Paper · 42882467

Changes in Core Temperature Following Administration of FC5, a Blood-Brain Carrier Fused with Neurotensin in Mice, Rats and Non-Human Primates.

Yogi A and 8 others. Cells, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Changes in Core Temperature Following Administration of FC5, a Blood-Brain Carrier Fused with Neurotensin in Mice, Rats and Non-Human Primates. Papers, record 42882467. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42882467

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Changes in Core Temperature Following Administration of FC5, a Blood-Brain Carrier Fused with Neurotensin in Mice, Rats and Non-Human Primates.
Journal: Cells
Year: 2026
Publication types: Journal Article
PubMed: https://pubmed.ncbi.nlm.nih.gov/42882467/
DOI: https://doi.org/10.3390/cells15191770
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13664285/
The journal: https://conductscience.org/library/journal-index/101600052
Revised in PubMed: 2026-10-20

Source PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Yogi A	Alvaro
2	Lessard E	Etienne
3	Brunette E	Eric
4	Delaney CE	Christie E	https://orcid.org/0009-0005-6958-1725
5	Haqqani AS	Arsalan S	https://orcid.org/0000-0003-2454-8989
6	Robotham A	Anna	https://orcid.org/0000-0002-6464-736X
7	Alata W	Wael
8	Moreno MJ	Maria J
9	Stanimirovic DB	Danica B

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Neurotensin	Major topic
Blood-Brain Barrier	Major topic
Recombinant Fusion Proteins	Major topic
Immunoglobulin Fc Fragments	Major topic
Body Temperature	Major topic
Animals
Humans
Rats
Mice
Receptors, Neurotensin
Male
Transcytosis

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References52

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	33,493,670	C-terminal lysine clipping of IgG1: impact on binding to human FcγRIIIa and neonatal Fc receptors.	Eur J Pharm Sci	2021	https://conductscience.org/library/papers/33493670	PubMed
2	15,680,187	Antinociceptive, hypothermic, hypotensive, and reinforcing effects of a novel neurotensin receptor agonist, NT69L, in rhesus monkeys.	Pharmacol Biochem Behav	2005	https://conductscience.org/library/papers/15680187	PubMed
3	8,872,532	New hydroxamate inhibitors of neurotensin-degrading enzymes. Synthesis and enzyme active-site recognition.	Int J Pept Protein Res	1996	https://conductscience.org/library/papers/8872532	PubMed
4	30,226,787	Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor.	Mol Pharm	2018	https://conductscience.org/library/papers/30226787	PubMed
5	11,772,942	Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium.	FASEB J	2002	https://conductscience.org/library/papers/11772942	PubMed
6	26,979,921	The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes.	Neuropharmacology	2017	https://conductscience.org/library/papers/26979921	PubMed
7	26,839,377	Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1.	FASEB J	2016	https://conductscience.org/library/papers/26839377	PubMed
8	34,974,334	Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse.	Drug Metab Pharmacokinet	2022	https://conductscience.org/library/papers/34974334	PubMed
9	29,485,883	Enhanced Delivery of Galanin Conjugates to the Brain through Bioengineering of the Anti-Transferrin Receptor Antibody OX26.	Mol Pharm	2018	https://conductscience.org/library/papers/29485883	PubMed
10	7,667,183	Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate.	Pharm Res	1995	https://conductscience.org/library/papers/7667183	PubMed

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Cited by0

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None in this release.

Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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