Paper · 42886804

MFN2-associated astrocyte dysfunction contributes to neuronal hyperexcitability and depressive-like behaviors.

Ma FX and 10 others. Sci Adv, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. MFN2-associated astrocyte dysfunction contributes to neuronal hyperexcitability and depressive-like behaviors. Papers, record 42886804. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42886804

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Paper

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Title: MFN2-associated astrocyte dysfunction contributes to neuronal hyperexcitability and depressive-like behaviors.
Journal: Sci Adv
Year: 2026
Publication types: Journal Article
PubMed: https://pubmed.ncbi.nlm.nih.gov/42886804/
DOI: https://doi.org/10.1126/sciadv.aed8795
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13674505/
The journal: https://conductscience.org/library/journal-index/101653440
Revised in PubMed: 2026-10-20

Source PubMed

Authors11

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Ma FX	Feng-Xia	https://orcid.org/0009-0001-0395-0568
2	Wang M	Min
3	Fang SY	Shuo-Yan
4	Wang XX	Xiao-Xin
5	Xu SH	Shen-Han
6	Zhao XX	Xin-Xin
7	Liu YX	Yu-Xiao
8	Wang C	Cong
9	Qiao C	Chen	https://orcid.org/0000-0003-4315-0351
10	Wang QL	Qiu-Ling	https://orcid.org/0009-0005-5813-9368

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Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Astrocytes	Major topic
GTP Phosphohydrolases	Major topic
Neurons	Major topic
Depression	Major topic
Major Depressive Disorder	Major topic
Animals
Mice
Humans
Mitochondria
Male
Hippocampus
Mitophagy
Disease Models, Animal
STAT1 Transcription Factor
Mitochondrial Dynamics
Mitochondrial Proteins

Source PubMed

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None in this release.

Trials0

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None in this release.

Comments and corrections0

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References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	37,985,735	Mitochondrial fission drives neuronal metabolic burden to promote stress susceptibility in male mice.	Nat Metab	2023	https://conductscience.org/library/papers/37985735	PubMed
2	34,650,203	Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: Does inflammation play a role?	Mol Psychiatry	2022	https://conductscience.org/library/papers/34650203	PubMed
3	33,583,561	Mitofusin-2 in the Nucleus Accumbens Regulates Anxiety and Depression-like Behaviors Through Mitochondrial and Neuronal Actions.	Biol Psychiatry	2021	https://conductscience.org/library/papers/33583561	PubMed
4	39,888,279	Microglia-Derived Interleukin-6 Triggers Astrocyte Apoptosis in the Hippocampus and Mediates Depression-Like Behavior.	Adv Sci (Weinh)	2025	https://conductscience.org/library/papers/39888279	PubMed
5	39,495,924	The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release.	Proc Natl Acad Sci U S A	2024	https://conductscience.org/library/papers/39495924	PubMed
6	33,734,498	Implication of cerebral astrocytes in major depression: A review of fine neuroanatomical evidence in humans.	Glia	2021	https://conductscience.org/library/papers/33734498	PubMed
7	31,362,874	Anxiety and Brain Mitochondria: A Bidirectional Crosstalk.	Trends Neurosci	2019	https://conductscience.org/library/papers/31362874	PubMed
8	28,317,185	An astroglial basis of major depressive disorder? An overview.	Glia	2017	https://conductscience.org/library/papers/28317185	PubMed
9	38,331,979	Major depressive disorder: hypothesis, mechanism, prevention and treatment.	Signal Transduct Target Ther	2024	https://conductscience.org/library/papers/38331979	PubMed
10	39,084,500	An Astroglial Basis of Major Depressive Disorder: Molecular, Cellular, and Circuit Features.	Biol Psychiatry	2025	https://conductscience.org/library/papers/39084500	PubMed

1 to 10 of 35

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Cited by0

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Genes0

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None in this release.

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None in this release.

Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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