Paper · 42939775
ERK5 Signaling and Ferroptosis in Bone Homeostasis: Emerging Connections and Therapeutic Perspectives.
Zhang J and 6 others. Biomolecules, 2026.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. ERK5 Signaling and Ferroptosis in Bone Homeostasis: Emerging Connections and Therapeutic Perspectives. Papers, record 42939775. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42939775
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- ERK5 Signaling and Ferroptosis in Bone Homeostasis: Emerging Connections and Therapeutic Perspectives.
- Journal
- Biomolecules
- Year
- 2026
- Publication types
- Journal Article, Review
- Revised in PubMed
- 2026-10-28
Source PubMed
Topics8
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Ferroptosis | Major topic |
| Homeostasis | Major topic |
| Mitogen-Activated Protein Kinase 7 | Major topic |
| Bone and Bones | Major topic |
| Humans | |
| Animals | |
| Signal Transduction | |
| Osteocytes |
Source PubMed
Grants1
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by |
|---|---|---|---|---|
| 82360436 | National Natural Science Foundation of China | PubMed |
Source PubMed
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References121
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 25,383,517 | Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. | Nature | 2014 | https://conductscience.org/library/papers/25383517 | PubMed |
| 2 | 35,752,374 | Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation. | Free Radic Biol Med | 2022 | https://conductscience.org/library/papers/35752374 | PubMed |
| 3 | 22,886,088 | Targeted deletion of Sost distal enhancer increases bone formation and bone mass. | Proc Natl Acad Sci U S A | 2012 | https://conductscience.org/library/papers/22886088 | PubMed |
| 4 | 15,548,525 | The unique C-terminal tail of the mitogen-activated protein kinase ERK5 regulates its activation and nuclear shuttling. | J Biol Chem | 2005 | https://conductscience.org/library/papers/15548525 | PubMed |
| 5 | 12,748,652 | Osteoclast differentiation and activation. | Nature | 2003 | https://conductscience.org/library/papers/12748652 | PubMed |
| 6 | 30,563,338 | Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. | J Med Chem | 2019 | https://conductscience.org/library/papers/30563338 | PubMed |
| 7 | 41,751,200 | The Interplay Between Bone Biology and Iron Metabolism: Molecular Mechanisms and Clinical Implications. | Biomedicines | 2026 | https://conductscience.org/library/papers/41751200 | PubMed |
| 8 | 36,364,768 | Ferroptosis of Endothelial Cells in Vascular Diseases. | Nutrients | 2022 | https://conductscience.org/library/papers/36364768 | PubMed |
| 9 | 31,914,120 | Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway. | Med Sci Monit | 2020 | https://conductscience.org/library/papers/31914120 | PubMed |
| 10 | 38,366,038 | The cell biology of ferroptosis. | Nat Rev Mol Cell Biol | 2024 | https://conductscience.org/library/papers/38366038 | PubMed |
1 to 10 of 121
See all 121 referencesCited by0
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None in this release.
Genes0
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
None in this release.
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
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None in this release.
Data dates
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- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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