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Paper · 39833191

Hedgehog signaling directs cell differentiation and plays a critical role in tendon enthesis healing.

Fang F and 3 others. NPJ Regen Med, 2025. Cited by 4 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Hedgehog signaling directs cell differentiation and plays a critical role in tendon enthesis healing. Papers, record 39833191. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39833191

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Hedgehog signaling directs cell differentiation and plays a critical role in tendon enthesis healing.
PubMed
Journal
NPJ Regen Med
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
4
iCite
Revised in PubMed
2026-03-06
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Fang FFei
2Casserly MMatthew
3Robbins JJulia
4Thomopoulos SStavroshttps://orcid.org/0000-0003-1531-4849

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 AR055580NIAMS NIH HHSUnited StatesR01AR055580PubMedNIH RePORTER
R01 AR080717NIAMS NIH HHSUnited StatesR01AR080717PubMed and NIHNIH RePORTER
R01 AR082797NIAMS NIH HHSUnited StatesR01AR082797PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
130,063,598Expression of Signaling Molecules Involved in Embryonic Development of the Insertion Site Is Inadequate for Reformation of the Native Enthesis: Evaluation in a Novel Murine ACL Reconstruction Model.J Bone Joint Surg Am2018https://conductscience.org/library/papers/30063598PubMed
232,853,181Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification.J Clin Invest2020https://conductscience.org/library/papers/32853181PubMed
329,230,039Gli1 identifies osteogenic progenitors for bone formation and fracture repair.Nat Commun2017https://conductscience.org/library/papers/29230039PubMed
427,887,870Involvement of Indian hedgehog signaling in mesenchymal stem cell-augmented rotator cuff tendon repair in an athymic rat model.J Shoulder Elbow Surg2017https://conductscience.org/library/papers/27887870PubMed
525,465,115Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis.Cell Stem Cell2015https://conductscience.org/library/papers/25465115PubMed
621,185,956Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading.Bone2011https://conductscience.org/library/papers/21185956PubMed
724,677,726Tendon-to-bone attachment: from development to maturity.Birth Defects Res C Embryo Today2014https://conductscience.org/library/papers/24677726PubMed
826,447,744Indian hedgehog signaling and the role of graft tension in tendon-to-bone healing: Evaluation in a rat ACL reconstruction model.J Orthop Res2016https://conductscience.org/library/papers/26447744PubMed
937,897,335Hedgehog Activation for Enhanced Rotator Cuff Tendon-to-Bone Healing.Am J Sports Med2023https://conductscience.org/library/papers/37897335PubMed
1025,516,975Enthesis fibrocartilage cells originate from a population of Hedgehog-responsive cells modulated by the loading environment.Development2015https://conductscience.org/library/papers/25516975PubMed

1 to 10 of 37

See all 37 references

Cited by4

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 4 citations.

PMIDTitleJournalYearIn PapersSource
42,437,285Tendon stem/progenitor cells in heterotopic ossification: functional regulation, molecular mechanisms and targeted therapeutic strategies.J Orthop Translat2026https://conductscience.org/library/papers/42437285PubMed
41,913,328Localized Delivery of a Small Molecule Hedgehog Agonist via Poly(ε-caprolactone) Scaffolds Enhances Tendon-to-Bone Integration.J Orthop Res2026https://conductscience.org/library/papers/41913328PubMed
41,234,689Single-cell sequencing reveals cellular heterogeneity and molecular mechanisms in tendon and enthesis injury repair.Front Physiol2025https://conductscience.org/library/papers/41234689PubMed
40,662,251Biomimetic Scaffolds with Dual Gradients of Biological Effectors for Tendon-to-Bone Repair.Adv Healthc Mater2025https://conductscience.org/library/papers/40662251PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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