Paper · 40402249

Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation.

Zhang Y and 16 others. Proc Natl Acad Sci U S A, 2025. Cited by 17 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation. Papers, record 40402249. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40402249

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 2025; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/40402249/; PubMed
DOI: https://doi.org/10.1073/pnas.2423077122; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12130859/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 17; iCite
Relative citation ratio, by iCite: 3.9, provisional; iCite
Revised in PubMed: 2025-11-23; PubMed

Authors17

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Zhang Y	Yuyuan
2	Zuo A	Anning
3	Ba Y	Yuhao
4	Liu S	Shutong
5	Chen J	Jingqi
6	Yang S	Shuaixi
7	Weng S	Siyuan
8	Chen Y	Yukang
9	Xu H	Hui
10	Luo P	Peng

1 to 10 of 17Source PubMed

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Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Colorectal Neoplasms	Major topic
Liver Neoplasms	Major topic
Cancer-Associated Fibroblasts	Major topic
Neuropilin-2	Major topic
Semaphorins	Major topic
Humans
Animals
Mice
Cell Line, Tumor
MAP Kinase Signaling System
Cell Proliferation
Male

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	34,992,217	Single-cell RNA-seq recognized the initiator of epithelial ovarian cancer recurrence.	Oncogene	2022	https://conductscience.org/library/papers/34992217	PubMed
2	26,457,759	The consensus molecular subtypes of colorectal cancer.	Nat Med	2015	https://conductscience.org/library/papers/26457759	PubMed
3	34,019,806	Conserved pan-cancer microenvironment subtypes predict response to immunotherapy.	Cancer Cell	2021	https://conductscience.org/library/papers/34019806	PubMed
4	36,656,750	Single-cell transcriptomic analyses provide insights into the cellular origins and drivers of brain metastasis from lung adenocarcinoma.	Neuro Oncol	2023	https://conductscience.org/library/papers/36656750	PubMed
5	33,659,878	Interplay between tumor microenvironment and partial EMT as the driver of tumor progression.	iScience	2021	https://conductscience.org/library/papers/33659878	PubMed
6	31,740,819	Fast, sensitive and accurate integration of single-cell data with Harmony.	Nat Methods	2019	https://conductscience.org/library/papers/31740819	PubMed
7	34,124,690	Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs.	Nat Cancer	2020	https://conductscience.org/library/papers/34124690	PubMed
8	24,925,914	Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.	Science	2014	https://conductscience.org/library/papers/24925914	PubMed
9	36,239,989	Colorectal Cancer Metastases in the Liver Establish Immunosuppressive Spatial Networking between Tumor-Associated SPP1+ Macrophages and Fibroblasts.	Clin Cancer Res	2023	https://conductscience.org/library/papers/36239989	PubMed
10	31,980,749	A framework for advancing our understanding of cancer-associated fibroblasts.	Nat Rev Cancer	2020	https://conductscience.org/library/papers/31980749	PubMed

1 to 10 of 35

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Cited by16

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 17 citations.

PMID	Title	Journal	Year	In Papers	Source
42,910,128	FLNA Expression in Cancer-Associated Fibroblasts Is Associated with Immunosuppression and Tumor Progression in Colorectal Cancer.	J Cancer	2026	https://conductscience.org/library/papers/42910128	PubMed
42,880,979	Neuro-associated SEMA3C+ tumour cells promote gastric cancer peritoneal metastasis via EBF2-FGF7-FGFR2-mediated tumour-endothelial crosstalk.	Clin Transl Med	2026	https://conductscience.org/library/papers/42880979	PubMed
42,794,806	Colitis-Associated Colorectal Cancer-STAT3 Inhibition as a Preventive Strategy.	Int J Mol Sci	2026	https://conductscience.org/library/papers/42794806	PubMed
42,688,481	Pathway-based molecular subtyping identifies LAMP5 as an EMT-associated prognostic target in colorectal cancer.	Front Pharmacol	2026	https://conductscience.org/library/papers/42688481	PubMed
42,543,026	Functional Role of ALKBH5 in Kidney Injury: Insights Into Mechanisms and Therapeutic Potential.	J Cell Biochem	2026	https://conductscience.org/library/papers/42543026	PubMed
42,530,712	Colorectal cancer-derived exosomal ETS2 promotes macrophage M2 polarization by transcriptionally activating PRPF4.	Hum Cell	2026	https://conductscience.org/library/papers/42530712	PubMed
42,497,870	A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression.	Cancer Cell	2026	https://conductscience.org/library/papers/42497870	PubMed
42,333,245	Multi-Omics Analysis Identifies Phosphoglucomutase 2 as a Potential Target to Alleviate Chemoradiotherapy Resistance in Cervical Cancer Cells.	Onco Targets Ther	2026	https://conductscience.org/library/papers/42333245	PubMed
42,304,476	Integrative spatiotemporal transcriptomics identifies a liver metastasis-related initial cell population associated with the SEMA3A-NRP1 axis in pancreatic ductal adenocarcinoma.	J Transl Med	2026	https://conductscience.org/library/papers/42304476	PubMed
41,792,569	Construction of a SEMA3 family-based model to predict prognosis and molecular subtypes in pancreatic ductal adenocarcinoma.	Discov Oncol	2026	https://conductscience.org/library/papers/41792569	PubMed

1 to 10 of 16

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
NRP2	8,828	PubTator's text mining	https://conductscience.org/library/genes/8828	NCBI Gene
SEMA3C	10,512	PubTator's text mining	https://conductscience.org/library/genes/10512	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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