Paper · 3213

Properties of the tetrodotoxin binding component in plasma membranes isolated from Electrophorus electricus.

Reed JK and 1 other. Biochemistry, 1976. Cited by 122 papers, by iCite.

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ConductScience Library. Properties of the tetrodotoxin binding component in plasma membranes isolated from Electrophorus electricus. Papers, record 3213. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3213

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Properties of the tetrodotoxin binding component in plasma membranes isolated from Electrophorus electricus.; PubMed
Journal: Biochemistry; PubMed
Year: 1976; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/3213/; PubMed
DOI: https://doi.org/10.1021/bi00650a002; PubMed
The journal: https://conductscience.org/library/journal-index/0370623; PubMed
Citations, by iCite: 122; iCite
Relative citation ratio, by iCite: 3.08; iCite
Revised in PubMed: 2019-06-12; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Reed JK	J K
2	Raftery MA	M A

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Electric Organ	Major topic
Receptors, Drug	Major topic
Tetrodotoxin	Major topic
Animals
Binding Sites
Binding, Competitive
Cations, Monovalent
Electrophorus
Hydrogen-Ion Concentration
Kinetics
Mathematics
Organ Specificity
Osmolar Concentration
Protein Binding
Sodium Chloride
Species Specificity

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by39

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 122 citations.

PMID	Title	Journal	Year	In Papers	Source
40,768,348	Critical role of extracellular loops in differential modulations of TTX-sensitive and TTX-resistant Nav channels.	Proc Natl Acad Sci U S A	2025	https://conductscience.org/library/papers/40768348	PubMed
39,103,479	Structural biology and molecular pharmacology of voltage-gated ion channels.	Nat Rev Mol Cell Biol	2024	https://conductscience.org/library/papers/39103479	PubMed
38,394,191	Identification and In-Silico study of non-synonymous functional SNPs in the human SCN9A gene.	PLoS One	2024	https://conductscience.org/library/papers/38394191	PubMed
38,033,122	A structural atlas of druggable sites on Nav channels.	Channels (Austin)	2024	https://conductscience.org/library/papers/38033122	PubMed
37,274,073	Endoscopic ultrasound-guided fine-needle aspiration pancreatic adenocarcinoma samples yield adequate DNA for next-generation sequencing: A cohort analysis.	World J Gastroenterol	2023	https://conductscience.org/library/papers/37274073	PubMed
33,143,033	KV11.1, NaV1.5, and CaV1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity.	Int J Mol Sci	2020	https://conductscience.org/library/papers/33143033	PubMed
23,008,436	Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.	J Gen Physiol	2012	https://conductscience.org/library/papers/23008436	PubMed
20,390,102	The tetrodotoxin binding site is within the outer vestibule of the sodium channel.	Mar Drugs	2010	https://conductscience.org/library/papers/20390102	PubMed
16,818,219	Functional expression of "cardiac-type" Nav1.5 sodium channel in canine intracardiac ganglia.	Heart Rhythm	2006	https://conductscience.org/library/papers/16818219	PubMed
11,891,345	An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart.	Proc Natl Acad Sci U S A	2002	https://conductscience.org/library/papers/11891345	PubMed

1 to 10 of 39

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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