Paper · 34627

Adrenergic modulation of pancreatic A, B, and D cells alpha-Adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulation of glucagon secretion in the perfused dog pancreas.

Samols E and 1 other. J Clin Invest, 1979. Cited by 204 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Adrenergic modulation of pancreatic A, B, and D cells alpha-Adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulation of glucagon secretion in the perfused dog pancreas. Papers, record 34627. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/34627

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Adrenergic modulation of pancreatic A, B, and D cells alpha-Adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulation of glucagon secretion in the perfused dog pancreas.; PubMed
Journal: J Clin Invest; PubMed
Year: 1979; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/34627/; PubMed
DOI: https://doi.org/10.1172/jci109294; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC371944/; PubMed
The journal: https://conductscience.org/library/journal-index/7802877; PubMed
Citations, by iCite: 204; iCite
Relative citation ratio, by iCite: 8.5; iCite
Revised in PubMed: 2018-12-17; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Samols E	E
2	Weir GC	G C

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Glucagon	Major topic
Pancreas	Major topic
Receptors, Adrenergic	Major topic
Receptors, Adrenergic, alpha	Major topic
Receptors, Adrenergic, beta	Major topic
Somatostatin	Major topic
Adrenergic alpha-Agonists
Adrenergic alpha-Antagonists
Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Animals
Dogs
Insulin
Insulin Secretion
Male

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References17

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,153,713	The effect of adrenergic blockade on the glucagon responses to starvation and hypoglycemia in man.	J Clin Invest	1974	https://conductscience.org/library/papers/4153713	PubMed
2	4,394,100	Pharmacological characteristics of adrenergic receptors.	Fed Proc	1970	https://conductscience.org/library/papers/4394100	PubMed
3	4,430,716	Glucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas.	J Clin Invest	1974	https://conductscience.org/library/papers/4430716	PubMed
4	4,601,624	Neural control of the endocrine pancreas.	Physiol Rev	1974	https://conductscience.org/library/papers/4601624	PubMed
5	4,727,451	Adrenergic receptors and the secretion of glucagon and insulin from the isolated, perfused canine pancreas.	J Clin Invest	1973	https://conductscience.org/library/papers/4727451	PubMed
6	4,825,234	Adrenergic modulation of pancreatic glucagon secretion in man.	J Clin Invest	1974	https://conductscience.org/library/papers/4825234	PubMed
7	48,838	Growth-hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells.	Lancet	1975	https://conductscience.org/library/papers/48838	PubMed
8	5,232,334	The pharmacological differentiation of adrenergic receptors.	Ann N Y Acad Sci	1967	https://conductscience.org/library/papers/5232334	PubMed
9	5,320,561	Coated charcoal immunoassay of insulin.	J Clin Endocrinol Metab	1965	https://conductscience.org/library/papers/5320561	PubMed
10	5,543,636	Evidence for a feedback inhibition of insulin on insulin secretion in the isolated, perfused canine pancreas.	Diabetes	1971	https://conductscience.org/library/papers/5543636	PubMed

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Cited by40

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 204 citations.

PMID	Title	Journal	Year	In Papers	Source
38,593,829	Urocortin 3 contributes to paracrine inhibition of islet alpha cells in mice.	J Endocrinol	2024	https://conductscience.org/library/papers/38593829	PubMed
38,127,123	GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.	Diabetologia	2024	https://conductscience.org/library/papers/38127123	PubMed
34,460,580	Imaging Meets Cytometry: Analyzing Heterogeneous Functional Microscopic Data from Living Cell Populations.	J Imaging	2021	https://conductscience.org/library/papers/34460580	PubMed
33,589,583	Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors.	Transl Psychiatry	2021	https://conductscience.org/library/papers/33589583	PubMed
30,710,078	Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats.	Nat Commun	2019	https://conductscience.org/library/papers/30710078	PubMed
29,563,152	Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.	Diabetes	2018	https://conductscience.org/library/papers/29563152	PubMed
27,942,826	Autonomic function and control of pancreatic somatostatin.	Diabetologia	1981	https://conductscience.org/library/papers/27942826	PubMed
27,942,817	Interactions between autonomic nerves and endocrine cells of the gastroenteropancreatic system.	Diabetologia	1981	https://conductscience.org/library/papers/27942817	PubMed
25,898,950	Exercise effects on postprandial glucose metabolism in type 1 diabetes: a triple-tracer approach.	Am J Physiol Endocrinol Metab	2015	https://conductscience.org/library/papers/25898950	PubMed
24,947,582	A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1.	Diabetologia	2014	https://conductscience.org/library/papers/24947582	PubMed

1 to 10 of 40

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None in this release.

Drugs0

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None in this release.

Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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