Paper · 3882995

A deletion mutation in the 5' part of the pol gene of Moloney murine leukemia virus blocks proteolytic processing of the gag and pol polyproteins.

Crawford S and 1 other. J Virol, 1985. Cited by 240 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A deletion mutation in the 5' part of the pol gene of Moloney murine leukemia virus blocks proteolytic processing of the gag and pol polyproteins. Papers, record 3882995. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3882995

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A deletion mutation in the 5' part of the pol gene of Moloney murine leukemia virus blocks proteolytic processing of the gag and pol polyproteins.; PubMed
Journal: J Virol; PubMed
Year: 1985; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/3882995/; PubMed
DOI: https://doi.org/10.1128/jvi.53.3.899-907.1985; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC254725/; PubMed
The journal: https://conductscience.org/library/journal-index/0113724; PubMed
Citations, by iCite: 240; iCite
Relative citation ratio, by iCite: 5.44; iCite
Revised in PubMed: 2025-07-03; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Crawford S	S
2	Goff SP	S P

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Chromosome Deletion	Major topic
Genes, Viral	Major topic
Moloney murine leukemia virus	Major topic
Mutation	Major topic
Peptide Hydrolases	Major topic
Viral Envelope Proteins	Major topic
Viral Proteins	Major topic
Animals
Cell Line
Cell Transformation, Viral
DNA, Viral
Gene Products, gag
Mice
Transcription, Genetic
Viral Fusion Proteins

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
CA 30488	NCI NIH HHS	United States	R01CA030488	PubMed and NIH	NIH RePORTER
			R37CA030488	NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References57

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,291,934	Selective extraction of polyoma DNA from infected mouse cell cultures.	J Mol Biol	1967	https://conductscience.org/library/papers/4291934	PubMed
2	72,613	Properties of a P70 proteolytic factor of murine leukemia viruses.	Cell	1977	https://conductscience.org/library/papers/72613	PubMed
3	5,432,063	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	Nature	1970	https://conductscience.org/library/papers/5432063	PubMed
4	4,922,220	Calcium-dependent bacteriophage DNA infection.	J Mol Biol	1970	https://conductscience.org/library/papers/4922220	PubMed
5	4,099,080	Plaque assay techniques for murine leukemia viruses.	Virology	1970	https://conductscience.org/library/papers/4099080	PubMed
6	202,399	Translation of MuLV and MSV RNAs in nuclease-treated reticulocyte extracts: enhancement of the gag-pol polypeptide with yeast suppressor tRNA.	Cell	1978	https://conductscience.org/library/papers/202399	PubMed
7	75,071	Cell-free synthesis of a precursor polyprotein containing both gag and pol gene products by Rauscher murine leukemia virus 35S RNA.	Cell	1978	https://conductscience.org/library/papers/75071	PubMed
8	625,083	Impaired processing of precursor polypeptides of temperature-sensitive mutants of Rauscher murine leukemia virus.	J Virol	1978	https://conductscience.org/library/papers/625083	PubMed
9	206,897	Amino- and carboxyl-terminal amino acid sequences of proteins coded by gag gene of murine leukemia virus.	Proc Natl Acad Sci U S A	1978	https://conductscience.org/library/papers/206897	PubMed
10	77,678	The biosynthesis of oncovirus proteins.	Biochim Biophys Acta	1978	https://conductscience.org/library/papers/77678	PubMed

1 to 10 of 57

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Cited by114

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 240 citations.

PMID	Title	Journal	Year	In Papers	Source
41,453,210	Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication.	FEMS Microbiol Rev	2026	https://conductscience.org/library/papers/41453210	PubMed
34,287,037	Structural Determinants of Virion Assembly and Release in the C Terminus of the Mason-Pfizer Monkey Virus Capsid Protein.	J Virol	2021	https://conductscience.org/library/papers/34287037	PubMed
30,414,407	HIV-1 Protease Uses Bi-Specific S2/S2' Subsites to Optimize Cleavage of Two Classes of Target Sites.	J Mol Biol	2018	https://conductscience.org/library/papers/30414407	PubMed
27,611,878	Structural biology in antiviral drug discovery.	Curr Opin Pharmacol	2016	https://conductscience.org/library/papers/27611878	PubMed
25,525,240	RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses.	Science	2014	https://conductscience.org/library/papers/25525240	PubMed
25,190,459	Gammaretrovirus mRNA expression is mediated by a novel, bipartite post-transcriptional regulatory element.	Nucleic Acids Res	2014	https://conductscience.org/library/papers/25190459	PubMed
22,718,819	Large ribosomal protein 4 increases efficiency of viral recoding sequences.	J Virol	2012	https://conductscience.org/library/papers/22718819	PubMed
21,550,256	Diverse interactions of retroviral Gag proteins with RNAs.	Trends Biochem Sci	2011	https://conductscience.org/library/papers/21550256	PubMed
21,149,734	Profile of Stephen P. Goff. Interview by Greg Williams.	Proc Natl Acad Sci U S A	2011	https://conductscience.org/library/papers/21149734	PubMed
21,045,546	Nucleic acid chaperone activity of retroviral Gag proteins.	RNA Biol	2010	https://conductscience.org/library/papers/21045546	PubMed

1 to 10 of 114

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession
GENBANK	M10413

Source GENBANK

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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