Paper · 41839715

A conundrum resolved: regulation and activation of UvrD-family DNA helicases/translocases.

Lohman TM and 4 others. Trends Biochem Sci, 2026. Cited by 3 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. A conundrum resolved: regulation and activation of UvrD-family DNA helicases/translocases. Papers, record 41839715. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41839715

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A conundrum resolved: regulation and activation of UvrD-family DNA helicases/translocases.; PubMed
Journal: Trends Biochem Sci; PubMed
Year: 2026; PubMed
Publication types: Journal Article, Review, Research Support, N.I.H., Extramural; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/41839715/; PubMed
DOI: https://doi.org/10.1016/j.tibs.2026.02.005; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13238157/; PubMed
The journal: https://conductscience.org/library/journal-index/7610674; PubMed
Citations, by iCite: 3; iCite
Revised in PubMed: 2026-08-13; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Lohman TM	Timothy M
2	Mersch KN	Kacey N
3	Chadda A	Ankita
4	Nguyen B	Binh
5	Galburt EA	Eric A

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
DNA Helicases	Major topic
Escherichia coli Proteins	Major topic
Escherichia coli
Mycobacterium tuberculosis
Models, Molecular
Protein Multimerization
Enzyme Activation

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R35 GM136632	NIGMS NIH HHS	United States	R35GM136632	PubMed	NIH RePORTER
R35 GM144282	NIH HHS	United States	R35GM144282	PubMed	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References93

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	29,998,112	New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy.	Front Mol Biosci	2018	https://conductscience.org/library/papers/29998112	PubMed
2	10,199,404	Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism.	Cell	1999	https://conductscience.org/library/papers/10199404	PubMed
3	17,376,770	Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair.	J Biol Chem	2007	https://conductscience.org/library/papers/17376770	PubMed
4	16,464,007	DNA mismatch repair: functions and mechanisms.	Chem Rev	2006	https://conductscience.org/library/papers/16464007	PubMed
5	20,456,941	SF1 and SF2 helicases: family matters.	Curr Opin Struct Biol	2010	https://conductscience.org/library/papers/20456941	PubMed
6	23,393,192	Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase.	Nucleic Acids Res	2013	https://conductscience.org/library/papers/23393192	PubMed
7	40,048,277	Structural basis for dimerization and activation of UvrD-family helicases.	Proc Natl Acad Sci U S A	2025	https://conductscience.org/library/papers/40048277	PubMed
8	34,404,299	Mechanisms of hexameric helicases.	Crit Rev Biochem Mol Biol	2021	https://conductscience.org/library/papers/34404299	PubMed
9	20,383,562	Genome-wide analysis of helicase gene family from rice and Arabidopsis: a comparison with yeast and human.	Plant Mol Biol	2010	https://conductscience.org/library/papers/20383562	PubMed
10	12,374,984	Initiation and re-initiation of DNA unwinding by the Escherichia coli Rep helicase.	Nature	2002	https://conductscience.org/library/papers/12374984	PubMed

1 to 10 of 93

See all 93 references

Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 3 citations.

PMID	Title	Journal	Year	In Papers	Source
42,779,690	A superfamily 1 helicase translocates on double-stranded DNA.	bioRxiv	2026	https://conductscience.org/library/papers/42779690	PubMed
42,444,602	A conserved mechanism for dimerization and activation of superfamily 1A UvrD-family helicases.	Nucleic Acids Res	2026	https://conductscience.org/library/papers/42444602	PubMed
42,180,263	Biomolecular and cellular chirality: Novel diagnostic perspectives for diseases.	APL Bioeng	2026	https://conductscience.org/library/papers/42180263	PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/41839715

GET https://conductscience.org/api/papers/v1/41839715/references?page=2

API reference For AI assistants