Paper · 322146

Interaction between mutations of ribosomes and RNA polymerase: a pair of strA and rif mutants individually temperature-insensitive but temperature-sensitive in combination.

Chakrabarti SL and 1 other. Proc Natl Acad Sci U S A, 1977. Cited by 36 papers, by iCite.

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ConductScience Library. Interaction between mutations of ribosomes and RNA polymerase: a pair of strA and rif mutants individually temperature-insensitive but temperature-sensitive in combination. Papers, record 322146. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/322146

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Interaction between mutations of ribosomes and RNA polymerase: a pair of strA and rif mutants individually temperature-insensitive but temperature-sensitive in combination.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1977; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/322146/; PubMed
DOI: https://doi.org/10.1073/pnas.74.3.1157; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC430631/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 36; iCite
Relative citation ratio, by iCite: 0.86; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Chakrabarti SL	S L
2	Gorini L	L

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
DNA-Directed RNA Polymerases	Major topic
Mutation	Major topic
Ribosomes	Major topic
Temperature	Major topic
Bacterial Proteins
Escherichia coli
Genotype
Phenotype
Ribosomal Proteins
Rifampin
Streptomycin
Transduction, Genetic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,089,639	Growth of bacteriophages MS2 and T7 on streptomycin-resistant mutants of Escherichia coli.	J Bacteriol	1975	https://conductscience.org/library/papers/1089639	PubMed
2	4,885,263	Two compounds implicated in the function of the RC gene of Escherichia coli.	Nature	1969	https://conductscience.org/library/papers/4885263	PubMed
3	11,945,477	Reconstitution of bacterial DNA-dependent RNA-polymerase from isolated subunits as a tool for the elucidation of the role of the subunits in transcription.	FEBS Lett	1970	https://conductscience.org/library/papers/11945477	PubMed
5	1,108,010	Identification of a gene for the alpha-subunit of RNA polymerase at the str-spc region of the Escherichia coli chromosome.	Proc Natl Acad Sci U S A	1975	https://conductscience.org/library/papers/1108010	PubMed
6	1,107,319	Coupling of rates of transcription, translation, and messenger ribonucleic acid degradation in streptomycin-dependent mutants of Escherichia coli.	J Bacteriol	1976	https://conductscience.org/library/papers/1107319	PubMed
7	5,339,604	Effect of ribosomes on the biosynthesis of ribonucleic acid in vitro.	J Mol Biol	1966	https://conductscience.org/library/papers/5339604	PubMed
8	4,869,226	Role of protein factor in the functional binding of ribosomes to natural messenger RNA.	J Mol Biol	1968	https://conductscience.org/library/papers/4869226	PubMed
9	4,943,838	Ribosomal discrimination of tRNAs.	Nat New Biol	1971	https://conductscience.org/library/papers/4943838	PubMed
10	4,920,897	Genetic analysis of streptomycin resistance in Escherichia coli.	Genetics	1970	https://conductscience.org/library/papers/4920897	PubMed
11	1,101,266	New chromosomal location for structural genes of ribosomal proteins.	Proc Natl Acad Sci U S A	1975	https://conductscience.org/library/papers/1101266	PubMed

1 to 10 of 23

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Cited by23

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 36 citations.

PMID	Title	Journal	Year	In Papers	Source
31,137,816	Two Old Dogs, One New Trick: A Review of RNA Polymerase and Ribosome Interactions during Transcription-Translation Coupling.	Int J Mol Sci	2019	https://conductscience.org/library/papers/31137816	PubMed
29,027,901	Structure of RNA polymerase bound to ribosomal 30S subunit.	Elife	2017	https://conductscience.org/library/papers/29027901	PubMed
23,223,236	Isolation and characterization of RNA polymerase rpoB mutations that alter transcription slippage during elongation in Escherichia coli.	J Biol Chem	2013	https://conductscience.org/library/papers/23223236	PubMed
19,629,166	Positive epistasis drives the acquisition of multidrug resistance.	PLoS Genet	2009	https://conductscience.org/library/papers/19629166	PubMed
11,796,329	Evolution of drug resistance in Mycobacterium tuberculosis: clinical and molecular perspective.	Antimicrob Agents Chemother	2002	https://conductscience.org/library/papers/11796329	PubMed
10,852,861	Genetic antagonism and hypermutability in Mycobacterium smegmatis.	J Bacteriol	2000	https://conductscience.org/library/papers/10852861	PubMed
7,883,717	Streptomycin- and rifampin-resistant mutants of Escherichia coli perturb F exclusion of bacteriophage T7 by affecting synthesis of the F plasmid protein PifA.	J Bacteriol	1995	https://conductscience.org/library/papers/7883717	PubMed
7,035,836	An antibiotic dependent conditional lethal mutant with a lesion affecting transcription and translation.	Mol Gen Genet	1981	https://conductscience.org/library/papers/7035836	PubMed
6,783,768	Defective lysis of streptomycin-resistant escherichia coli cells infected with bacteriophage f2.	J Virol	1981	https://conductscience.org/library/papers/6783768	PubMed
6,761,548	Genetic studies on the beta subunit of Escherichia coli RNA polymerase. I. The effect of known, single amino acid substitutions in an essential protein.	Mol Gen Genet	1982	https://conductscience.org/library/papers/6761548	PubMed

1 to 10 of 23

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None in this release.

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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