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Paper · 42092003

Engineering challenges and translational opportunities in emerging gene delivery platforms.

Ma Y and 6 others. Nat Biomed Eng, 2026. Cited by 19 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Engineering challenges and translational opportunities in emerging gene delivery platforms. Papers, record 42092003. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42092003

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Engineering challenges and translational opportunities in emerging gene delivery platforms.
PubMed
Journal
Nat Biomed Eng
PubMed
Year
2026
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
19
iCite
Relative citation ratio, by iCite
11.74, provisional
iCite
Revised in PubMed
2026-06-18
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ma YYifanhttps://orcid.org/0000-0002-9371-4365
2Dong SShiyanhttps://orcid.org/0000-0003-2912-8895
3Wu AAnnettehttps://orcid.org/0009-0005-8343-4748
4Jeong SDSeong Donghttps://orcid.org/0009-0003-5163-3924
5Lee ASAndrew S
6Jiang WWenhttps://orcid.org/0000-0001-9154-633X
7Kim BYSBetty Y Shttps://orcid.org/0000-0001-6890-8355

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Gene Transfer TechniquesMajor topic
Genetic TherapyMajor topic
Humans
Animals
Genetic Vectors
Nanoparticles
Dependovirus
Translational Research, Biomedical
Lipids
Extracellular Vesicles

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References264

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
129,326,244Gene therapy comes of age.Science2018https://conductscience.org/library/papers/29326244PubMed
238,006,899A new age of precision gene therapy.Lancet2024https://conductscience.org/library/papers/38006899PubMed
333,277,608Engineering precision nanoparticles for drug delivery.Nat Rev Drug Discov2021https://conductscience.org/library/papers/33277608PubMed
440,022,444Gene therapy then and now: A look back at changes in the field over the past 25 years.Mol Ther2025https://conductscience.org/library/papers/40022444PubMed
533,495,615The clinical landscape for AAV gene therapies.Nat Rev Drug Discov2021https://conductscience.org/library/papers/33495615PubMed
633,558,455Viral vector platforms within the gene therapy landscape.Signal Transduct Target Ther2021https://conductscience.org/library/papers/33558455PubMed
734,211,166Extracellular vesicles as a next-generation drug delivery platform.Nat Nanotechnol2021https://conductscience.org/library/papers/34211166PubMed
835,236,964Therapeutically harnessing extracellular vesicles.Nat Rev Drug Discov2022https://conductscience.org/library/papers/35236964PubMed
941,104,040Extracellular vesicles for the delivery of gene therapy.Nat Rev Bioeng2025https://conductscience.org/library/papers/41104040PubMed
1023,023,051Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union.Mol Ther2012https://conductscience.org/library/papers/23023051PubMed

1 to 10 of 264

See all 264 references

Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 19 citations.

PMIDTitleJournalYearIn PapersSource
42,942,051A 3D-Printed BCP/PLGA-PEG-PLGA Scaffold for LNC000133-Loaded BMSC-Derived Exosome Delivery Promotes Repair of Steroid-Induced Osteonecrosis of the Femoral Head.Int J Mol Sci2026https://conductscience.org/library/papers/42942051PubMed
42,941,803Enhancing Exosome Production from Adipose-Derived Stem Cells via Arachidonic Acid Priming for Diabetic Wound Healing.Int J Mol Sci2026https://conductscience.org/library/papers/42941803PubMed
42,884,980Hydrogel-Based BMP-2 Delivery for Bone Regeneration: From Material Control to Biological and Translational Evaluation.Polymers (Basel)2026https://conductscience.org/library/papers/42884980PubMed
42,883,409Extracellular Vesicles in Neonatology: Have We Found the Magic Bullet?Biology (Basel)2026https://conductscience.org/library/papers/42883409PubMed
42,797,269Recent Advances in Non-Viral Vectors for Gene Therapy and Gene Delivery: From Lipid Nanoparticles to Engineered Extracellular Vesicles.Pharmaceutics2026https://conductscience.org/library/papers/42797269PubMed
42,794,630Reprogramming the Aging Type H Vascular Niche via Myeloid Angiogenic Cell-Derived Extracellular Vesicles: Mechanisms, Engineering Strategies, and Translational Perspectives.Int J Mol Sci2026https://conductscience.org/library/papers/42794630PubMed
42,791,958Extracellular Vesicles and Their Role in Osteogenesis.Bioengineering (Basel)2026https://conductscience.org/library/papers/42791958PubMed
42,791,896Electrical Stimulation of Human Adipose Tissue-Derived Mesenchymal Stem Cells and Schwann Cells for Regulating Extracellular Vesicle Biogenesis and Inflammation.Bioengineering (Basel)2026https://conductscience.org/library/papers/42791896PubMed
42,783,392Extracellular Vesicles at the Interface of Cancer Therapy and Regenerative Medicine: Biology, Bidirectional Roles, and Engineered Therapeutics.Med Sci (Basel)2026https://conductscience.org/library/papers/42783392PubMed
42,719,520Exploring the role of CRISPR in advancing space biotechnology: challenges and solutions for human survival beyond earth.Front Bioeng Biotechnol2026https://conductscience.org/library/papers/42719520PubMed

1 to 10 of 27

See all 27 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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