Paper · 41309656

Midbrain extracellular matrix and microglia are associated with cognition in aging mice.

Gray DT and 8 others. Nat Commun, 2025. Cited by 2 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Midbrain extracellular matrix and microglia are associated with cognition in aging mice. Papers, record 41309656. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41309656

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Midbrain extracellular matrix and microglia are associated with cognition in aging mice.; PubMed
Journal: Nat Commun; PubMed
Year: 2025; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/41309656/; PubMed
DOI: https://doi.org/10.1038/s41467-025-66434-z; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12722224/; PubMed
The journal: https://conductscience.org/library/journal-index/101528555; PubMed
Citations, by iCite: 2; iCite
Revised in PubMed: 2025-12-26; PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Gray DT	Daniel T	https://orcid.org/0000-0001-6262-5178
2	Gutierrez A	Abigail
3	Jami-Alahmadi Y	Yasaman
4	Pandey V	Vijaya
5	Pan L	Lin
6	Zhang Y	Ye
7	Wohlschlegel JA	James A	https://orcid.org/0000-0003-3399-901X
8	McDevitt RA	Ross A	https://orcid.org/0000-0003-3722-9047
9	De Biase LM	Lindsay M	https://orcid.org/0000-0003-0177-5601

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Microglia	Major topic
Extracellular Matrix	Major topic
Aging	Major topic
Cognition	Major topic
Mesencephalon	Major topic
Animals
Mice
Male
Synapses
Mice, Inbred C57BL
Proteomics
Hyaluronic Acid
Proteoglycans

Source PubMed

Grants9

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R01DA059873	U.S. Department of Health & Human Services \| NIH \| National Institute on Drug Abuse (NIDA)		R01DA059873	PubMed and NIH	NIH RePORTER
R01 NS109025	NINDS NIH HHS	United States	R01NS109025	PubMed and NIH	NIH RePORTER
P50 HD103557	NICHD NIH HHS	United States	P50HD103557	PubMed and NIH	NIH RePORTER
MCKNIGHT21003	American Federation for Aging Research (American Federation for Aging Research, Inc.)			PubMed	PubMed
1R01AG075909-01	U.S. Department of Health & Human Services \| NIH \| National Institute on Aging (U.S. National Institute on Aging)		R01AG075909	PubMed and NIH	NIH RePORTER
R01 AG075909	NIA NIH HHS	United States	R01AG075909	PubMed and NIH	NIH RePORTER
SFI-AN-NC-AB-Independence Postdoctoral-00007445	Simons Foundation			PubMed	PubMed
P50HD103557	U.S. Department of Health & Human Services \| NIH \| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)		P50HD103557	PubMed and NIH	NIH RePORTER
R01 DA059873	NIDA NIH HHS	United States	R01DA059873	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References106

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	30,053,789	Framingham vascular age is associated with worse cognitive performance in the middle-aged and elderly.	Neuropsychol Dev Cogn B Aging Neuropsychol Cogn	2019	https://conductscience.org/library/papers/30053789	PubMed
2	20,880,501	Role of microglia in neurotrauma.	Neurotherapeutics	2010	https://conductscience.org/library/papers/20880501	PubMed
3	37,653,256	The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance.	Nat Aging	2023	https://conductscience.org/library/papers/37653256	PubMed
4	29,134,267	Complement in the pathogenesis of Alzheimer's disease.	Semin Immunopathol	2018	https://conductscience.org/library/papers/29134267	PubMed
5	24,490,760	CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke.	J Neuroinflammation	2014	https://conductscience.org/library/papers/24490760	PubMed
6	1,789,684	Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.	Ann Neurol	1991	https://conductscience.org/library/papers/1789684	PubMed
7	22,615,373	Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.	Proc Natl Acad Sci U S A	2012	https://conductscience.org/library/papers/22615373	PubMed
8	37,108,212	Extracellular Matrix Regulation in Physiology and in Brain Disease.	Int J Mol Sci	2023	https://conductscience.org/library/papers/37108212	PubMed
9	30,528,194	Activity-Induced Amyloid-β Oligomers Drive Compensatory Synaptic Rearrangements in Brain Circuits Controlling Memory of Presymptomatic Alzheimer's Disease Mice.	Biol Psychiatry	2019	https://conductscience.org/library/papers/30528194	PubMed
10	20,729,843	Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons.	Nat Neurosci	2010	https://conductscience.org/library/papers/20729843	PubMed

1 to 10 of 106

See all 106 references

Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2 citations.

PMID	Title	Journal	Year	In Papers	Source
42,983,715	Transcriptomic insights into age-associated extracellular matrix promotion of breast cancer.	BMC Biol	2026	https://conductscience.org/library/papers/42983715	PubMed
42,934,239	Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors in mice.	Nat Commun	2026	https://conductscience.org/library/papers/42934239	PubMed
41,676,692	COUNTERING AGE-ASSOCIATED ALTERATIONS IN OLIGODENDROCYTE-DERIVED EXTRACELLULAR MATRIX REJUVENATES COGNITION.	bioRxiv	2026	https://conductscience.org/library/papers/41676692	PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/41309656

GET https://conductscience.org/api/papers/v1/41309656/references?page=2

API reference For AI assistants