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Paper4100684

The rapid induction by phytohemagglutinin of increased alpha-aminoisobutyric acid uptake by lymphocytes.

Mendelsohn J and 2 others. J Clin Invest, 1971. Cited by 222 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The rapid induction by phytohemagglutinin of increased alpha-aminoisobutyric acid uptake by lymphocytes. Papers, record 4100684. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4100684

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The rapid induction by phytohemagglutinin of increased alpha-aminoisobutyric acid uptake by lymphocytes.
PubMed
Journal
J Clin Invest
PubMed
Year
1971
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
222
iCite
Relative citation ratio, by iCite
6.36
iCite
Revised in PubMed
2018-11-13
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Mendelsohn JJ
2Skinner AA
3Kornfeld SS

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Aminoisobutyric AcidsMajor topic
LectinsMajor topic
LymphocytesMajor topic
Alpha-Globulins
Biological Transport
Carbon Isotopes
Culture Techniques
Cycloheximide
DNA
Diffusion
Humans
Kinetics
Puromycin
Stimulation, Chemical
Thymidine

Source PubMed

References17

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,656,399Studies on lysosomes. XII. Redistribution of acid hydrolases in human lymphocytes stimulated by phytohemagglutinin.J Cell Biol1968https://conductscience.org/library/papers/5656399PubMed
24,190,859[Endocytotic capacity of normal and in vitro transformed guinea pig lymph node lymphocytes].Ann Inst Pasteur (Paris)1969https://conductscience.org/library/papers/4190859PubMed
45,963,252Cytoplasmic localization of phytohaemagglutinin in peripheral white cells.Nature1966https://conductscience.org/library/papers/5963252PubMed
55,445,799The structure of a phytohemagglutinin receptor site from human erythrocytes.J Biol Chem1970https://conductscience.org/library/papers/5445799PubMed
65,368,257Decreased phytohemagglutinin receptor sites in chronic lymphocytic leukemia.Biochim Biophys Acta1969https://conductscience.org/library/papers/5368257PubMed
76,031,896Separation of lymphocyte-stimulating and agglutinating activities in phytohaemagglutinin (PHA) from Phaseolus vulgaris.Scand J Haematol1967https://conductscience.org/library/papers/6031896PubMed
913,675,766Amino acid metabolism in mammalian cell cultures.Science1959https://conductscience.org/library/papers/13675766PubMed
1013,901,578A new method for preparing buffy coat-poor blood.Transfusion1962https://conductscience.org/library/papers/13901578PubMed
114,306,034Transport of amino acids by confluent and nonconfluent 3T3 and polyoma virus-transformed 3T3 cells growing on glass cover slips.J Biol Chem1969https://conductscience.org/library/papers/4306034PubMed
125,690,132On the synthesis of RNA in lymphocytes stimulated by phytohemagglutinin. 1. Induction of uridine-kinase and the conversion of uridine to UTP.Eur J Biochem1968https://conductscience.org/library/papers/5690132PubMed
1314,165,602CELLULAR LOCALIZATION OF THE MITOGENIC PRINCIPLE OF PHYTOHAEMAGGLUTININ IN LEUCOCYTE CULTURES.Exp Cell Res1964https://conductscience.org/library/papers/14165602PubMed
145,697,393Purification of lymphocytes and platelets by gradient centrifugation.J Lab Clin Med1968https://conductscience.org/library/papers/5697393PubMed
156,025,543Pyrimidine nucleotide synthesis: regulatory control during transformation of lymphocytes in vitro.Science1967https://conductscience.org/library/papers/6025543PubMed
1613,906,342Amino acid transport in lymph node cells.J Biol Chem1962https://conductscience.org/library/papers/13906342PubMed
174,299,946An early alteration in the phospholipid metabolism of lymphocytes by phytohemagglutinin.Proc Natl Acad Sci U S A1968https://conductscience.org/library/papers/4299946PubMed
1814,493,965Transport of amino acids by slices of rat-kidney cortex.Biochim Biophys Acta1961https://conductscience.org/library/papers/14493965PubMed
195,219,687RNA synthesis and histone acetylation during the course of gene activation in lymphocytes.Proc Natl Acad Sci U S A1966https://conductscience.org/library/papers/5219687PubMed

Cited by60

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 222 citations.

PMIDTitleJournalYearIn PapersSource
37,512,013Effects of High-Intensity Interval Training on Melatonin Function and Cellular Lymphocyte Apoptosis in Sedentary Middle-Aged Men.Medicina (Kaunas)2023https://conductscience.org/library/papers/37512013PubMed
35,398,357Sialoglycan-binding patterns of bacterial AB5 toxin B subunits correlate with host range and toxicity, indicating evolution independent of A subunits.J Biol Chem2022https://conductscience.org/library/papers/35398357PubMed
26,346,312System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis.Immunology2015https://conductscience.org/library/papers/26346312PubMed
7,353,081Adenine and hypoxanthine metabolism in phythohemagglutinin-stimulated and unstimulated human lymphocytes.Blut1980https://conductscience.org/library/papers/7353081PubMed
6,947,229Lectins activate lymphocyte pyruvate dehydrogenase by a mechanism sensitive to protease inhibitors.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6947229PubMed
6,787,080Role of insulin in the intermediary metabolism of the activated thymic-derived lymphocyte.J Clin Invest1981https://conductscience.org/library/papers/6787080PubMed
6,424,638Amino acid transport in human tonsillar lymphocytes with regard to patient's age and tonsillar diseases.Arch Otorhinolaryngol1984https://conductscience.org/library/papers/6424638PubMed
6,310,579Nucleotide-stimulated proteolysis of histone H1.Proc Natl Acad Sci U S A1983https://conductscience.org/library/papers/6310579PubMed
6,275,850Amino acid transport and rubidium-ion uptake in monolayer cultures of hepatocytes from neonatal rats.Biochem J1981https://conductscience.org/library/papers/6275850PubMed
6,176,325Early electrochemical events in lectin-lymphocyte interaction. I. Mechanism of lectin-mediated changes in the electrophoretic mobility of lymphocytes.Cell Biophys1982https://conductscience.org/library/papers/6176325PubMed
6,156,040Fluorescent probes to detect lymphocyte activation.Clin Exp Immunol1980https://conductscience.org/library/papers/6156040PubMed
5,060,291Production of macrophage migration inhibition factor by continuous cell lines.J Exp Med1972https://conductscience.org/library/papers/5060291PubMed
5,054,470Alpha-aminoisobutyric acid transport in human leukemic lymphocytes: in vitro characteristics and inhibition by cortisol and cycloheximide.J Clin Invest1972https://conductscience.org/library/papers/5054470PubMed
4,819,306Characterization of lymphocyte transformation induced by zinc ions.J Cell Biol1974https://conductscience.org/library/papers/4819306PubMed
4,664,603The induction of ornithine decarboxylase during lymphocyte stimulation by phytohaemagglutinin.Biochem J1972https://conductscience.org/library/papers/4664603PubMed
4,640,956Studies of two subpopulations of human lymphocytes differing in responsiveness to concanavalin A.J Clin Invest1972https://conductscience.org/library/papers/4640956PubMed
4,640,952Lymphocyte transformation induced by autologous cells: stimulation by cultured lymphoblast lines.J Clin Invest1972https://conductscience.org/library/papers/4640952PubMed
4,623,260The immunological and physicochemical properties of mitogenic proteins derived from Phaseolus vulgaris.Immunology1972https://conductscience.org/library/papers/4623260PubMed
4,505,646Excretion of deoxyribonucleic acid by lymphocytes stimulated with phytohemagglutinin or antigen.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4505646PubMed
4,404,909Alterations in cyclic adenosine monophosphate metabolism in human bronchial asthma. I. Leukocyte responsiveness to -adrenergic agents.J Clin Invest1973https://conductscience.org/library/papers/4404909PubMed

See all 60 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

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  • ClinicalTrials.govNo license stated
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  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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