Paper · 39147758

Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds.

Malone K and 5 others. Cell Death Dis, 2024. Cited by 14 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds. Papers, record 39147758. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39147758

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds.; PubMed
Journal: Cell Death Dis; PubMed
Year: 2024; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/39147758/; PubMed
DOI: https://doi.org/10.1038/s41419-024-06971-5; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC11327263/; PubMed
The journal: https://conductscience.org/library/journal-index/101524092; PubMed
Citations, by iCite: 14; iCite
Relative citation ratio, by iCite: 1.92, provisional; iCite
Revised in PubMed: 2026-09-14; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Malone K	Kyle	https://orcid.org/0000-0002-9933-7302
2	Dugas M	Melanie
3	Earl N	Nathalie
4	Alain T	Tommy	https://orcid.org/0000-0002-0396-9138
5	LaCasse EC	Eric C
6	Beug ST	Shawn T	https://orcid.org/0000-0002-9991-3306

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Glioblastoma	Major topic
Tumor Microenvironment	Major topic
Astrocytes	Major topic
Animals
Humans
Cell Line, Tumor
Mice
Brain Neoplasms
Tumor Necrosis Factor-alpha
Microglia
Macrophages
Inflammation
Mitochondrial Proteins
Apoptosis Regulatory Proteins
Intracellular Signaling Peptides and Proteins
Mice, Inbred C57BL

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References79

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	23,248,260	Balance between NF-κB p100 and p52 regulates T cell costimulation dependence.	J Immunol	2013	https://conductscience.org/library/papers/23248260	PubMed
2	30,971,917	The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma.	Front Pharmacol	2019	https://conductscience.org/library/papers/30971917	PubMed
3	26,205,340	Evolving synergistic combinations of targeted immunotherapies to combat cancer.	Nat Rev Cancer	2015	https://conductscience.org/library/papers/26205340	PubMed
4	25,860,605	Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.	Cell	2015	https://conductscience.org/library/papers/25860605	PubMed
5	18,931,692	IAP-targeted therapies for cancer.	Oncogene	2008	https://conductscience.org/library/papers/18931692	PubMed
6	28,198,370	Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma.	Nat Commun	2017	https://conductscience.org/library/papers/28198370	PubMed
7	26,027,431	Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.	N Engl J Med	2015	https://conductscience.org/library/papers/26027431	PubMed
8	35,769,925	Establishing a multiplex imaging panel to study T cell development in the thymus in mouse.	STAR Protoc	2022	https://conductscience.org/library/papers/35769925	PubMed
9	29,165,393	The Role of Hypoxia in Glioblastoma Invasion.	Cells	2017	https://conductscience.org/library/papers/29165393	PubMed
10	35,008,722	A Novel Role of BIRC3 in Stemness Reprogramming of Glioblastoma.	Int J Mol Sci	2021	https://conductscience.org/library/papers/35008722	PubMed

1 to 10 of 79

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Cited by11

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 14 citations.

PMID	Title	Journal	Year	In Papers	Source
42,491,242	Reconstructing the glioblastoma microenvironment in heterotypic 3D spheroids: a multicellular model to study tumor-stromal crosstalk.	Front Bioeng Biotechnol	2026	https://conductscience.org/library/papers/42491242	PubMed
42,170,360	Targeting immune microenvironment-mediated mesenchymal transition in glioblastoma: Molecular mechanisms and translational strategies.	Neurooncol Adv	2026	https://conductscience.org/library/papers/42170360	PubMed
42,026,142	Astrocyte-driven immunosuppression in the brain tumor microenvironment.	Nat Immunol	2026	https://conductscience.org/library/papers/42026142	PubMed
41,909,736	Targeting immunosuppressive network in glioblastoma: Emerging strategies to overcome immunodeficiency and enhance therapeutic efficacy.	Acta Pharm Sin B	2026	https://conductscience.org/library/papers/41909736	PubMed
41,762,656	Lipocalin 2 orchestrates resistance to ferroptosis via AXL.	Cell Rep	2026	https://conductscience.org/library/papers/41762656	PubMed
41,710,466	Neuronal injury and hepatotoxicity: astrocytes and stellate cells convergence and their role in tissue repair.	Front Neurosci	2025	https://conductscience.org/library/papers/41710466	PubMed
41,696,491	Enhanced glioblastoma immunotherapy via SMAC mimetic dose escalation and TGFβ blockade.	Neurooncol Adv	2026	https://conductscience.org/library/papers/41696491	PubMed
41,612,972	Muribaculum intestinale negatively impacts glioma growth in mice through the toll-like receptor 2.	Gut Microbes	2026	https://conductscience.org/library/papers/41612972	PubMed
41,463,173	Natural Anti-Inflammatory Agents in the Chemoprevention of Gliomas: Targeting Neuroinflammation and the Tumor Microenvironment.	Cancers (Basel)	2025	https://conductscience.org/library/papers/41463173	PubMed
40,149,331	Effects of Induced Pluripotent Stem Cell-Derived Astrocytes on Cisplatin Sensitivity in Pediatric Brain Cancer Cells.	Cancers (Basel)	2025	https://conductscience.org/library/papers/40149331	PubMed

1 to 10 of 11

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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