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Paper41212554

Role of complexin 2 in the regulation of hormone secretion from the islet of Langerhans.

Ng XW and 4 others. Am J Physiol Endocrinol Metab, 2025. Cited by 1 paper, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Role of complexin 2 in the regulation of hormone secretion from the islet of Langerhans. Papers, record 41212554. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41212554

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Role of complexin 2 in the regulation of hormone secretion from the islet of Langerhans.
PubMed
Journal
Am J Physiol Endocrinol Metab
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
1
iCite
Revised in PubMed
2026-08-13
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ng XWXue Wenhttps://orcid.org/0000-0001-6252-8052
2Kong CChen
3DiGruccio MRMichael R
4Lee JJeongminhttps://orcid.org/0000-0003-2554-4285
5Piston DWDavid Whttps://orcid.org/0000-0002-1200-3116

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
SomatostatinMajor topic
GlucagonMajor topic
Islets of LangerhansMajor topic
Insulin SecretionMajor topic
Nerve Tissue ProteinsMajor topic
InsulinMajor topic
Adaptor Proteins, Vesicular TransportMajor topic
Animals
Mice
Mice, Knockout
Somatostatin-Secreting Cells
Insulin-Secreting Cells
Exocytosis
Glucagon-Secreting Cells
Male
Mice, Inbred C57BL
Glucose

Source PubMed

Grants9

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 DK115972NIDDK NIH HHSUnited StatesR01DK115972PubMed and NIHNIH RePORTER
R01DK115972HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM)R01DK115972PubMed and NIHNIH RePORTER
R01DK123301HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM)R01DK123301PubMed and NIHNIH RePORTER
R01 DK123301NIDDK NIH HHSUnited StatesR01DK123301PubMed and NIHNIH RePORTER
P30 DK020579NIDDK NIH HHSUnited StatesP30DK020579PubMed and NIHNIH RePORTER
G-1912-03558Leona M. and Harry B. Helmsley Charitable Trust (Helmsley)PubMedPubMed
G-2305-06050Leona M. and Harry B. Helmsley Charitable Trust (Helmsley)PubMedPubMed
P30DK020579HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM)P30DK020579PubMed and NIHNIH RePORTER
G-2001-04215Leona M. and Harry B. Helmsley Charitable Trust (Helmsley)PubMedPubMed

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Update of39,554,053Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans.https://conductscience.org/library/papers/39554053

Source PubMed

References57

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
19,753,100Regulatory roles of complexins in neurotransmitter release from mature presynaptic nerve terminals.Eur J Neurosci1998https://conductscience.org/library/papers/9753100PubMed
216,845,390Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I.Nat Struct Mol Biol2006https://conductscience.org/library/papers/16845390PubMed
325,613,900Proteomics. Tissue-based map of the human proteome.Science2015https://conductscience.org/library/papers/25613900PubMed
48,769,372Binding properties of somatostatin receptor subtypes.Metabolism1996https://conductscience.org/library/papers/8769372PubMed
519,033,464Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming.Proc Natl Acad Sci U S A2008https://conductscience.org/library/papers/19033464PubMed
636,316,316Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis.Nat Commun2022https://conductscience.org/library/papers/36316316PubMed
721,785,413Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state.Nat Struct Mol Biol2011https://conductscience.org/library/papers/21785413PubMed
837,836,562Type 1 and Type 2 Diabetes Mellitus: Commonalities, Differences and the Importance of Exercise and Nutrition.Nutrients2023https://conductscience.org/library/papers/37836562PubMed
915,870,114Complexin II facilitates exocytotic release in mast cells by enhancing Ca2+ sensitivity of the fusion process.J Cell Sci2005https://conductscience.org/library/papers/15870114PubMed
106,440,208The topography of electrical synchrony among beta-cells in the mouse islet of Langerhans.Q J Exp Physiol1984https://conductscience.org/library/papers/6440208PubMed
1130,840,877Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release.Cell Rep2019https://conductscience.org/library/papers/30840877PubMed
1211,163,241Complexins regulate a late step in Ca2+-dependent neurotransmitter release.Cell2001https://conductscience.org/library/papers/11163241PubMed
1325,500,700Ins1(Cre) knock-in mice for beta cell-specific gene recombination.Diabetologia2015https://conductscience.org/library/papers/25500700PubMed
1429,212,789Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Physiol Rev2018https://conductscience.org/library/papers/29212789PubMed
1527,207,520Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells.Diabetes2016https://conductscience.org/library/papers/27207520PubMed
1615,126,625Complexin I regulates glucose-induced secretion in pancreatic beta-cells.J Cell Sci2004https://conductscience.org/library/papers/15126625PubMed
1738,568,977Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion.Proc Natl Acad Sci U S A2024https://conductscience.org/library/papers/38568977PubMed
1811,024,017Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta -cell.J Biol Chem2000https://conductscience.org/library/papers/11024017PubMed
1917,873,870A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth.Nat Neurosci2007https://conductscience.org/library/papers/17873870PubMed
2011,832,227Three-dimensional structure of the complexin/SNARE complex.Neuron2002https://conductscience.org/library/papers/11832227PubMed

See all 57 references

Cited by1

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1 citation.

PMIDTitleJournalYearIn Papers
42,625,306Stathmin-2 mediates paracrine hormone regulation of glucagon through lysosomal trafficking in αTC1-6 cells.J Physiol2026https://conductscience.org/library/papers/42625306

Source PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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