Paper · 42903166

TREM2+ macrophages mediate anticancer therapy-induced immune evasion in lung adenocarcinoma via the CCL5/CCL22-Treg axis.

Kim CY and 3 others. Front Immunol, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. TREM2+ macrophages mediate anticancer therapy-induced immune evasion in lung adenocarcinoma via the CCL5/CCL22-Treg axis. Papers, record 42903166. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42903166

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: TREM2+ macrophages mediate anticancer therapy-induced immune evasion in lung adenocarcinoma via the CCL5/CCL22-Treg axis.
Journal: Front Immunol
Year: 2026
Publication types: Journal Article, Research Support, Non-U.S. Gov't
PubMed: https://pubmed.ncbi.nlm.nih.gov/42903166/
DOI: https://doi.org/10.3389/fimmu.2026.1914462
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13680435/
The journal: https://conductscience.org/library/journal-index/101560960
Revised in PubMed: 2026-10-27

Source PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Kim CY	Chi Young
2	Cha YJ	Yoon Jin
3	Park MK	Min Kyung
4	Chang YS	Yoon Soo

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Lung Neoplasms	Major topic
Adenocarcinoma of Lung	Major topic
T-Lymphocytes, Regulatory	Major topic
Membrane Glycoproteins	Major topic
Receptors, Immunologic	Major topic
Tumor-Associated Macrophages	Major topic
Macrophages	Major topic
Animals
Chemokine CCL22
Humans
Mice
Chemokine CCL5
Tumor Microenvironment
Signal Transduction
Antineoplastic Agents
Mice, Inbred C57BL
Female

Source PubMed

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Comments and corrections0

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References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	34,800,916	Early lung carcinogenesis and tumor microenvironment observed by single-cell transcriptome analysis.	Transl Oncol	2022	https://conductscience.org/library/papers/34800916	PubMed
2	40,992,762	Acidic Tumor Microenvironments and Emerging Therapeutic Strategies for Cancer Therapy.	Yonsei Med J	2025	https://conductscience.org/library/papers/40992762	PubMed
3	30,910,796	CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes.	J Exp Med	2019	https://conductscience.org/library/papers/30910796	PubMed
4	40,850,976	Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments.	Signal Transduct Target Ther	2025	https://conductscience.org/library/papers/40850976	PubMed
5	31,751,012	Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC.	N Engl J Med	2020	https://conductscience.org/library/papers/31751012	PubMed
6	18,287,226	NF-kappaB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86.	J Virol	2008	https://conductscience.org/library/papers/18287226	PubMed
7	33,837,297	Systemic immunity in cancer.	Nat Rev Cancer	2021	https://conductscience.org/library/papers/33837297	PubMed
8	20,467,426	The SYK tyrosine kinase: a crucial player in diverse biological functions.	Nat Rev Immunol	2010	https://conductscience.org/library/papers/20467426	PubMed
9	32,425,930	Inducers, Attractors and Modulators of CD4+ Treg Cells in Non-Small-Cell Lung Cancer.	Front Immunol	2020	https://conductscience.org/library/papers/32425930	PubMed
10	30,979,687	Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species.	Immunity	2019	https://conductscience.org/library/papers/30979687	PubMed

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Cited by0

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Genes0

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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