Paper · 39480263

Axon initial segment structure and function in health and disease.

Jenkins PM and 1 other. Physiol Rev, 2025. Cited by 34 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Axon initial segment structure and function in health and disease. Papers, record 39480263. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39480263

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Axon initial segment structure and function in health and disease.; PubMed
Journal: Physiol Rev; PubMed
Year: 2025; PubMed
Publication types: Journal Article, Review, Research Support, N.I.H., Extramural; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/39480263/; PubMed
DOI: https://doi.org/10.1152/physrev.00030.2024; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12239863/; PubMed
The journal: https://conductscience.org/library/journal-index/0231714; PubMed
Citations, by iCite: 34; iCite
Relative citation ratio, by iCite: 9.6, provisional; iCite
Revised in PubMed: 2026-06-02; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Jenkins PM	Paul M		https://orcid.org/0000-0002-4207-5823
2	Bender KJ	Kevin J		https://orcid.org/0000-0001-7084-1532

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Axon Initial Segment	Major topic
Axons	Major topic
Neurons	Major topic
Humans
Animals
Action Potentials
Synapses

Source PubMed

Grants9

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
899599	Simons Foundation Autism Research Initiative (SFARI)			PubMed	PubMed
4551	Simons Foundation Autism Research Initiative (SFARI)			PubMed	PubMed
R01 MH126960	NIMH NIH HHS	United States	R01MH126960	PubMed and NIH	NIH RePORTER
R01 MH136475	NIMH NIH HHS	United States	R01MH136475	PubMed	NIH RePORTER
R01MH125978	HHS \| NIH \| National Institute of Mental Health (NIMH)		R01MH125978	PubMed and NIH	NIH RePORTER
Million Dollar Bike Ride award	FamilieSCN2A Foundation			PubMed	PubMed
R01MH126960	HHS \| NIH \| National Institute of Mental Health (NIMH)		R01MH126960	PubMed and NIH	NIH RePORTER
R01 MH125978	NIMH NIH HHS	United States	R01MH125978	PubMed and NIH	NIH RePORTER
Hodgkin Huxley Research Award	FamilieSCN2A Foundation			PubMed	PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References351

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	17,314,237	Action potential initiation and propagation in CA3 pyramidal axons.	J Neurophysiol	2007	https://conductscience.org/library/papers/17314237	PubMed
2	25,294,986	Molecular identity of axonal sodium channels in human cortical pyramidal cells.	Front Cell Neurosci	2014	https://conductscience.org/library/papers/25294986	PubMed
3	22,063,631	Control of firing patterns through modulation of axon initial segment T-type calcium channels.	J Physiol	2012	https://conductscience.org/library/papers/22063631	PubMed
4	7,615,634	Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain.	J Cell Biol	1995	https://conductscience.org/library/papers/7615634	PubMed
5	28,184,187	Ankyrin G Membrane Partners Drive the Establishment and Maintenance of the Axon Initial Segment.	Front Cell Neurosci	2017	https://conductscience.org/library/papers/28184187	PubMed
6	32,845,893	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	PLoS One	2020	https://conductscience.org/library/papers/32845893	PubMed
7	29,526,554	Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons.	Neuron	2018	https://conductscience.org/library/papers/29526554	PubMed
8	16,625,198	Unique features of action potential initiation in cortical neurons.	Nature	2006	https://conductscience.org/library/papers/16625198	PubMed
9	23,942,886	Plasticity at axon initial segment of hippocampal CA3 neurons in rat after status epilepticus induced by lithium-pilocarpine.	Acta Neurochir (Wien)	2013	https://conductscience.org/library/papers/23942886	PubMed
10	22,764,252	Lack of molecular-anatomical evidence for GABAergic influence on axon initial segment of cerebellar Purkinje cells by the pinceau formation.	J Neurosci	2012	https://conductscience.org/library/papers/22764252	PubMed

1 to 10 of 351

See all 351 references

Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 34 citations.

PMID	Title	Journal	Year	In Papers	Source
42,631,048	Intrinsic electrical diversity of PV+ retinal ganglion cells.	iScience	2026	https://conductscience.org/library/papers/42631048	PubMed
42,460,054	Volume electron microscopy in axon regeneration research: insights into mitochondria, endoplasmic reticulum, and membrane contacts.	Front Neural Circuits	2026	https://conductscience.org/library/papers/42460054	PubMed
42,382,984	Scn2a, encoding Na V 1.2 channel, contributes to tonotopic maturation of spike kinetics in developing mouse MNTB.	Front Cell Neurosci	2026	https://conductscience.org/library/papers/42382984	PubMed
42,344,806	Functional implications of atypical action potential generation in the (patho)physiological brain: from developmental program to glioma.	Front Neural Circuits	2026	https://conductscience.org/library/papers/42344806	PubMed
42,257,687	Compensatory rearrangement of parvalbumin interneuron voltage-gated sodium channel subunits in a mouse model of Dravet syndrome.	Epilepsia	2026	https://conductscience.org/library/papers/42257687	PubMed
42,155,598	Mechanisms of transcranial magnetic brain stimulation.	Physiol Rev	2026	https://conductscience.org/library/papers/42155598	PubMed
42,052,621	Purkinje cell-specific loss of Neurofascin and Ankyrin G causes disruption of axon initial segments, neurodegeneration, and cerebellar ataxia.	Front Cell Neurosci	2026	https://conductscience.org/library/papers/42052621	PubMed
41,948,734	Salidroside derivative SHPL-49 enhances synaptic remodeling in BCCAO rats via the CDK5/p35/p25 signaling pathway.	Front Pharmacol	2026	https://conductscience.org/library/papers/41948734	PubMed
41,877,246	Axonopathy: mechanisms and potential therapeutic targets for neurodegenerative diseases.	Transl Neurodegener	2026	https://conductscience.org/library/papers/41877246	PubMed
41,806,299	Robust activity-dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation.	J Physiol	2026	https://conductscience.org/library/papers/41806299	PubMed

1 to 10 of 27

See all 27 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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