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Paper · 4153003

Positive inotropic effects of phenylephrine in the isolated rabbit papillary muscle mediated both by alpha- and beta-adrenoceptors.

Schümann HJ and 2 others. Naunyn Schmiedebergs Arch Pharmacol, 1974. Cited by 163 papers, by iCite.

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ConductScience Library. Positive inotropic effects of phenylephrine in the isolated rabbit papillary muscle mediated both by alpha- and beta-adrenoceptors. Papers, record 4153003. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4153003

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Positive inotropic effects of phenylephrine in the isolated rabbit papillary muscle mediated both by alpha- and beta-adrenoceptors.
PubMed
Journal
Naunyn Schmiedebergs Arch Pharmacol
PubMed
Year
1974
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
163
iCite
Relative citation ratio, by iCite
6.21
iCite
Revised in PubMed
2019-07-25
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Schümann HJH J
2Endo MM
3Wagner JJ

Source PubMed

Topics26

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
MusclesMajor topic
PhenylephrineMajor topic
Receptors, AdrenergicMajor topic
Adrenergic alpha-Agonists
Adrenergic alpha-Antagonists
Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Animals
Depression, Chemical
Epinephrine
Heart
In Vitro Techniques
Isoproterenol
Methoxamine
Naphazoline
Norepinephrine
Oxymetazoline
Papaverine
Papillary Muscles
Phentolamine
Phosphodiesterase Inhibitors
Pindolol
Rabbits
Reserpine
Stimulation, Chemical
Theophylline

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References25

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,403,611Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart.Naunyn Schmiedebergs Arch Pharmacol1972https://conductscience.org/library/papers/4403611PubMed
25,441,156Blockade of the cardiac action of phenylephrine by bretylium or cocaine.J Pharmacol Exp Ther1970https://conductscience.org/library/papers/5441156PubMed
34,277,020Stimulation by phenylephrine of adrenergic alpha- and beta-receptors in the isolated perfused rabbit heart.Naunyn Schmiedebergs Arch Pharmacol1974https://conductscience.org/library/papers/4277020PubMed
44,320,455Inhibition of cyclic-3',5'-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs.Naunyn Schmiedebergs Arch Pharmakol1970https://conductscience.org/library/papers/4320455PubMed
54,354,544Effect of catecholamines, histamine and oxyfedrine on isotonic contraction and cyclic AMP in the guinea-pig heart.Naunyn Schmiedebergs Arch Pharmacol1973https://conductscience.org/library/papers/4354544PubMed
613,651,579Some quantitative uses of drug antagonists.Br J Pharmacol Chemother1959https://conductscience.org/library/papers/13651579PubMed
74,347,075Role of cyclic AMP and Ca ++ in mechanical and metabolic events in isometrically contracting vascular smooth muscle.Acta Physiol Scand1973https://conductscience.org/library/papers/4347075PubMed
813,990,605The potentiation of cardiac inotropic responses to norepinephrine by theophylline.J Pharmacol Exp Ther1963https://conductscience.org/library/papers/13990605PubMed
94,397,537The adrenergic receptors of the coronary circulation in the isolated dog heart.Arch Int Pharmacodyn Ther1969https://conductscience.org/library/papers/4397537PubMed
104,384,517Myocardial alpha adrenergic receptors and their role in the production of a positive inotropic effect by sympathomimetic agents.J Pharmacol Exp Ther1968https://conductscience.org/library/papers/4384517PubMed

1 to 10 of 25

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Cited by35

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 163 citations.

PMIDTitleJournalYearIn PapersSource
35,945,308The Pharmacological Effects of Phenylephrine are Indirect, Mediated by Noradrenaline Release from the Cytoplasm.Neurochem Res2022https://conductscience.org/library/papers/35945308PubMed
18,846,0355-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles.Br J Pharmacol2008https://conductscience.org/library/papers/18846035PubMed
8,401,934Induction by endogenous noradrenaline of an alpha 1-adrenoceptor-mediated positive inotropic effect in rabbit papillary muscles.Br J Pharmacol1993https://conductscience.org/library/papers/8401934PubMed
7,279,006The positive inotropic effect of (-)-noradrenaline and (+/-)-isoprenaline after chemical sympathectomy: evidence in favour of differences at a postsynaptic site.Naunyn Schmiedebergs Arch Pharmacol1981https://conductscience.org/library/papers/7279006PubMed
6,652,341Age-dependent differences in the positive inotropic effect of phenylephrine on rat isolated atria.Br J Pharmacol1983https://conductscience.org/library/papers/6652341PubMed
6,281,673alpha-Adrenoceptors mediating the positive inotropic effect of phenylephrine in the right ventricular muscle of the monkey (Macaca fuscata).Naunyn Schmiedebergs Arch Pharmacol1982https://conductscience.org/library/papers/6281673PubMed
6,254,592alpha-Sympathomimetic amines and calcium-mediated action potentials in guinea-pig ventricular muscle.Br J Pharmacol1980https://conductscience.org/library/papers/6254592PubMed
6,248,799Stimulation by adrenaline and dopamine but not by noradrenaline of myocardial alpha-adrenoceptors mediating positive inotropic effects in human atrial preparations.Naunyn Schmiedebergs Arch Pharmacol1980https://conductscience.org/library/papers/6248799PubMed
6,126,819Influence of acetylcholine on the positive inotropic effect evoked by alpha- or beta-adrenoceptor stimulation in the rabbit heart.Naunyn Schmiedebergs Arch Pharmacol1982https://conductscience.org/library/papers/6126819PubMed
6,123,086Effect of alpha- and beta-sympathomimetic agonists on calcium-dependent slow action potential and force of contraction in the rabbit papillary muscle.Naunyn Schmiedebergs Arch Pharmacol1982https://conductscience.org/library/papers/6123086PubMed

1 to 10 of 35

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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