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Paper · 410021

Cloning of an immunoglobulin variable region gene from mouse embryo.

Tonegawa S and 3 others. Proc Natl Acad Sci U S A, 1977. Cited by 98 papers, by iCite.

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ConductScience Library. Cloning of an immunoglobulin variable region gene from mouse embryo. Papers, record 410021. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/410021

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Cloning of an immunoglobulin variable region gene from mouse embryo.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
98
iCite
Relative citation ratio, by iCite
2.04
iCite
Revised in PubMed
2019-05-01
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Tonegawa SS
2Brack CC
3Hozumi NN
4Schuller RR

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Binding Sites, AntibodyMajor topic
ColiphagesMajor topic
DNA, RecombinantMajor topic
Escherichia coliMajor topic
GenesMajor topic
Immunoglobulin Light ChainsMajor topic
Immunoglobulin Variable RegionMajor topic
Immunoglobulin lambda-ChainsMajor topic
Animals
Chromosome Mapping
Clone Cells
DNA Ligases
Embryo, Mammalian
Mice
Microscopy, Electron
Nucleic Acid Hybridization
Transfection

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References26

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,069,257Integration of eukaryotic genes for 5S RNA and histone proteins into a phage lambda receptor.Nucleic Acids Res1976https://conductscience.org/library/papers/1069257PubMed
2408,084Somatic changes in the content and context of immunoglobulin genes.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/408084PubMed
3402,222The structural organization of ribosomal DNA in Drosophila melanogaster.Cell1977https://conductscience.org/library/papers/402222PubMed
4322,279Screening lambdagt recombinant clones by hybridization to single plaques in situ.Science1977https://conductscience.org/library/papers/322279PubMed
5824,647Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/824647PubMed
6786,462Isolation of bacteriophage lambda containing yeast ribosomal RNA genes: screening by in situ RNA hybridization to plaques.Cell1976https://conductscience.org/library/papers/786462PubMed
74,600,264Replication and transcription of eukaryotic DNA in Escherichia coli.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4600264PubMed
8781,674Hybridization of RNA to double-stranded DNA: formation of R-loops.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/781674PubMed
94,342,968Biochemical method for inserting new genetic information into DNA of Simian Virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4342968PubMed
104,352,649A general method of gene isolation.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4352649PubMed

1 to 10 of 26

See all 26 references

Cited by30

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 98 citations.

PMIDTitleJournalYearIn PapersSource
38,967,751Comparison of Non B-Ig and B-Ig.Adv Exp Med Biol2024https://conductscience.org/library/papers/38967751PubMed
38,967,746Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future.Adv Exp Med Biol2024https://conductscience.org/library/papers/38967746PubMed
36,081,500Application of recombinant antibodies for treatment of Clostridioides difficile infection: Current status and future perspective.Front Immunol2022https://conductscience.org/library/papers/36081500PubMed
24,271,582The applications of synthetic oligonucleotides to molecular biology.Pharm Res1986https://conductscience.org/library/papers/24271582PubMed
13,679,630Recombinant antibodies for the diagnosis and treatment of cancer.Mol Biotechnol2003https://conductscience.org/library/papers/13679630PubMed
12,437,786Medical immunology: a new journal for a new subspecialty.Med Immunol2002https://conductscience.org/library/papers/12437786PubMed
9,279,386Characterization of mouse cellular deoxyribonucleic acid homologous to Abelson murine leukemia virus-specific sequences.Mol Cell Biol1981https://conductscience.org/library/papers/9279386PubMed
6,791,160Organization of four mouse lambda light chain immunoglobulin genes.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6791160PubMed
6,769,120Exon shuffling generates an immunoglobulin heavy chain gene.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6769120PubMed
6,611,823Development of the National Institutes of Health Guidelines for Recombinant DNA Research.Public Health Rep1983https://conductscience.org/library/papers/6611823PubMed

1 to 10 of 30

See all 30 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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