Paper · 322145

A protease inhibitor blocks SOS functions in Escherichia coli: antipain prevents lambda repressor inactivation, ultraviolet mutagenesis, and filamentous growth.

Meyn MS and 2 others. Proc Natl Acad Sci U S A, 1977. Cited by 114 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A protease inhibitor blocks SOS functions in Escherichia coli: antipain prevents lambda repressor inactivation, ultraviolet mutagenesis, and filamentous growth. Papers, record 322145. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/322145

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A protease inhibitor blocks SOS functions in Escherichia coli: antipain prevents lambda repressor inactivation, ultraviolet mutagenesis, and filamentous growth.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1977; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/322145/; PubMed
DOI: https://doi.org/10.1073/pnas.74.3.1152; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC430629/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 114; iCite
Relative citation ratio, by iCite: 3.36; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Meyn MS	M S
2	Rossman T	T
3	Troll W	W

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Coliphages	Major topic
Enzyme Inhibitors	Major topic
Escherichia coli	Major topic
Mutation	Major topic
Oligopeptides	Major topic
Papain	Major topic
Carbamates
DNA Repair
Genes
Hot Temperature
Ultraviolet Rays

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	183,109	Infection of UV-irradiated xeroderma pigmentosum fibroblasts by herpes simplex virus: study of capacity and Weigle reactivation.	Mutat Res	1976	https://conductscience.org/library/papers/183109	PubMed
2	240,839	Protease II from Escherichia coli. Purification and characterization.	J Biol Chem	1975	https://conductscience.org/library/papers/240839	PubMed
3	765,722	recA+-dependent inactivation of the lambda repressor in Escherichia coli lysogens by gamma-radiation and by tif expression.	Mol Gen Genet	1975	https://conductscience.org/library/papers/765722	PubMed
4	781,527	Partial suppression of the LexA phenotype by mutations (rnm) which restore ultraviolet resistance but not ultraviolet mutability to Escherichia coli B/r uvr A lexA.	Mutat Res	1976	https://conductscience.org/library/papers/781527	PubMed
5	786,161	Intracellular protein degradation in mammalian and bacterial cells: Part 2.	Annu Rev Biochem	1976	https://conductscience.org/library/papers/786161	PubMed
6	790,393	Prophage lambda induction of Escherichia coli K12 envA uvrB: a highly sensitive test for potential carcinogens.	Proc Natl Acad Sci U S A	1976	https://conductscience.org/library/papers/790393	PubMed
7	795,416	Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.	Bacteriol Rev	1976	https://conductscience.org/library/papers/795416	PubMed
8	1,065,893	Enhancement of postreplication repair in Chinese hamster cells.	Proc Natl Acad Sci U S A	1976	https://conductscience.org/library/papers/1065893	PubMed
9	1,090,931	Proteolytic cleavage of bacteriophage lambda repressor in induction.	Proc Natl Acad Sci U S A	1975	https://conductscience.org/library/papers/1090931	PubMed
10	1,094,463	Model for regulation of Escherichia coli DNA repair functions.	Proc Natl Acad Sci U S A	1975	https://conductscience.org/library/papers/1094463	PubMed

1 to 10 of 37

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Cited by38

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 114 citations.

PMID	Title	Journal	Year	In Papers	Source
39,734,524	Geobacter-associated prophages confer beneficial effect on dissimilatory reduction of Fe(III) oxides.	Fundam Res	2024	https://conductscience.org/library/papers/39734524	PubMed
38,974,320	A pangenome analysis of ESKAPE bacteriophages: the underrepresentation may impact machine learning models.	Front Mol Biosci	2024	https://conductscience.org/library/papers/38974320	PubMed
38,916,438	Interspecies ecological competition rejuvenates decayed Geobacter electroactive biofilm.	ISME J	2024	https://conductscience.org/library/papers/38916438	PubMed
9,255,586	Perspectives in cancer chemoprevention.	Environ Health Perspect	1997	https://conductscience.org/library/papers/9255586	PubMed
7,651,321	A new mutation in Escherichia coli K12, isfA, which is responsible for inhibition of SOS functions.	Mol Gen Genet	1995	https://conductscience.org/library/papers/7651321	PubMed
7,437,293	Inhibiting effects of antipain on urethane-induced lung neoplasia in mice.	Br J Cancer	1980	https://conductscience.org/library/papers/7437293	PubMed
7,412,771	Low molecular weight peptidic fraction in the chromatin from normal and cancer cells: control of transcription.	Mol Biol Rep	1980	https://conductscience.org/library/papers/7412771	PubMed
7,045,585	Proteolytic activities in yeast after UV irradiation. II. Variation in proteinase levels in mutants blocked in DNA-repair pathways.	Mol Gen Genet	1982	https://conductscience.org/library/papers/7045585	PubMed
7,045,584	Proteolytic activities in yeast after UV irradiation I. Variation in proteinase levels in repair proficient Rad+ strains.	Mol Gen Genet	1982	https://conductscience.org/library/papers/7045584	PubMed
6,992,563	Sister chromatid exchange analysis.	Am J Hum Genet	1980	https://conductscience.org/library/papers/6992563	PubMed

1 to 10 of 38

See all 38 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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