Paper · 39757641

Protein Misfolding and Aggregation of Pathological IgG Light Chains in Oncohematological Dyscrasias: From Molecular Pathways to Clinical Implications.

Guman T and 3 others. Curr Protein Pept Sci, 2025. Cited by 1 paper, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Protein Misfolding and Aggregation of Pathological IgG Light Chains in Oncohematological Dyscrasias: From Molecular Pathways to Clinical Implications. Papers, record 39757641. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39757641

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Protein Misfolding and Aggregation of Pathological IgG Light Chains in Oncohematological Dyscrasias: From Molecular Pathways to Clinical Implications.; PubMed
Journal: Curr Protein Pept Sci; PubMed
Year: 2025; PubMed
Publication types: Journal Article, Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/39757641/; PubMed
DOI: https://doi.org/10.2174/0113892037336731241029075530; PubMed
The journal: https://conductscience.org/library/journal-index/100960529; PubMed
Citations, by iCite: 1; iCite
Revised in PubMed: 2026-01-28; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Guman T	Tomas
2	Sykora J	Jan
3	Demcakova V	Veronika
4	Zoldak G	Gabriel	https://orcid.org/0000-0002-5271-8837

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Protein Folding	Major topic
Immunoglobulin Light Chains	Major topic
Paraproteinemias	Major topic
Immunoglobulin G	Major topic
Protein Aggregation, Pathological	Major topic
Humans
Animals
B-Lymphocytes

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
APVV-18-0285, APVV-23-0212	APVV			PubMed
VEGA 1/0024/22	VEGA			PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References59

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	12,358,904	Tumoral non-amyloidotic monoclonal immunoglobulin light chain deposits ('aggregoma'): presenting feature of B-cell dyscrasia in three cases with immunohistochemical and biochemical analyses.	Br J Haematol	2002	https://conductscience.org/library/papers/12358904	PubMed
2	9,048,542	Refined structure of an intact IgG2a monoclonal antibody.	Biochemistry	1997	https://conductscience.org/library/papers/9048542	PubMed
3	30,971,495	Stabilization of amyloidogenic immunoglobulin light chains by small molecules.	Proc Natl Acad Sci U S A	2019	https://conductscience.org/library/papers/30971495	PubMed
4	33,030,218	A kinetic coupling between protein unfolding and aggregation controls time-dependent solubility of the human myeloma antibody light chain.	Protein Sci	2020	https://conductscience.org/library/papers/33030218	PubMed
5	36,401,959	Aggregation mechanism and branched 3D morphologies of pathological human light chain proteins under reducing conditions.	Colloids Surf B Biointerfaces	2023	https://conductscience.org/library/papers/36401959	PubMed
6	11,266,462	Hsp70 and antifibrillogenic peptides promote degradation and inhibit intracellular aggregation of amyloidogenic light chains.	J Cell Biol	2001	https://conductscience.org/library/papers/11266462	PubMed
7	7,838,842	IgG heavy-chain deposition disease.	Mod Pathol	1994	https://conductscience.org/library/papers/7838842	PubMed
8	8,191,615	Immunoglobulin light chains and the kidney: an overview.	Ultrastruct Pathol	1994	https://conductscience.org/library/papers/8191615	PubMed
9	6,156,005	Structural mutations in a mouse immunoglobulin light chain resulting in failure to be secreted.	Cell	1980	https://conductscience.org/library/papers/6156005	PubMed
10	115,698	Mutations affecting immunoglobulin light chain secretion by myeloma cells. I. Functional analysis by cell fusion.	Eur J Immunol	1979	https://conductscience.org/library/papers/115698	PubMed

1 to 10 of 59

See all 59 references

Cited by1

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1 citation.

PMID	Title	Journal	Year	In Papers
40,708,522	Protein Folding, Aggregation, and Liquid-Liquid Phase Separation.	Curr Protein Pept Sci	2025	https://conductscience.org/library/papers/40708522

Source PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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