Paper3755366

The depolarizing action of 5-hydroxytryptamine on rabbit vagal afferent and sympathetic neurones in vitro and its selective blockade by ICS 205-930.

Round A and 1 other. Br J Pharmacol, 1986. Cited by 100 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The depolarizing action of 5-hydroxytryptamine on rabbit vagal afferent and sympathetic neurones in vitro and its selective blockade by ICS 205-930. Papers, record 3755366. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3755366

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The depolarizing action of 5-hydroxytryptamine on rabbit vagal afferent and sympathetic neurones in vitro and its selective blockade by ICS 205-930.; PubMed
Journal: Br J Pharmacol; PubMed
Year: 1986; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/3755366/; PubMed
DOI: https://doi.org/10.1111/j.1476-5381.1986.tb10227.x; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC1916829/; PubMed
The journal: https://conductscience.org/library/journal-index/7502536; PubMed
Citations, by iCite: 100; iCite
Relative citation ratio, by iCite: 4.75; iCite
Revised in PubMed: 2019-05-11; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Round A	A
2	Wallis DI	D I

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Indoles	Major topic
Neurons, Afferent	Major topic
Serotonin	Major topic
Sympathetic Nervous System	Major topic
Animals
Dimethylphenylpiperazinium Iodide
Female
Ganglia, Spinal
In Vitro Techniques
Male
Rabbits
Tropisetron

Source PubMed

Show 6 more topicsShow fewer topics

References17

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	240,641	Recording resting and action potentials by the sucrose-gap method.	Comp Biochem Physiol C Comp Pharmacol	1975	https://conductscience.org/library/papers/240641	PubMed
2	13,651,579	Some quantitative uses of drug antagonists.	Br J Pharmacol Chemother	1959	https://conductscience.org/library/papers/13651579	PubMed
3	1,276,530	Mechanism of the indirect sympathomimetic effect of 5-hydroxytrypt-amine on the isolated heart of the rabbit.	Br J Pharmacol	1976	https://conductscience.org/library/papers/1276530	PubMed
4	658,121	Blockade of neuronal tryptamine receptors by metoclopramide.	Eur J Pharmacol	1978	https://conductscience.org/library/papers/658121	PubMed
5	745,689	The action of 5-hydroxytryptamine on single neurones of the rabbit superior cervical ganglion.	Neuropharmacology	1978	https://conductscience.org/library/papers/745689	PubMed
6	492,358	Effects of 5-hydroxytryptamine and related compounds on the sympathetic nerves of the rabbit heart.	Naunyn Schmiedebergs Arch Pharmacol	1979	https://conductscience.org/library/papers/492358	PubMed
7	527,645	Blockade of serotonin receptors on autonomic neurones by (-)-cocaine and some related compounds.	Eur J Pharmacol	1979	https://conductscience.org/library/papers/527645	PubMed
8	6,267,647	Citalopram: a new potent inhibitor of serotonin (5-HT) uptake with central 5-HT-mimetic properties.	Psychopharmacology (Berl)	1981	https://conductscience.org/library/papers/6267647	PubMed
9	7,033,702	Neuronal 5-hydroxytryptamine receptors outside the central nervous system.	Life Sci	1981	https://conductscience.org/library/papers/7033702	PubMed
10	7,063,107	Depolarizing responses recorded from nodose ganglion cells of the rabbit evoked by 5-hydroxytryptamine and other substances.	Neuropharmacology	1982	https://conductscience.org/library/papers/7063107	PubMed
11	7,097,585	5-Hydroxytryptamine receptors of visceral primary afferent neurones on rabbit nodose ganglia.	J Physiol	1982	https://conductscience.org/library/papers/7097585	PubMed
12	7,052,342	Antagonism of 5-hydroxytryptamine receptors by quipazine.	Br J Pharmacol	1980	https://conductscience.org/library/papers/7052342	PubMed
13	6,086,912	Generation of an unusual depolarizing response in rabbit primary afferent neurones in the absence of divalent cations.	J Physiol	1984	https://conductscience.org/library/papers/6086912	PubMed
14	6,527,747	Neuronal 5-HT receptors in the periphery.	Neuropharmacology	1984	https://conductscience.org/library/papers/6527747	PubMed
15	3,990,828	The depolarizing action of 5-hydroxytryptamine on rabbit vagal primary afferent and sympathetic neurones and its selective blockade by MDL 72222.	Naunyn Schmiedebergs Arch Pharmacol	1985	https://conductscience.org/library/papers/3990828	PubMed
16	3,839,291	Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs.	Nature	1985	https://conductscience.org/library/papers/3839291	PubMed
18	1,201,378	Membrane potential changes induced by 5-hydroxytryptamine in the rabbit superior cervical ganglion.	Br J Pharmacol	1975	https://conductscience.org/library/papers/1201378	PubMed

Show 11 more referencesShow fewer references

Cited by23

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 100 citations.

PMID	Title	Journal	Year	In Papers	Source
19,941,848	Pranlukast prevents cysteinyl leukotriene-induced emesis in the least shrew (Cryptotis parva).	Eur J Pharmacol	2010	https://conductscience.org/library/papers/19941848	PubMed
12,077,056	Visceral perception: sensory transduction in visceral afferents and nutrients.	Gut	2002	https://conductscience.org/library/papers/12077056	PubMed
11,139,451	Pharmacological characterization of the 5-HT receptor-mediated contraction in the mouse isolated ileum.	Br J Pharmacol	2000	https://conductscience.org/library/papers/11139451	PubMed
9,596,795	Role of 5-HT3 receptors in activation of abdominal sympathetic C fibre afferents during ischaemia in cats.	J Physiol	1998	https://conductscience.org/library/papers/9596795	PubMed
8,839,677	Biotransformation of the antiemetic 5-HT3 antagonist tropisetron in liver and kidney slices of human, rat and dog with a comparison to in vivo.	Eur J Drug Metab Pharmacokinet	1996	https://conductscience.org/library/papers/8839677	PubMed
8,012,716	5-HT3 receptors do not mediate vagally-induced relaxation or contraction of the isolated stomach of the guinea-pig.	Br J Pharmacol	1994	https://conductscience.org/library/papers/8012716	PubMed
7,694,755	An electrophysiological investigation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture.	Br J Pharmacol	1993	https://conductscience.org/library/papers/7694755	PubMed
7,606,337	Functional dopamine D2 receptors on rat vagal afferent neurones.	Br J Pharmacol	1995	https://conductscience.org/library/papers/7606337	PubMed
3,814,920	Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve.	Br J Pharmacol	1987	https://conductscience.org/library/papers/3814920	PubMed
3,814,917	Influence of 5-hydroxytryptamine uptake on the apparent 5-hydroxytryptamine antagonist potency of metoclopramide in the rat isolated superior cervical ganglion.	Br J Pharmacol	1987	https://conductscience.org/library/papers/3814917	PubMed
3,607,365	Activation of 5-HT3 receptor subtypes causes rapid excitation of rabbit parasympathetic neurones.	Br J Pharmacol	1987	https://conductscience.org/library/papers/3607365	PubMed
3,412,489	Characterisation of 5-HT3 recognition sites in membranes of NG 108-15 neuroblastoma-glioma cells with [3H]ICS 205-930.	Naunyn Schmiedebergs Arch Pharmacol	1988	https://conductscience.org/library/papers/3412489	PubMed
3,349,227	A comparison of fast and slow depolarizations evoked by 5-HT in guinea-pig coeliac ganglion cells in vitro.	Br J Pharmacol	1988	https://conductscience.org/library/papers/3349227	PubMed
3,244,397	The depolarizing action of 5-hydroxytryptamine on rabbit isolated preganglionic cervical sympathetic nerves.	Naunyn Schmiedebergs Arch Pharmacol	1988	https://conductscience.org/library/papers/3244397	PubMed
2,969,267	Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors.	Br J Pharmacol	1988	https://conductscience.org/library/papers/2969267	PubMed
2,720,311	The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques.	Br J Pharmacol	1989	https://conductscience.org/library/papers/2720311	PubMed
2,586,633	[3H]ICS 205-930 labels 5-HT3 recognition sites in membranes of cat and rabbit vagus nerve and superior cervical ganglion.	Naunyn Schmiedebergs Arch Pharmacol	1989	https://conductscience.org/library/papers/2586633	PubMed
2,402,301	[3H] GR67330, a very high affinity ligand for 5-HT3 receptors.	Naunyn Schmiedebergs Arch Pharmacol	1990	https://conductscience.org/library/papers/2402301	PubMed
2,076,487	The effects of 5-HT on articular sensory receptors in normal and arthritic rats.	Br J Pharmacol	1990	https://conductscience.org/library/papers/2076487	PubMed
1,855,111	5-Hydroxytryptamine-induced bronchoconstriction in the guinea-pig: effect of 5-HT2 receptor activation on acetylcholine release.	Br J Pharmacol	1991	https://conductscience.org/library/papers/1855111	PubMed

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
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