Paper · 42879477

Global proteolysis during starvation governs proteome remodeling and a survival-regrowth trade-off in bacteria.

Manzanarez G and 11 others. Proc Natl Acad Sci U S A, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Global proteolysis during starvation governs proteome remodeling and a survival-regrowth trade-off in bacteria. Papers, record 42879477. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42879477

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Global proteolysis during starvation governs proteome remodeling and a survival-regrowth trade-off in bacteria.
Journal: Proc Natl Acad Sci U S A
Year: 2026
Publication types: Journal Article
PubMed: https://pubmed.ncbi.nlm.nih.gov/42879477/
DOI: https://doi.org/10.1073/pnas.2611560123
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13684143/
The journal: https://conductscience.org/library/journal-index/7505876
Revised in PubMed: 2026-10-23

Source PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Manzanarez G	Gabriel
2	Balakrishnan R	Rohan
3	Kannan H	Harish	https://orcid.org/0009-0001-3908-0584
4	Abele M	Miriam
5	Okano H	Hiroyuki
6	She F	Fukang
7	Zhang Z	Zhongge
8	Wu C	Chenhao
9	Freiman L	Lance
10	Ludwig C	Christina	https://orcid.org/0000-0002-6131-7322

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Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Proteome	Major topic
Proteolysis	Major topic
Escherichia coli	Major topic
Escherichia coli Proteins	Major topic
Sigma Factor
Bacterial Proteins
Carbon
Amino Acids
Gene Expression Regulation, Bacterial

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	NIH project	Stated by	Source
R35GM152133	HHS \| NIH \| National Institute of General Medical Sciences (NIGMS)	R35GM152133	PubMed	NIH RePORTER
542387	Simons Foundation (SF)		PubMed	PubMed
823839	European Proteomics Infrastructure Consortium providing access (EPIC-XS)		PubMed	PubMed
INST 95/1435-1 FUGG	German Research Foundation		PubMed	PubMed
graduate fellowship	DOW \| National Defense Science and Engineering Graduate (NDSEG)		PubMed	PubMed
2023-1	Bayerisch-Kalifornischen Hochschulzentrum (BaCaTeC)		PubMed	PubMed
2545232	National Science Foundation (NSF)		PubMed	PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References108

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	24,366,340	Historical landmarks of autophagy research.	Cell Res	2014	https://conductscience.org/library/papers/24366340	PubMed
2	39,003,262	Global protein turnover quantification in Escherichia coli reveals cytoplasmic recycling under nitrogen limitation.	Nat Commun	2024	https://conductscience.org/library/papers/39003262	PubMed
3	12,657,059	Global gene expression in Escherichia coli biofilms.	Mol Microbiol	2003	https://conductscience.org/library/papers/12657059	PubMed
4	36,737,588	Enzyme expression kinetics by Escherichia coli during transition from rich to minimal media depends on proteome reserves.	Nat Microbiol	2023	https://conductscience.org/library/papers/36737588	PubMed
5	37,770,697	Sentinel cells programmed to respond to environmental DNA including human sequences.	Nat Chem Biol	2024	https://conductscience.org/library/papers/37770697	PubMed
6	12,941,949	Degradation of stable RNA in bacteria.	J Biol Chem	2003	https://conductscience.org/library/papers/12941949	PubMed
7	3,536,847	Starvation proteins in Escherichia coli: kinetics of synthesis and role in starvation survival.	J Bacteriol	1986	https://conductscience.org/library/papers/3536847	PubMed
8	36,480,614	Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria.	Science	2022	https://conductscience.org/library/papers/36480614	PubMed
9	31,578,326	Systematic identification of metabolites controlling gene expression in E. coli.	Nat Commun	2019	https://conductscience.org/library/papers/31578326	PubMed
10	2,661,527	Accumulation of 3-(N-morpholino)propanesulfonate by osmotically stressed Escherichia coli K-12.	J Bacteriol	1989	https://conductscience.org/library/papers/2661527	PubMed

1 to 10 of 108

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first.

None in this release.

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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