Paper324671
Synergy, additivism and antagonism in immunosuppression. A critical review.
Berenbaum MC. Clin Exp Immunol, 1977. Cited by 349 papers, by iCite.
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ConductScience Library. Synergy, additivism and antagonism in immunosuppression. A critical review. Papers, record 324671. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/324671
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics8
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Immunosuppressive Agents | Major topic |
| Animals | |
| Antibody Formation | |
| Dose-Response Relationship, Drug | |
| Drug Interactions | |
| Drug Synergism | |
| Drug Therapy, Combination | |
| Humans |
Source PubMed
References28
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 14,315,108 | THE EFFECT OF DELAYED ADMINISTRATION OF FOLINIC ACID ON IMMUNOLOGICAL INHIBITION BY METHOTREXATE. | Immunology | 1965 | https://conductscience.org/library/papers/14315108 | PubMed |
| 2 | 14,217,927 | THE RELATION OF RADIATION DOSAGE TO ENHANCEMENT, DEPRESSION, AND RECOVERY OF THE INITIAL FORSSMAN HEMOLYSIN RESPONSE IN RABBITS. | J Infect Dis | 1964 | https://conductscience.org/library/papers/14217927 | PubMed |
| 3 | 14,189,285 | INDUCTION OF TOLERANCE WITH DISRUPTED ANTIGEN, IMURAN, AND SUBLETHAL IRRADIATION. | Surg Forum | 1964 | https://conductscience.org/library/papers/14189285 | PubMed |
| 4 | 14,158,063 | AZASERINE AND THIOPURINES. I. INHIBITION OF S-180 MOUSE TUMOR AND ANTIBODY SYNTHESIS. | J Lab Clin Med | 1964 | https://conductscience.org/library/papers/14158063 | PubMed |
| 5 | 14,066,954 | ENHANCED SUPPRESSION OF THE SECONDARY IMMUNE RESPONSE BY COMBINATION OF 6-MERCAPTOPURINE DUAZOMYCIN A'. | Nature | 1963 | https://conductscience.org/library/papers/14066954 | PubMed |
| 6 | 13,968,137 | Suppression of the immune response by drugs in combination. | Proc Soc Exp Biol Med | 1962 | https://conductscience.org/library/papers/13968137 | PubMed |
| 8 | 13,465,303 | Antagonisms and antagonists. | Pharmacol Rev | 1957 | https://conductscience.org/library/papers/13465303 | PubMed |
| 13 | 1,099,730 | Enhancement of skin grafts in the mouse. The combined used of specific and nonspecific immunosuppression. | Transplantation | 1975 | https://conductscience.org/library/papers/1099730 | PubMed |
| 14 | 5,770,114 | Enhanced suppression of experimental allergic encephalomyelitis by combination chemotherapy with duazomycin-A and 6-mercaptopurine. | Proc Soc Exp Biol Med | 1969 | https://conductscience.org/library/papers/5770114 | PubMed |
| 15 | 4,144,500 | Combination chemotherapy for clinically established graft-versus-host disease in mice. | Cancer Res | 1973 | https://conductscience.org/library/papers/4144500 | PubMed |
| 16 | 4,380,568 | Quantitative studies on tissue transplantation immunity. 8. The effects of irradiation. | Proc R Soc Lond B Biol Sci | 1966 | https://conductscience.org/library/papers/4380568 | PubMed |
| 17 | 4,353,772 | Enhanced effects of prostaglandin E1 and dibutyryl cyclic AMP upon human lymphocytes in the presence of cortisol. | J Clin Invest | 1973 | https://conductscience.org/library/papers/4353772 | PubMed |
| 18 | 4,226,527 | Immunosuppression by pyrimidine nucleoside analogs. | Biochem Pharmacol | 1966 | https://conductscience.org/library/papers/4226527 | PubMed |
| 19 | 4,590,921 | Synergism of methotrexate with imuran and with 5-fluorouracil and their effects on hemolysin plaque-forming cell production in the mouse. | Cancer Res | 1974 | https://conductscience.org/library/papers/4590921 | PubMed |
| 20 | 4,558,906 | The effect of combined immunosuppressive agents and cell-free antigen on xenograft survival. | Transplantation | 1972 | https://conductscience.org/library/papers/4558906 | PubMed |
| 21 | 4,556,073 | Passive enhancement of kidney allografts: potentiation with antithymocyte serum. | Transplantation | 1972 | https://conductscience.org/library/papers/4556073 | PubMed |
| 22 | 4,717,916 | The effect of microsomal enzyme inhibition on the immunosuppressive and toxic effects of cyclophosphamide. | Clin Exp Immunol | 1973 | https://conductscience.org/library/papers/4717916 | PubMed |
| 23 | 5,031,609 | Therapeutic studies in NZB-W mice. II. Relative efficacy of azathioprine, cyclophosphamide and methylprednisolone. | Arthritis Rheum | 1972 | https://conductscience.org/library/papers/5031609 | PubMed |
| 24 | 5,031,608 | Therapeutic studies in NZB-W mice. I. Synergy of azathioprine, cyclophosphamide and methylprednisolone in combination. | Arthritis Rheum | 1972 | https://conductscience.org/library/papers/5031608 | PubMed |
| 25 | 4,941,150 | Immunological enhancement. | Transplant Proc | 1971 | https://conductscience.org/library/papers/4941150 | PubMed |
Cited by105
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 349 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,959,165 | Genomics and metabolomics analyses reveal the endophytic fungus Neocucurbitaria sp. VM-36 as a potential source of bioactive metabolites against methicillin-resistant Staphylococcus aureus. | Front Microbiol | 2026 | https://conductscience.org/library/papers/42959165 | PubMed |
| 41,470,047 | SynVerse: a modular framework for building and evaluating deep learning-based drug synergy prediction models. | Brief Bioinform | 2025 | https://conductscience.org/library/papers/41470047 | PubMed |
| 41,086,909 | Synergistic toxicity of PFAS and microplastic mixtures across five human cell lines. | Environ Pollut | 2025 | https://conductscience.org/library/papers/41086909 | PubMed |
| 40,857,031 | Prediction of mixture toxicity of essential oil constituents using nonparametric and parametric models against Musca domestica L. | Pest Manag Sci | 2025 | https://conductscience.org/library/papers/40857031 | PubMed |
| 39,140,776 | Non-small cell lung cancer sensitisation to platinum chemotherapy via new thiazole-triazole hybrids acting as dual T-type CCB/MMP-9 inhibitors. | J Enzyme Inhib Med Chem | 2024 | https://conductscience.org/library/papers/39140776 | PubMed |
| 38,675,443 | State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives. | Pharmaceuticals (Basel) | 2024 | https://conductscience.org/library/papers/38675443 | PubMed |
| 36,541,800 | Enhancing HIV-1 Neutralization by Increasing the Local Concentration of Membrane-Proximal External Region-Directed Broadly Neutralizing Antibodies. | J Virol | 2023 | https://conductscience.org/library/papers/36541800 | PubMed |
| 36,493,860 | Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy. | Exp Neurol | 2023 | https://conductscience.org/library/papers/36493860 | PubMed |
| 35,972,279 | In Vitro Selective Combinatory Effect of Ciprofloxacin with Nitroxoline, Sanguinarine, and Zinc Pyrithione against Diarrhea-Causing and Gut Beneficial Bacteria. | Microbiol Spectr | 2022 | https://conductscience.org/library/papers/35972279 | PubMed |
| 35,849,634 | Sample-efficient identification of high-dimensional antibiotic synergy with a normalized diagonal sampling design. | PLoS Comput Biol | 2022 | https://conductscience.org/library/papers/35849634 | PubMed |
| 35,620,200 | Evaluation of synergism in drug combinations and reference models for future orientations in oncology. | Curr Res Pharmacol Drug Discov | 2022 | https://conductscience.org/library/papers/35620200 | PubMed |
| 35,493,962 | Role of the Synergistic Interactions of Environmental Pollutants in the Development of Cancer. | Geohealth | 2022 | https://conductscience.org/library/papers/35493962 | PubMed |
| 35,327,591 | Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice. | Biomolecules | 2022 | https://conductscience.org/library/papers/35327591 | PubMed |
| 35,054,773 | High-Throughput 3D Tumor Spheroid Array Platform for Evaluating Sensitivity of Proton-Drug Combinations. | Int J Mol Sci | 2022 | https://conductscience.org/library/papers/35054773 | PubMed |
| 34,764,748 | Modulating effects of the synergistic combination of extracts of herbal drugs on cyclophosphamide-induced immunosuppressed mice. | Saudi J Biol Sci | 2021 | https://conductscience.org/library/papers/34764748 | PubMed |
| 34,185,537 | Synergy in Nanomedicine: What It Is Not, and What It Might Be. | Nano Lett | 2021 | https://conductscience.org/library/papers/34185537 | PubMed |
| 34,164,422 | Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review. | Front Nutr | 2021 | https://conductscience.org/library/papers/34164422 | PubMed |
| 32,507,997 | Sub-additive (antagonistic) interaction of lacosamide with lamotrigine and valproate in the maximal electroshock-induced seizure model in mice: an isobolographic analysis. | Pharmacol Rep | 2020 | https://conductscience.org/library/papers/32507997 | PubMed |
| 31,850,215 | Systematic Evaluation of Gastric Tumor Cell Index and Two-Drug Combination Therapy via 3-Dimensional High-Throughput Drug Screening. | Front Oncol | 2019 | https://conductscience.org/library/papers/31850215 | PubMed |
| 31,849,651 | Additive Dose Response Models: Defining Synergy. | Front Pharmacol | 2019 | https://conductscience.org/library/papers/31849651 | PubMed |
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- 2026-11-11
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- 2026-09-18
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- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
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- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
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- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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