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Paper · 42850682

Mechanism-Informed Language Modeling and Oxygenated 3D Screening Identify Berberine-Enzalutamide Synergy in Prostate Cancer Models.

Lo CH and 15 others. Adv Sci (Weinh), 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mechanism-Informed Language Modeling and Oxygenated 3D Screening Identify Berberine-Enzalutamide Synergy in Prostate Cancer Models. Papers, record 42850682. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42850682

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Mechanism-Informed Language Modeling and Oxygenated 3D Screening Identify Berberine-Enzalutamide Synergy in Prostate Cancer Models.
Journal
Adv Sci (Weinh)
Year
2026
Publication types
Journal Article
Revised in PubMed
2026-10-13

Source PubMed

Authors16

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Lo CHChih-Huihttps://orcid.org/0000-0002-3759-5330
2Shi KKatiehttps://orcid.org/0009-0002-9412-9878
3Kafadarian LLinahttps://orcid.org/0009-0008-1269-4501
4Bermudez AAlexandra
5Diaz JJohnny
6Edwards LLiamhttps://orcid.org/0009-0003-2352-9636
7Hong YYunqi
8Chen ZZiyihttps://orcid.org/0009-0008-7220-7875
9Hwang HHyeonjihttps://orcid.org/0009-0008-7185-9345
10Yan WWeihong

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Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants20

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
HT9425-25-1-0290U.S. Department of DefensePubMedPubMed
R37CA240822NCI NIH HHSUnited StatesR37CA240822PubMedNIH RePORTER
R01 CA274978NCI NIH HHSUnited StatesR01CA274978PubMedNIH RePORTER
20245682Neuroendocrine Tumor Research FoundationPubMedPubMed
Mike Slive Foundation for Prostate Cancer ResearchPubMedPubMed
R01CA287669NCI NIH HHSUnited StatesR01CA287669PubMedNIH RePORTER
HT9425-24-1-0396U.S. Department of DefensePubMedPubMed
R01 CA287669NCI NIH HHSUnited StatesR01CA287669PubMedNIH RePORTER
R01CA274978NCI NIH HHSUnited StatesR01CA274978PubMedNIH RePORTER
DBI-2325121National Science FoundationPubMedPubMed

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Update of41,659,618Mechanistic Language Modeling and Oxygenated 3D Screening Reveal Berberine and Enzalutamide Synergy in Resistant Prostate Cancer.https://conductscience.org/library/papers/41659618

Source PubMed

References61

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
118,264,981Energy metabolism transition in multi-cellular human tumor spheroids.J Cell Physiol2008https://conductscience.org/library/papers/18264981PubMed
237,852,959miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication.Cell Death Dis2023https://conductscience.org/library/papers/37852959PubMed
318,008,377Androgen signaling and its interactions with other signaling pathways in prostate cancer.Bioessays2007https://conductscience.org/library/papers/18008377PubMed
434,571,537DeepDDS: deep graph neural network with attention mechanism to predict synergistic drug combinations.Brief Bioinform2022https://conductscience.org/library/papers/34571537PubMed
526,378,018Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells.Oncotarget2015https://conductscience.org/library/papers/26378018PubMed
636,321,951Emulsification by vitamin E TPGS or Quillaja extract enhanced absorption of berberine without affecting its metabolism in humans.Food Funct2022https://conductscience.org/library/papers/36321951PubMed
725,649,766Intracrine Androgens and AKR1C3 Activation Confer Resistance to Enzalutamide in Prostate Cancer.Cancer Res2015https://conductscience.org/library/papers/25649766PubMed
833,663,530Challenges of applying multicellular tumor spheroids in preclinical phase.Cancer Cell Int2021https://conductscience.org/library/papers/33663530PubMed
939,221,997DTI-LM: language model powered drug-target interaction prediction.Bioinformatics2024https://conductscience.org/library/papers/39221997PubMed
1040,240,608Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation.Nature2025https://conductscience.org/library/papers/40240608PubMed

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first.

None in this release.

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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