Paper · 42929068

Sequence space exploration in SHP2: mechanistic insights from disease-associated mutations.

van Vlimmeren AE and 3 others. Biochem J, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Sequence space exploration in SHP2: mechanistic insights from disease-associated mutations. Papers, record 42929068. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42929068

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Sequence space exploration in SHP2: mechanistic insights from disease-associated mutations.
Journal: Biochem J
Year: 2026
Publication types: Journal Article, Review
PubMed: https://pubmed.ncbi.nlm.nih.gov/42929068/
DOI: https://doi.org/10.1042/bcj20250266
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13714419/
The journal: https://conductscience.org/library/journal-index/2984726R
Revised in PubMed: 2026-11-02

Source PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	van Vlimmeren AE	Anne E	https://orcid.org/0000-0003-0379-4945
2	Jiang Z	Ziyuan	https://orcid.org/0009-0003-6035-4126
3	Semoy DA	Devon A	https://orcid.org/0009-0006-7957-0277
4	Shah NH	Neel H	https://orcid.org/0000-0002-1186-0626

Source PubMed

Topics6

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Protein Tyrosine Phosphatase, Non-Receptor Type 11	Major topic
Mutation	Major topic
Humans
Signal Transduction
Animals
Protein Conformation

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R35 GM138014	NIGMS NIH HHS	United States	R35GM138014	PubMed	NIH RePORTER
RSG-23-1038049-01-TBE	American Cancer Society (ACS)			PubMed	PubMed
R35GM138014	HHS \| NIH \| National Institute of General Medical Sciences (NIGMS)		R35GM138014	PubMed	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References147

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	32,248,557	Autosomal dominant hyper IgE syndrome from a single centre in Chongqing, China (2009-2018).	Scand J Immunol	2020	https://conductscience.org/library/papers/32248557	PubMed
2	41,867,803	Cancer-Causing Mutations Alter the Interplay Between Loop Dynamics and Catalysis in the Protein Tyrosine Phosphatases SHP-1 and SHP-2.	bioRxiv	2026	https://conductscience.org/library/papers/41867803	PubMed
3	16,474,405	Germline KRAS mutations cause Noonan syndrome.	Nat Genet	2006	https://conductscience.org/library/papers/16474405	PubMed
4	41,225,768	The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2.	Protein Sci	2025	https://conductscience.org/library/papers/41225768	PubMed
5	24,825,865	Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia.	Blood	2014	https://conductscience.org/library/papers/24825865	PubMed
6	40,638,710	Scalable emulation of protein equilibrium ensembles with generative deep learning.	Science	2025	https://conductscience.org/library/papers/40638710	PubMed
7	26,889,708	The Role of Protein Loops and Linkers in Conformational Dynamics and Allostery.	Chem Rev	2016	https://conductscience.org/library/papers/26889708	PubMed
8	23,584,145	Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia.	J Proteomics	2013	https://conductscience.org/library/papers/23584145	PubMed
9	17,157,040	SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.	Immunity	2006	https://conductscience.org/library/papers/17157040	PubMed
10	35,231,400	Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state.	Mol Cell	2022	https://conductscience.org/library/papers/35231400	PubMed

1 to 10 of 147

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Cited by0

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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