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Paper · 40796751

Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity.

Kuhn J and 5 others. Nat Commun, 2025. Cited by 16 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity. Papers, record 40796751. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40796751

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity.
PubMed
Journal
Nat Commun
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
16
iCite
Relative citation ratio, by iCite
3.92, provisional
iCite
Revised in PubMed
2025-08-26
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kuhn JJonathanhttps://orcid.org/0000-0003-2355-8982
2Banerjee PParijat
3Haye AAndrew
4Robinson DNDouglas Nhttps://orcid.org/0000-0003-1236-4891
5Iglesias PAPablo Ahttps://orcid.org/0000-0002-0840-155X
6Devreotes PNPeter Nhttps://orcid.org/0000-0002-3260-1455

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell PolarityMajor topic
Signal TransductionMajor topic
CytoskeletonMajor topic
Feedback, PhysiologicalMajor topic
Dictyostelium
Humans
Actins
Phosphatidylinositol 3-Kinases
Myosin Type II
Neutrophils
ras Proteins
Chemotaxis
Cell Movement

Source PubMed

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 GM066817NIGMS NIH HHSUnited StatesR01GM066817PubMed and NIHNIH RePORTER
R01 GM149073NIGMS NIH HHSUnited StatesR01GM149073PubMed and NIHNIH RePORTER
AFOSR MURI FA95501610052United States Department of Defense | United States Air Force | AFMC | Air Force Research Laboratory (AFRL)PubMedPubMed
S10 OD016374NIH HHSUnited StatesS10OD016374PubMed and NIHNIH RePORTER
DARPA HR0011-16-C-0139United States Department of Defense | Defense Advanced Research Projects Agency (DARPA)PubMedPubMed
R35 GM118177NIGMS NIH HHSUnited StatesR35GM118177PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Update of38,405,988

Source PubMed

References96

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
132,848,0734-Hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis.Proc Natl Acad Sci U S A2020https://conductscience.org/library/papers/32848073PubMed
229,328,918Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement.Cell2018https://conductscience.org/library/papers/29328918PubMed
328,847,951Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity.Proc Natl Acad Sci U S A2017https://conductscience.org/library/papers/28847951PubMed
414,595,105Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia.Mol Biol Cell2003https://conductscience.org/library/papers/14595105PubMed
518,652,669Modeling cellular deformations using the level set formalism.BMC Syst Biol2008https://conductscience.org/library/papers/18652669PubMed
627,821,730Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks.Proc Natl Acad Sci U S A2016https://conductscience.org/library/papers/27821730PubMed
79,548,725A role for Dictyostelium racE in cortical tension and cleavage furrow progression.J Cell Biol1998https://conductscience.org/library/papers/9548725PubMed
824,846,395Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes.Cell Mol Life Sci2014https://conductscience.org/library/papers/24846395PubMed
910,444,381Orientation of chemotactic cells and growth cones: models and mechanisms.J Cell Sci1999https://conductscience.org/library/papers/10444381PubMed
1038,036,511A dynamic partitioning mechanism polarizes membrane protein distribution.Nat Commun2023https://conductscience.org/library/papers/38036511PubMed

1 to 10 of 96

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Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 16 citations.

PMIDTitleJournalYearIn PapersSource
42,910,091Janus-structured piezoelectric membrane couples barrier protection with pathological microenvironment-responsive bioactivity for periodontal bone regeneration.Bioact Mater2027https://conductscience.org/library/papers/42910091PubMed
42,901,885PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration.Nat Commun2026https://conductscience.org/library/papers/42901885PubMed
42,807,774Coordinated Arp2/3-mediated actin branching and myosin-dependent force generation in membrane-cytoskeleton remodeling.Front Physiol2026https://conductscience.org/library/papers/42807774PubMed
42,507,015Stochastic models for cell polarization and crawling: journey from external fluctuations in reaction-diffusion system to internal noise effects.Eur Biophys J2026https://conductscience.org/library/papers/42507015PubMed
42,463,668Reconstitution of Ras-PI3Kγ membrane communication and feedback using light-induced signaling inputs.Nat Commun2026https://conductscience.org/library/papers/42463668PubMed
42,319,936Mitotic Cdc42 waves encode PI(3,4)P2 signaling and Golgi morphological state to control spindle scaling.Sci Adv2026https://conductscience.org/library/papers/42319936PubMed
42,316,814Membrane Kymograph Generator: a cross-platform GUI software for automated generation and analysis of kymographs along dynamic cell boundaries.Bioinformatics2026https://conductscience.org/library/papers/42316814PubMed
42,227,345A Wet-and-Dry Research Model: Unveiling Biomechanics in Odontoblast Polarization.Int Endod J2026https://conductscience.org/library/papers/42227345PubMed
41,726,963Membrane Kymograph Generator: A cross-platform GUI software for automated generation and analysis of kymographs along dynamic cell boundaries.bioRxiv2026https://conductscience.org/library/papers/41726963PubMed
41,565,971Establishing functional giant Dictyostelium cells reveals front-rear polarity in intracellular signaling.Commun Biol2026https://conductscience.org/library/papers/41565971PubMed

1 to 10 of 17

See all 17 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
PIK3CB5,291PubTator's text mininghttps://conductscience.org/library/genes/5291

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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