Paper · 42829918

WFS1 Deficiency Impairs PIAS4-Associated SUMOylation and Increases Ubiquitin-Mediated Spermatogenesis-Related Protein Degradation Leading to Testicular Male Infertility.

Tian Y and 14 others. Adv Sci (Weinh), 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. WFS1 Deficiency Impairs PIAS4-Associated SUMOylation and Increases Ubiquitin-Mediated Spermatogenesis-Related Protein Degradation Leading to Testicular Male Infertility. Papers, record 42829918. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42829918

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Paper

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Title: WFS1 Deficiency Impairs PIAS4-Associated SUMOylation and Increases Ubiquitin-Mediated Spermatogenesis-Related Protein Degradation Leading to Testicular Male Infertility.
Journal: Adv Sci (Weinh)
Year: 2026
Publication types: Journal Article
PubMed: https://pubmed.ncbi.nlm.nih.gov/42829918/
DOI: https://doi.org/10.1002/advs.78060
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13634479/
The journal: https://conductscience.org/library/journal-index/101664569
Revised in PubMed: 2026-10-06

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Authors15

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Tian Y	Yunchuan	https://orcid.org/0009-0008-3431-1137
2	Zhao G	Guicheng
3	Wang X	Xiang	https://orcid.org/0000-0002-8930-6801
4	Tang X	Xinyao
5	Shen G	Gan
6	Ruan T	Tiechao	https://orcid.org/0000-0002-2924-0230
7	Jiang C	Chuan
8	Zhao S	Shikun
9	Zhang J	Jincheng
10	Cui X	Xinyue

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Topics0

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Grants1

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Grant, as the record writes it	Agency	Country	NIH project	Stated by
82471650	National Natural Science Foundation of China			PubMed

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Trials0

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None in this release.

Comments and corrections0

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References64

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	25,019,163	Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies.	PLoS One	2014	https://conductscience.org/library/papers/25019163	PubMed
2	3,086,928	Wolfram (DIDMOAD) syndrome: a complex long-term problem in management.	Q J Med	1986	https://conductscience.org/library/papers/3086928	PubMed
3	30,080,443	A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging.	FASEB J	2019	https://conductscience.org/library/papers/30080443	PubMed
4	27,012,465	Ubiquitin modifications.	Cell Res	2016	https://conductscience.org/library/papers/27012465	PubMed
5	35,037,020	GPS-Uber: a hybrid-learning framework for prediction of general and E3-specific lysine ubiquitination sites.	Brief Bioinform	2022	https://conductscience.org/library/papers/35037020	PubMed
6	33,637,650	Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.	Proc Natl Acad Sci U S A	2021	https://conductscience.org/library/papers/33637650	PubMed
7	38,709,873	GPS-SUMO 2.0: an updated online service for the prediction of SUMOylation sites and SUMO-interacting motifs.	Nucleic Acids Res	2024	https://conductscience.org/library/papers/38709873	PubMed
8	26,994,494	New insights into the role of the Brdt protein in the regulation of development and spermatogenesis in the mouse.	Gene Expr Patterns	2016	https://conductscience.org/library/papers/26994494	PubMed
9	31,658,956	High Prevalence of a Monogenic Cause in Han Chinese Diagnosed With Type 1 Diabetes, Partly Driven by Nonsyndromic Recessive WFS1 Mutations.	Diabetes	2020	https://conductscience.org/library/papers/31658956	PubMed
10	29,891,922	SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity.	Nat Commun	2018	https://conductscience.org/library/papers/29891922	PubMed

1 to 10 of 64

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Cited by0

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Genes0

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Drugs0

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Data0

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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