Paper · 4290076

Inhibition of adrenal corticosteroid synthesis by aminoglutethimide: studies of the mechanism of action.

Dexter RN and 3 others. J Clin Endocrinol Metab, 1967. Cited by 341 papers, by iCite.

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ConductScience Library. Inhibition of adrenal corticosteroid synthesis by aminoglutethimide: studies of the mechanism of action. Papers, record 4290076. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4290076

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Inhibition of adrenal corticosteroid synthesis by aminoglutethimide: studies of the mechanism of action.; PubMed
Journal: J Clin Endocrinol Metab; PubMed
Year: 1967; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/4290076/; PubMed
DOI: https://doi.org/10.1210/jcem-27-4-473; PubMed
The journal: https://conductscience.org/library/journal-index/0375362; PubMed
Citations, by iCite: 341; iCite
Revised in PubMed: 2014-11-20; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Dexter RN	R N
2	Fishman LM	L M
3	Ney RL	R L
4	Liddle GW	G W

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adrenal Glands	Major topic
Corticosterone	Major topic
Enzymes	Major topic
Adrenal Cortex Hormones
Adrenocorticotropic Hormone
Aminoglutethimide
Animals
Anticonvulsants
Cholesterol
Hypophysectomy
In Vitro Techniques
Male
Pituitary Gland
Pregnenolone
Protein Biosynthesis
Rats
Secretory Rate

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by49

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 341 citations.

PMID	Title	Journal	Year	In Papers	Source
30,775,248	Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer.	Asian J Urol	2019	https://conductscience.org/library/papers/30775248	PubMed
28,522,880	Immunolocalization of Glutathione-Peroxidase (GPx1) in the Rat Adrenal Cortex: Correlation between Steroidogenesis and Lipid Peroxidation.	Acta Histochem Cytochem	2017	https://conductscience.org/library/papers/28522880	PubMed
26,689,671	Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.	J Med Chem	2016	https://conductscience.org/library/papers/26689671	PubMed
24,948,872	Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment.	Int J Biol Sci	2014	https://conductscience.org/library/papers/24948872	PubMed
23,870,673	The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis.	J Allergy Clin Immunol	2013	https://conductscience.org/library/papers/23870673	PubMed
21,330,403	Reactive oxygen species (ROS) play a critical role in the cAMP-induced activation of Ras and the phosphorylation of ERK1/2 in Leydig cells.	Mol Endocrinol	2011	https://conductscience.org/library/papers/21330403	PubMed
17,973,095	Aromatase inhibitors: past, present and future in breast cancer therapy.	Med Oncol	2008	https://conductscience.org/library/papers/17973095	PubMed
16,552,601	Relationship between steroidogenesis and spermiation in Rana catesbeiana and Leptodactylus ocellatus.	J Comp Physiol B	2006	https://conductscience.org/library/papers/16552601	PubMed
11,572,330	Cold-induced increment in rat adrenal gland type II deiodinase is corticosterone dependent.	Endocrine	2001	https://conductscience.org/library/papers/11572330	PubMed
8,076,220	Modulation of adrenal cell functions by cadmium salts: 2. Sites affected by CdCl2 during unstimulated steroid synthesis.	Cell Biol Toxicol	1994	https://conductscience.org/library/papers/8076220	PubMed

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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