Paper4200461

Transplantation of isolated pancreatic islets into the portal vein of diabetic rats.

Kemp CB and 4 others. Nature, 1973. Cited by 174 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Transplantation of isolated pancreatic islets into the portal vein of diabetic rats. Papers, record 4200461. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4200461

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Transplantation of isolated pancreatic islets into the portal vein of diabetic rats.; PubMed
Journal: Nature; PubMed
Year: 1973; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/4200461/; PubMed
DOI: https://doi.org/10.1038/244447a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 174; iCite
Relative citation ratio, by iCite: 4.07; iCite
Revised in PubMed: 2026-11-02; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Kemp CB	C B
2	Knight MJ	M J
3	Scharp DW	D W
4	Lacy PE	P E
5	Ballinger WF	W F

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Diabetes Mellitus	Major topic
Islets of Langerhans Transplantation	Major topic
Portal Vein	Major topic
Animals
Blood Glucose
Rats
Urine

Source PubMed

Show 1 more topicsShow fewer topics

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

Trial	Title	The trial lists it as	Named in the paper's record
NCT00006505	Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression	Background

Source ClinicalTrials.gov

References2

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,262,169	Transplantation of intact pancreatic islets in rats.	Surgery	1972	https://conductscience.org/library/papers/4262169	PubMed
2	5,333,500	Method for the isolation of intact islets of Langerhans from the rat pancreas.	Diabetes	1967	https://conductscience.org/library/papers/5333500	PubMed

Cited by44

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 174 citations.

PMID	Title	Journal	Year	In Papers	Source
42,789,342	A Stepwise Method to Derive Functional Pancreatic Islet-like Clusters from Human Pluripotent Stem Cells.	Curr Protoc	2026	https://conductscience.org/library/papers/42789342	PubMed
41,173,819	Effects of bivalirudin on instant blood-mediated inflammatory reaction after intraportal islet transplantation.	Cell Transplant	2025	https://conductscience.org/library/papers/41173819	PubMed
40,881,764	Islet dimension and its impact on transplant outcome: A systematic review.	World J Transplant	2025	https://conductscience.org/library/papers/40881764	PubMed
40,428,118	Assessing Implantation Sites for Pancreatic Islet Cell Transplantation: Implications for Type 1 Diabetes Mellitus Treatment.	Bioengineering (Basel)	2025	https://conductscience.org/library/papers/40428118	PubMed
40,204,281	Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy.	Am J Physiol Cell Physiol	2025	https://conductscience.org/library/papers/40204281	PubMed
34,319,573	Total pancreatectomy sequelae and quality of life: results of islet autotransplantation as a possible mitigation strategy.	Updates Surg	2021	https://conductscience.org/library/papers/34319573	PubMed
34,193,595	New Aspects of Diabetes Research and Therapeutic Development.	Pharmacol Rev	2021	https://conductscience.org/library/papers/34193595	PubMed
30,705,364	Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation.	Sci Rep	2019	https://conductscience.org/library/papers/30705364	PubMed
29,202,467	Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection.	J Clin Invest	2018	https://conductscience.org/library/papers/29202467	PubMed
28,702,240	Brief review: cell replacement therapies to treat type 1 diabetes mellitus.	Clin Diabetes Endocrinol	2016	https://conductscience.org/library/papers/28702240	PubMed
28,069,642	α-1 Antitrypsin Enhances Islet Engraftment by Suppression of Instant Blood-Mediated Inflammatory Reaction.	Diabetes	2017	https://conductscience.org/library/papers/28069642	PubMed
25,679,812	The co-transplantation of bone marrow derived mesenchymal stem cells reduced inflammation in intramuscular islet transplantation.	PLoS One	2015	https://conductscience.org/library/papers/25679812	PubMed
25,389,531	Nonhuman primate models of type 1 diabetes mellitus for islet transplantation.	J Diabetes Res	2014	https://conductscience.org/library/papers/25389531	PubMed
25,146,295	Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.	Science	2014	https://conductscience.org/library/papers/25146295	PubMed
24,297,649	Chronic pancreatitis and primary sclerosing cholangitis--first report of intrahepatic autologous islet transplantation.	J Gastrointest Surg	2014	https://conductscience.org/library/papers/24297649	PubMed
23,346,100	Animal models of diabetes mellitus for islet transplantation.	Exp Diabetes Res	2012	https://conductscience.org/library/papers/23346100	PubMed
22,990,986	Wearable and implantable pancreas substitutes.	J Artif Organs	2013	https://conductscience.org/library/papers/22990986	PubMed
22,461,742	Islet transplantation in type I diabetes mellitus.	Yale J Biol Med	2012	https://conductscience.org/library/papers/22461742	PubMed
22,235,361	Advances and challenges in islet transplantation: islet procurement rates and lessons learned from suboptimal islet transplantation.	J Transplant	2011	https://conductscience.org/library/papers/22235361	PubMed
21,099,316	The isolated pancreatic islet as a micro-organ and its transplantation to cure diabetes: celebrating the legacy of Paul Lacy.	Islets	2010	https://conductscience.org/library/papers/21099316	PubMed

Show 14 more cited byShow fewer cited bySee all 44 cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

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Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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