Paper · 358297

Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1alpha on the rat gastric mucosa in vivo and in vitro.

Whittle BJ and 3 others. Prostaglandins, 1978. Cited by 174 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1alpha on the rat gastric mucosa in vivo and in vitro. Papers, record 358297. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/358297

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1alpha on the rat gastric mucosa in vivo and in vitro.; PubMed
Journal: Prostaglandins; PubMed
Year: 1978; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/358297/; PubMed
DOI: https://doi.org/10.1016/0090-6980(78)90038-2; PubMed
The journal: https://conductscience.org/library/journal-index/0320271; PubMed
Citations, by iCite: 174; iCite
Relative citation ratio, by iCite: 7.53; iCite
Revised in PubMed: 2019-08-23; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Whittle BJ	B J
2	Boughton-Smith NK	N K
3	Moncada S	S
4	Vane JR	J R

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Epoprostenol	Major topic
Gastric Juice	Major topic
Gastric Mucosa	Major topic
Prostaglandins	Major topic
Prostaglandins F, Synthetic	Major topic
Animals
Indomethacin
Infusions, Parenteral
Pentagastrin
Prostaglandins E
Rats
Secretory Rate
Stomach Diseases

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

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Cited by23

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 174 citations.

PMID	Title	Journal	Year	In Papers	Source
31,936,877	Study of Melatonin as Preventive Agent of Gastrointestinal Damage Induced by Sodium Diclofenac.	Cells	2020	https://conductscience.org/library/papers/31936877	PubMed
26,516,523	Pharmacogenetics of analgesic drugs.	Br J Pain	2013	https://conductscience.org/library/papers/26516523	PubMed
8,220,892	Thirteenth Gaddum Memorial Lecture. Neuronal and endothelium-derived mediators in the modulation of the gastric microcirculation: integrity in the balance.	Br J Pharmacol	1993	https://conductscience.org/library/papers/8220892	PubMed
7,042,448	Prostacyclin content of gastric and duodenal biopsies.	Gastroenterol Jpn	1982	https://conductscience.org/library/papers/7042448	PubMed
7,040,000	A comparison of the effects of prostacyclin and the 15(S), 15-methyl analogs of PGE2 and PGF2-alpha on gastric parietal and nonparietal secretion.	Dig Dis Sci	1982	https://conductscience.org/library/papers/7040000	PubMed
6,998,689	Comparison of prostacyclin and prostaglandin E2 on gastric secretion, gastrin release, and mucosal blood flow in dogs.	Dig Dis Sci	1980	https://conductscience.org/library/papers/6998689	PubMed
6,796,678	Stimulated gastric prostaglandin output, and the effect of inhibition of prostaglandin synthetase, in the conscious cat.	J Physiol	1981	https://conductscience.org/library/papers/6796678	PubMed
6,581,036	Diflunisal protects human gastric mucosa against damage by indomethacin.	Dig Dis Sci	1983	https://conductscience.org/library/papers/6581036	PubMed
6,368,147	Stimulation of gastric prostaglandin synthesis by refeeding in the rat. Role in protection of gastric mucosa from damage.	Dig Dis Sci	1984	https://conductscience.org/library/papers/6368147	PubMed
6,360,279	Central nervous system effects of arachidonic acid, PGE2, PGF2 alpha, PGD2 and PGI2 on gastric secretion in the rat.	Br J Pharmacol	1983	https://conductscience.org/library/papers/6360279	PubMed

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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