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Paper · 41369776

Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis.

Verhoeven A and 2 others. Arch Toxicol, 2026. Cited by 2 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis. Papers, record 41369776. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41369776

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis.
PubMed
Journal
Arch Toxicol
PubMed
Year
2026
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
2
iCite
Revised in PubMed
2026-05-04
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Verhoeven AAnoukhttps://orcid.org/0000-0003-1275-9498
2Sanz-Serrano JJulenhttps://orcid.org/0000-0002-0503-2752
3Vinken MMathieuhttps://orcid.org/0000-0001-5115-8893

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Fatty LiverMajor topic
Adverse Outcome PathwaysMajor topic
Toxicity TestsMajor topic
Chemical and Drug Induced Liver InjuryMajor topic
Humans
Animals
Risk Assessment
Animal Testing Alternatives

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References315

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
137,195,416Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids.Toxicol Sci2023https://conductscience.org/library/papers/37195416PubMed
224,582,757Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment.Toxicology2015https://conductscience.org/library/papers/24582757PubMed
329,551,309Mitochondrial β-oxidation of saturated fatty acids in humans.Mitochondrion2019https://conductscience.org/library/papers/29551309PubMed
430,279,702Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity.Front Genet2018https://conductscience.org/library/papers/30279702PubMed
526,394,026Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death.Biochem Pharmacol2015https://conductscience.org/library/papers/26394026PubMed
619,854,160Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis.Biochem Pharmacol2010https://conductscience.org/library/papers/19854160PubMed
734,778,935Investigating the in vitro steatotic mixture effects of similarly and dissimilarly acting test compounds using an adverse outcome pathway-based approach.Arch Toxicol2022https://conductscience.org/library/papers/34778935PubMed
831,250,071Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.Arch Toxicol2019https://conductscience.org/library/papers/31250071PubMed
932,503,331Exploring the Lipidome: Current Lipid Extraction Techniques for Mass Spectrometry Analysis.Metabolites2020https://conductscience.org/library/papers/32503331PubMed
1025,326,588Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents.Toxicol Pathol2015https://conductscience.org/library/papers/25326588PubMed

1 to 10 of 315

See all 315 references

Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2 citations.

PMIDTitleJournalYearIn PapersSource
42,965,594Combined exposure to triphenyl phosphate and haloperidol alters hepatic lipid homeostasis and xenobiotic metabolism beyond single-compound effects.Arch Toxicol2026https://conductscience.org/library/papers/42965594PubMed
42,915,720Refinement of Structural Alerts for Hepatic Steatosis.Chem Res Toxicol2026https://conductscience.org/library/papers/42915720PubMed
42,233,048Cardiotoxicity adverse outcome pathway network: towards mechanistic and quantitative modelling.Front Toxicol2026https://conductscience.org/library/papers/42233048PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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