers/12719231	PubMed
8,874,004	Use dependence of tetrodotoxin block of sodium channels: a revival of the trapped-ion mechanism.	Biophys J	1996	https://conductscience.org/library/papers/8874004	PubMed
8,384,241	Divalent cation competition with [3H]saxitoxin binding to tetrodotoxin-resistant and -sensitive sodium channels. A two-site structural model of ion/toxin interaction.	J Gen Physiol	1993	https://conductscience.org/library/papers/8384241	PubMed
8,011,896	Permeation of Na+ through open and Zn(2+)-occupied conductance states of cardiac sodium channels modified by batrachotoxin: exploring ion-ion interactions in a multi-ion channel.	Biophys J	1994	https://conductscience.org/library/papers/8011896	PubMed
6,286,124	Batrachotoxinin-A 20-alpha-benzoate: a new radioactive ligand for voltage sensitive sodium channels.	Cell Mol Neurobiol	1981	https://conductscience.org/library/papers/6286124	PubMed
6,246,486	Purification from rat sarcolemma of the saxitoxin-binding component of the excitable membrane sodium channel.	Proc Natl Acad Sci U S A	1980	https://conductscience.org/library/papers/6246486	PubMed
6,096,479	Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins.	J Gen Physiol	1984	https://conductscience.org/library/papers/6096479	PubMed
2,540,849	Influence of negative surface charge on toxin binding to canine heart Na channels in planar bilayers.	Biophys J	1989	https://conductscience.org/library/papers/2540849	PubMed

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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