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Paper · 3932041

Chemistry and synthetic development of misoprostol.

Collins PW and 2 others. Dig Dis Sci, 1985. Cited by 46 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Chemistry and synthetic development of misoprostol. Papers, record 3932041. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3932041

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Chemistry and synthetic development of misoprostol.
PubMed
Journal
Dig Dis Sci
PubMed
Year
1985
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
46
iCite
Relative citation ratio, by iCite
2.4
iCite
Revised in PubMed
2019-07-21
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Collins PWP W
2Pappo RR
3Dajani EZE Z

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AlprostadilMajor topic
Animals
Anti-Ulcer Agents
Chemical Phenomena
Chemistry
Diarrhea
Drug Stability
Gastric Acid
Misoprostol
Prostaglandins E
Structure-Activity Relationship

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References5

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,215,536Influence of the position of the side chain hydroxy group on the gastric antisecretory and antiulcer actions of E1 prostaglandin analogs.Prostaglandins1975https://conductscience.org/library/papers/1215536PubMed
27,000,997Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congenital heart disease.J Pediatr1980https://conductscience.org/library/papers/7000997PubMed
3797,257SC-29333: a potent inhibitor of canin gastric secretion.Am J Dig Dis1976https://conductscience.org/library/papers/797257PubMed
46,854,580Synthesis and gastric antisecretory properties of 4,5-unsaturated derivatives of 15-deoxy-16-hydroxy-16-methylprostaglandin E1.J Med Chem1983https://conductscience.org/library/papers/6854580PubMed
5926,115Synthesis and gastric antisecretory properties of 15-deoxy-16-hydroxyprostaglandin E analogues.J Med Chem1977https://conductscience.org/library/papers/926115PubMed

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 46 citations.

PMIDTitleJournalYearIn PapersSource
32,877,459Stability of misoprostol tablets collected in Malawi and Rwanda: Importance of intact primary packaging.PLoS One2020https://conductscience.org/library/papers/32877459PubMed
32,223,759Quality, availability and storage conditions of oxytocin and misoprostol in Malawi.BMC Pregnancy Childbirth2020https://conductscience.org/library/papers/32223759PubMed
25,502,819Instability of misoprostol tablets stored outside the blister: a potential serious concern for clinical outcome in medical abortion.PLoS One2014https://conductscience.org/library/papers/25502819PubMed
16,455,695Oral misoprostol for induction of labour at term: randomised controlled trial.BMJ2006https://conductscience.org/library/papers/16455695PubMed
14,981,379A randomized trial of saline solution-moistened misoprostol versus dry misoprostol for first-trimester pregnancy failure.Am J Obstet Gynecol2004https://conductscience.org/library/papers/14981379PubMed
8,448,599In vitro characterization of prostanoid receptors on human myometrium at term pregnancy.Br J Pharmacol1993https://conductscience.org/library/papers/8448599PubMed
3,139,378Inhibitory effect of misoprostol on gastric acid secretion in vitro. Qualitative differences from natural prostaglandins.Dig Dis Sci1988https://conductscience.org/library/papers/3139378PubMed
3,134,971The action of prostanoid receptor agonists and antagonists on smooth muscle and platelets.Br J Pharmacol1988https://conductscience.org/library/papers/3134971PubMed
3,040,357Effect of misoprostol on histamine-stimulated acid secretion and cyclic AMP formation in isolated canine parietal cells.Dig Dis Sci1987https://conductscience.org/library/papers/3040357PubMed
1,285,399In vitro characterization of prostanoid EP-receptors in the non-pregnant human myometrium.Br J Pharmacol1991https://conductscience.org/library/papers/1285399PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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