Paper · 318583

Effect of graded amounts of acid instilled into the duodenum on pancreatic bicarbonate secretion and plasma secretin in duodenal ulcer patients and normal subjects.

Isenberg JI and 2 others. Gastroenterology, 1977. Cited by 53 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Effect of graded amounts of acid instilled into the duodenum on pancreatic bicarbonate secretion and plasma secretin in duodenal ulcer patients and normal subjects. Papers, record 318583. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/318583

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Effect of graded amounts of acid instilled into the duodenum on pancreatic bicarbonate secretion and plasma secretin in duodenal ulcer patients and normal subjects.; PubMed
Journal: Gastroenterology; PubMed
Year: 1977; PubMed
Publication types: Clinical Trial, Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/318583/; PubMed
The journal: https://conductscience.org/library/journal-index/0374630; PubMed
Citations, by iCite: 53; iCite
Relative citation ratio, by iCite: 2.87; iCite
Revised in PubMed: 2018-11-30; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Isenberg JI	J I
2	Cano R	R
3	Bloom SR	S R

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Bicarbonates	Major topic
Duodenal Ulcer	Major topic
Hydrochloric Acid	Major topic
Pancreas	Major topic
Secretin	Major topic
Adult
Clinical Trials as Topic
Dose-Response Relationship, Drug
Duodenum
Humans
Middle Aged

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 53 citations.

PMID	Title	Journal	Year	In Papers	Source
7,097,601	Plasma secretion and pancreatic secretion in response to liver extract meal with varied pH and exogenous secretin in the dog.	J Physiol	1982	https://conductscience.org/library/papers/7097601	PubMed
6,884,815	Duodenal ulcer: does pathophysiology equal aetiology?	Gut	1983	https://conductscience.org/library/papers/6884815	PubMed
6,165,534	Pancreatic exocrine secretion and immunoreactive secretin release after intraduodenal instillation of 1-phenyl-1-hydroxy-n-pentane and HCl in rats.	Dig Dis Sci	1981	https://conductscience.org/library/papers/6165534	PubMed
6,104,568	Radioimmunoassay of secretin. A critical review and current status.	Dig Dis Sci	1980	https://conductscience.org/library/papers/6104568	PubMed
907,397	Acid and endocrine responses to meals varying in pH in normal and duodenal ulcer subjects.	Ann Surg	1977	https://conductscience.org/library/papers/907397	PubMed
710,821	Bioassay of cholecystokinin in the duodenal mucosa.	Gastroenterol Jpn	1978	https://conductscience.org/library/papers/710821	PubMed
516,778	Endocrinology of duodenal ulcer.	World J Surg	1979	https://conductscience.org/library/papers/516778	PubMed
516,754	Radioimmunoassay of gastrointestinal hormones.	World J Surg	1979	https://conductscience.org/library/papers/516754	PubMed
399,608	Pathophysiology of gastrin and secretin.	J Clin Pathol Suppl (Assoc Clin Pathol)	1978	https://conductscience.org/library/papers/399608	PubMed
31,087	Plasma secretin concentrations in fasting and postprandial state in man.	Am J Dig Dis	1978	https://conductscience.org/library/papers/31087	PubMed

1 to 10 of 13

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
SCT	6,343	PubTator's text mining	https://conductscience.org/library/genes/6343

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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