Paper · 32043983

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury.

Russell CD and 2 others. Lancet, 2020. Cited by 1,329 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Papers, record 32043983. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/32043983

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury.; PubMed
Journal: Lancet; PubMed
Year: 2020; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/32043983/; PubMed
DOI: https://doi.org/10.1016/s0140-6736(20)30317-2; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC7134694/; PubMed
The journal: https://conductscience.org/library/journal-index/2985213R; PubMed
Citations, by iCite: 1,329; iCite
Relative citation ratio, by iCite: 73.1; iCite
Revised in PubMed: 2025-05-30; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Russell CD	Clark D
2	Millar JE	Jonathan E
3	Baillie JK	J Kenneth

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Betacoronavirus	Major topic
Coronavirus Infections	Major topic
Glucocorticoids	Major topic
Pneumonia, Viral	Major topic
COVID-19
Evidence-Based Medicine
Humans
SARS-CoV-2
COVID-19 Drug Treatment

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
MC_PC_19059	Medical Research Council	United Kingdom		PubMed

Source PubMed

Trials10

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

Trial	Title	The trial lists it as	Source
NCT04273529	The Efficacy and Safety of Thalidomide in the Adjuvant Treatment of Moderate New Coronavirus (COVID-19) Pneumonia	Background	ClinicalTrials.gov
NCT04273581	The Efficacy and Safety of Thalidomide Combined With Low-dose Hormones in the Treatment of Severe COVID-19	Background	ClinicalTrials.gov
NCT04349592	Hydroxychloroquine With or Without Azithromycin for Virologic Cure of COVID-19	Background	ClinicalTrials.gov
NCT04355247	Prophylactic Corticosteroid to Prevent COVID-19 Cytokine Storm	Background	ClinicalTrials.gov
NCT04380870	Describing Chinese Herbal Medicine Telehealth Care for Symptoms Related to Infectious Diseases Such as COVID-19	Background	ClinicalTrials.gov
NCT04540926	Cyclosporine A Plus Low-steroid Treatment in COVID-19 Pneumonia	Results	ClinicalTrials.gov
NCT04654416	Clinical Outcome of Patients With COVID-19 Pneumonia Treated With Corticosteroids and Colchicine	Background	ClinicalTrials.gov
NCT05226754	Study Design of the Diacerein in Patients With Covid-19	Results	ClinicalTrials.gov
NCT05819918	Calcifediol in the Treatment of COVID 19	Background	ClinicalTrials.gov
NCT06084351	Phase 3 Open-Label Controlled Trial of Convalescent Plasma in Early COVID-19 Infection	Background	ClinicalTrials.gov

Comments and corrections3

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers	Source
Comment in	32,122,468	On the use of corticosteroids for 2019-nCoV pneumonia.	https://conductscience.org/library/papers/32122468	PubMed
Comment in	32,321,620	Corticosteroid use for 2019-nCoV infection: A double-edged sword.	https://conductscience.org/library/papers/32321620	PubMed
Comment in	32,536,610	Contrasting evidence for corticosteroid treatment for coronavirus-induced cytokine storm.	https://conductscience.org/library/papers/32536610	PubMed

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	15,494,274	Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients.	J Clin Virol	2004	https://conductscience.org/library/papers/15494274	PubMed
2	18,504,331	Use of corticosteroids in treating infectious diseases.	Arch Intern Med	2008	https://conductscience.org/library/papers/18504331	PubMed
3	15,486,852	Factors associated with psychosis among patients with severe acute respiratory syndrome: a case-control study.	Clin Infect Dis	2004	https://conductscience.org/library/papers/15486852	PubMed
4	19,926,983	Hemodynamic impact of a positive end-expiratory pressure setting in acute respiratory distress syndrome: importance of the volume status.	Crit Care Med	2010	https://conductscience.org/library/papers/19926983	PubMed
5	28,177,862	Middle East Respiratory Syndrome.	N Engl J Med	2017	https://conductscience.org/library/papers/28177862	PubMed
6	30,917,856	The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis.	Crit Care	2019	https://conductscience.org/library/papers/30917856	PubMed
7	16,195,357	Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome.	Clin Chem	2005	https://conductscience.org/library/papers/16195357	PubMed
8	32,007,143	Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.	Lancet	2020	https://conductscience.org/library/papers/32007143	PubMed
9	12,781,536	Lung pathology of fatal severe acute respiratory syndrome.	Lancet	2003	https://conductscience.org/library/papers/12781536	PubMed
10	29,161,116	Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome.	Am J Respir Crit Care Med	2018	https://conductscience.org/library/papers/29161116	PubMed

1 to 10 of 21

See all 21 references

Cited by1,131

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,329 citations.

PMID	Title	Journal	Year	In Papers	Source
42,872,126	Human β defensin type 2 based novel antimicrobial peptide prediction using both molecular dynamics simulation and artificial intelligence methods.	Front Chem	2026	https://conductscience.org/library/papers/42872126	PubMed
42,136,112	Induced Regulatory T Cells Attenuate Poly I:C-Triggered Acute Lung Injury by Modulating Cytokine Responses.	J Immunol Res	2026	https://conductscience.org/library/papers/42136112	PubMed
41,859,055	Impact of Dexamethasone on Respiratory Sequelae in the Follow-Up of Hospitalized Patients with Sars-Cov-2 Pneumonia.	Infect Drug Resist	2026	https://conductscience.org/library/papers/41859055	PubMed
41,600,815	Elements of Viral Outbreak Preparedness: Lessons, Strategies, and Future Directions.	Viruses	2025	https://conductscience.org/library/papers/41600815	PubMed
41,408,194	COVID-19 treatment of hospital patients worldwide at the onset of the pandemic in 2020: a systematic review.	BMC Infect Dis	2025	https://conductscience.org/library/papers/41408194	PubMed
41,400,072	The Differential Effects of Immunosuppressants on Hepatitis E Virus Replication and the Triggered Inflammatory Responses in Macrophages.	J Viral Hepat	2026	https://conductscience.org/library/papers/41400072	PubMed
41,287,854	Unveiling the clinical profiles of critically ill COVID-19 patients: insights from Ezhou during the early spread.	PeerJ	2025	https://conductscience.org/library/papers/41287854	PubMed
41,225,361	Early low-dose dexamethasone is associated with shorter acute symptom duration in Chikungunya virus infection: a retrospective cohort study.	BMC Infect Dis	2025	https://conductscience.org/library/papers/41225361	PubMed
40,927,847	Deep Vein Thrombosis in Critically Ill Patients With COVID-19 Pneumonia: Incidence, Wells Score Diagnostic Performance, and Hospital Prognosis.	J Ultrasound Med	2026	https://conductscience.org/library/papers/40927847	PubMed
40,634,102	Therapeutic Mechanisms of Traditional Kampo Medicines in the Management of Mild COVID-19 through Gut Microbiota Modulation.	Intern Med	2026	https://conductscience.org/library/papers/40634102	PubMed

1 to 10 of 1,131

See all 1,131 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs2

The drugs whose trials, in the Pipelines release, list the paper.

Drug	ChEMBL ID	The trials list it as	Trials	In Drugs and targets	Source
CYCLOSPORINE	CHEMBL160	Results	1	https://conductscience.org/library/drugs/CHEMBL160	ChEMBL
DIACEREIN	CHEMBL41286	Results	1	https://conductscience.org/library/drugs/CHEMBL41286	ChEMBL

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/32043983

GET https://conductscience.org/api/papers/v1/32043983/references?page=2

API reference For AI assistants