Paper · 41897396

The Degeneration Paradox: Severely Degenerated Cervical Nucleus Pulposus Cells Display Enhanced Mechanoplasticity Under Moderate Cyclic Tensile Strain.

Wang Y and 8 others. Biomolecules, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The Degeneration Paradox: Severely Degenerated Cervical Nucleus Pulposus Cells Display Enhanced Mechanoplasticity Under Moderate Cyclic Tensile Strain. Papers, record 41897396. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41897396

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The Degeneration Paradox: Severely Degenerated Cervical Nucleus Pulposus Cells Display Enhanced Mechanoplasticity Under Moderate Cyclic Tensile Strain.; PubMed
Journal: Biomolecules; PubMed
Year: 2026; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/41897396/; PubMed
DOI: https://doi.org/10.3390/biom16030461; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13024720/; PubMed
The journal: https://conductscience.org/library/journal-index/101596414; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2026-08-13; PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Wang Y	Yuwen
2	Chen Y	Yi
3	Xiao B	Bowei
4	Zhang B	Baining
5	Huang J	Juying
6	Zhang N	Nan
7	Wu B	Binxuan
8	Rong T	Tianhua
9	Liu B	Baoge	https://orcid.org/0000-0002-2156-0870

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Nucleus Pulposus	Major topic
Intervertebral Disc Degeneration	Major topic
Cervical Vertebrae	Major topic
Humans
Female
Stress, Mechanical
Elastic Modulus
Male
Actins
Tensile Strength
Middle Aged
Adult
Microscopy, Atomic Force
Cytoskeleton
Cells, Cultured

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
82272524	National Natural Science Foundation of China			PubMed
Leading Talent-02-05	High-Level Public Health Technology Talent Construction Project of Beijing			PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	30,783,087	Kindlin-2 links mechano-environment to proline synthesis and tumor growth.	Nat Commun	2019	https://conductscience.org/library/papers/30783087	PubMed
2	32,040,269	Inhibition of Rac1 activity by NSC23766 prevents cartilage endplate degeneration via Wnt/β-catenin pathway.	J Cell Mol Med	2020	https://conductscience.org/library/papers/32040269	PubMed
3	24,368,833	Reversible and irreversible differentiation of cardiac fibroblasts.	Cardiovasc Res	2014	https://conductscience.org/library/papers/24368833	PubMed
4	29,426,836	Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments.	Nat Commun	2018	https://conductscience.org/library/papers/29426836	PubMed
5	18,978,580	Kinematic analysis of the relationship between sagittal alignment and disc degeneration in the cervical spine.	Spine (Phila Pa 1976)	2008	https://conductscience.org/library/papers/18978580	PubMed
6	35,743,056	Current Perspectives on Nucleus Pulposus Fibrosis in Disc Degeneration and Repair.	Int J Mol Sci	2022	https://conductscience.org/library/papers/35743056	PubMed
7	36,719,565	Effects of periodic mechanical stress on cytoskeleton dependent lipid raft-induced integrin ɑ1 activation in rat nucleus pulposus cells.	J Mol Histol	2023	https://conductscience.org/library/papers/36719565	PubMed
8	16,915,105	What is intervertebral disc degeneration, and what causes it?	Spine (Phila Pa 1976)	2006	https://conductscience.org/library/papers/16915105	PubMed
9	33,867,854	Moderate mechanical stimulation rescues degenerative annulus fibrosus by suppressing caveolin-1 mediated pro-inflammatory signaling pathway.	Int J Biol Sci	2021	https://conductscience.org/library/papers/33867854	PubMed
10	33,920,587	The Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review.	Cells	2021	https://conductscience.org/library/papers/33920587	PubMed

1 to 10 of 47

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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