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Paper39307306

Integrated multi-omics unveil the impact of H-phosphinic analogs of glutamate and α-ketoglutarate on Escherichia coli metabolism.

Giovannercole F and 5 others. J Biol Chem, 2024. Cited by 6 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Integrated multi-omics unveil the impact of H-phosphinic analogs of glutamate and α-ketoglutarate on Escherichia coli metabolism. Papers, record 39307306. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39307306

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Integrated multi-omics unveil the impact of H-phosphinic analogs of glutamate and α-ketoglutarate on Escherichia coli metabolism.
PubMed
Journal
J Biol Chem
PubMed
Year
2024
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
6
iCite
Relative citation ratio, by iCite
1.38, provisional
iCite
Revised in PubMed
2026-02-21
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Giovannercole FFabio
2Gafeira Gonçalves LLuís
3Armengaud JJean
4Varela Coelho AAna
5Khomutov AAlex
6De Biase DDaniela

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Escherichia coliMajor topic
Ketoglutaric AcidsMajor topic
Escherichia coli Proteins
Glutamic Acid
Anti-Bacterial Agents
Phosphinic Acids
Metabolomics
Aminobutyrates
Glutamate Decarboxylase
Proteomics
Multiomics

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
OT2 OD030544NIH HHSUnited StatesOT2OD030544PubMedNIH RePORTER
U2C DK119886NIDDK NIH HHSUnited StatesU2CDK119886PubMedNIH RePORTER

References78

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,329,256The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition.Biochemistry2001https://conductscience.org/library/papers/11329256PubMed
237,985,709Exploitation of microbial activities at low pH to enhance planetary health.FEMS Microbiol Rev2024https://conductscience.org/library/papers/37985709PubMed
318,808,381
GadX/GadW-dependent regulation of the Escherichia coli acid fitness island: transcriptional control at the gadY-gadW divergent promoters and identification of four novel 42 bp GadX/GadW-specific binding sites.
Mol Microbiol2008https://conductscience.org/library/papers/18808381PubMed
423,034,226Discovery and biosynthesis of phosphonate and phosphinate natural products.Methods Enzymol2012https://conductscience.org/library/papers/23034226PubMed
536,419,429Subinhibitory antibiotic concentrations promote the horizontal transfer of plasmid-borne resistance genes from Klebsiellae pneumoniae to Escherichia coli.Front Microbiol2022https://conductscience.org/library/papers/36419429PubMed
611,472,937The phosphinomethylmalate isomerase gene pmi, encoding an aconitase-like enzyme, is involved in the synthesis of phosphinothricin tripeptide in Streptomyces viridochromogenes.Appl Environ Microbiol2001https://conductscience.org/library/papers/11472937PubMed
78,576,037Galactofuranose biosynthesis in Escherichia coli K-12: identification and cloning of UDP-galactopyranose mutase.J Bacteriol1996https://conductscience.org/library/papers/8576037PubMed
81,556,144Escherichia coli alpha-ketoglutarate permease is a constitutively expressed proton symporter.J Biol Chem1992https://conductscience.org/library/papers/1556144PubMed
92,751,713[Enzyme reamination of phosphororganic analogs of aspartate and glutamate].Bioorg Khim1989https://conductscience.org/library/papers/2751713PubMed
1024,296,575Nitrogen assimilation in Escherichia coli: putting molecular data into a systems perspective.Microbiol Mol Biol Rev2013https://conductscience.org/library/papers/24296575PubMed
1116,251,301Phosphinothricin tripeptide synthetases in Streptomyces viridochromogenes Tü494.Antimicrob Agents Chemother2005https://conductscience.org/library/papers/16251301PubMed
124,196,588Transport of vitamin B 12 in Escherichia coli. Location and properties of the initial B 12 -binding site.J Biol Chem1973https://conductscience.org/library/papers/4196588PubMed
1331,555,227Evaluation of Sample Preparation Methods for Fast Proteotyping of Microorganisms by Tandem Mass Spectrometry.Front Microbiol2019https://conductscience.org/library/papers/31555227PubMed
1426,324,907Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes.Proc Natl Acad Sci U S A2015https://conductscience.org/library/papers/26324907PubMed
1534,717,010PANTHER: Making genome-scale phylogenetics accessible to all.Protein Sci2022https://conductscience.org/library/papers/34717010PubMed
163,730,360
Time-dependent inhibition of Bacillus stearothermophilus alanine racemase by (1-aminoethyl)phosphonate isomers by isomerization to noncovalent slowly dissociating enzyme-(1-aminoethyl)phosphonate complexes.
Biochemistry1986https://conductscience.org/library/papers/3730360PubMed
171,367,200Genetic analysis of the phosphinothricin-tripeptide biosynthetic pathway of Streptomyces viridochromogenes Tü494.Appl Microbiol Biotechnol1991https://conductscience.org/library/papers/1367200PubMed
188,501,045The Escherichia coli K-12 "wild types" W3110 and MG1655 have an rph frameshift mutation that leads to pyrimidine starvation due to low pyrE expression levels.J Bacteriol1993https://conductscience.org/library/papers/8501045PubMed
1919,561,621Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli.Nat Chem Biol2009https://conductscience.org/library/papers/19561621PubMed
2026,024,289Inhibitors of alanine racemase enzyme: a review.J Enzyme Inhib Med Chem2016https://conductscience.org/library/papers/26024289PubMed

See all 78 references

Cited by4

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 6 citations.

PMIDTitleJournalYearIn PapersSource
42,123,362Integrated Transcriptomics and Metabolomic Profiling Suggests That Thymol Adaptation Induces Multi-Layered Envelope and Metabolic Perturbations That Sensitize Pseudomonas psychrophila to Antibiotics.Int J Mol Sci2026https://conductscience.org/library/papers/42123362PubMed
42,005,840H-phosphinic analogs of natural amino acids: a novel and efficient treatment for preventing biodeterioration of treasured painted artworks.Front Microbiol2026https://conductscience.org/library/papers/42005840PubMed
40,943,510Phospho-Switch: Regulation of the Activity of SAM-Dependent Methyltransferases Using H-Phosphinic SAM Analogue.Int J Mol Sci2025https://conductscience.org/library/papers/40943510PubMed
39,766,281Enzymatic Synthesis of Biologically Active H-Phosphinic Analogue of α-Ketoglutarate.Biomolecules2024https://conductscience.org/library/papers/39766281PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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