Paper · 4158937

Studies on the macroglobulins of human serum. I. Polyclonal immunoglobulin class M (IgM) increase in infectious mononucleosis.

Wollheim FA and 1 other. N Engl J Med, 1966. Cited by 141 papers, by iCite.

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ConductScience Library. Studies on the macroglobulins of human serum. I. Polyclonal immunoglobulin class M (IgM) increase in infectious mononucleosis. Papers, record 4158937. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4158937

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Studies on the macroglobulins of human serum. I. Polyclonal immunoglobulin class M (IgM) increase in infectious mononucleosis.; PubMed
Journal: N Engl J Med; PubMed
Year: 1966; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/4158937/; PubMed
DOI: https://doi.org/10.1056/nejm196601132740202; PubMed
The journal: https://conductscience.org/library/journal-index/0255562; PubMed
Citations, by iCite: 141; iCite
Revised in PubMed: 2014-11-20; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Wollheim FA	F A
2	Williams RC Jr	R C

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Autoantibodies	Major topic
Infectious Mononucleosis	Major topic
Macroglobulins	Major topic
gamma-Globulins	Major topic
Absorption
Adult
Agglutination
Female
Humans
Immunoelectrophoresis
In Vitro Techniques
Male

Source PubMed

Grants0

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None in this release.

Trials0

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None in this release.

Comments and corrections0

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References0

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Cited by25

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 141 citations.

PMID	Title	Journal	Year	In Papers	Source
32,331,303	Limited Utility of Serology and Heterophile Test in the Early Diagnosis of Epstein-Barr Virus Mononucleosis in a Child after Renal Transplantation.	Medicines (Basel)	2020	https://conductscience.org/library/papers/32331303	PubMed
32,188,754	Microsphere-Based IgM and IgG Avidity Assays for Human Parvovirus B19, Human Cytomegalovirus, and Toxoplasma gondii.	mSphere	2020	https://conductscience.org/library/papers/32188754	PubMed
27,123,464	Selective Subnormal IgG1 in 54 Adult Index Patients with Frequent or Severe Bacterial Respiratory Tract Infections.	J Immunol Res	2016	https://conductscience.org/library/papers/27123464	PubMed
6,993,069	Antitubulin antibody in healthy adults and patients with infectious mononucleosis and its relationship to smooth muscle antibody (SMA).	Clin Exp Immunol	1980	https://conductscience.org/library/papers/6993069	PubMed
6,456,093	Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis.	Clin Exp Immunol	1981	https://conductscience.org/library/papers/6456093	PubMed
6,264,016	Plasmacytic differentiation of circulating Epstein-Barr virus-infected B lymphocytes during acute infectious mononucleosis.	J Exp Med	1981	https://conductscience.org/library/papers/6264016	PubMed
6,087,121	Human monoclonal antibodies.	Mol Cell Biochem	1984	https://conductscience.org/library/papers/6087121	PubMed
4,962,069	Synthesis of macroglobulins in vitro.	Nature	1967	https://conductscience.org/library/papers/4962069	PubMed
4,549,622	T- and B-cell subpopulations in infectious mononucleosis.	Clin Exp Immunol	1974	https://conductscience.org/library/papers/4549622	PubMed
4,376,156	The EB virus in relation to infectious mononucleosis.	J Clin Pathol Suppl (R Coll Pathol)	1972	https://conductscience.org/library/papers/4376156	PubMed

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Genes0

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None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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