Paper · 42962034

Evidence of active whole-genome doubling (WGD) subclones in non-WGD tumors.

He F and 5 others. Sci Adv, 2026.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Evidence of active whole-genome doubling (WGD) subclones in non-WGD tumors. Papers, record 42962034. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42962034

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Evidence of active whole-genome doubling (WGD) subclones in non-WGD tumors.
Journal: Sci Adv
Year: 2026
Publication types: Journal Article
PubMed: https://pubmed.ncbi.nlm.nih.gov/42962034/
DOI: https://doi.org/10.1126/sciadv.aee7939
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13722003/
The journal: https://conductscience.org/library/journal-index/101653440
Revised in PubMed: 2026-11-01

Source PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	He F	Funan	https://orcid.org/0000-0002-4592-4034
2	Noureen M	Mehwish
3	Dray E	Eloise	https://orcid.org/0000-0001-6793-9838
4	Ignatius MS	Myron S	https://orcid.org/0000-0001-6639-7707
5	Wang X	Xiaojing	https://orcid.org/0000-0002-2631-4708
6	Zheng S	Siyuan	https://orcid.org/0000-0002-1031-9424

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Neoplasms	Major topic
Genome, Human	Major topic
Humans
Mutation
DNA Copy Number Variations
Single-Cell Analysis
Gene Expression Regulation, Neoplastic
Tumor Suppressor Protein p53
Chromosomal Instability
Genomics

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R21 ES035997	NIEHS NIH HHS	United States	R21ES035997	PubMed	NIH RePORTER
R35 GM163544	NIGMS NIH HHS	United States	R35GM163544	PubMed	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References63

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	22,544,022	Absolute quantification of somatic DNA alterations in human cancer.	Nat Biotechnol	2012	https://conductscience.org/library/papers/22544022	PubMed
2	24,436,049	Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.	Cancer Discov	2014	https://conductscience.org/library/papers/24436049	PubMed
3	38,744,958	Systematic dissection of tumor-normal single-cell ecosystems across a thousand tumors of 30 cancer types.	Nat Commun	2024	https://conductscience.org/library/papers/38744958	PubMed
4	36,426,870	GSEApy: a comprehensive package for performing gene set enrichment analysis in Python.	Bioinformatics	2023	https://conductscience.org/library/papers/36426870	PubMed
5	31,645,765	Pan-cancer whole-genome analyses of metastatic solid tumours.	Nature	2019	https://conductscience.org/library/papers/31645765	PubMed
6	34,493,867	Genomic and evolutionary classification of lung cancer in never smokers.	Nat Genet	2021	https://conductscience.org/library/papers/34493867	PubMed
7	36,922,594	Whole-genome doubling drives oncogenic loss of chromatin segregation.	Nature	2023	https://conductscience.org/library/papers/36922594	PubMed
8	37,478,190	Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer.	Sci Adv	2023	https://conductscience.org/library/papers/37478190	PubMed
9	34,294,755	Context-dependent effects of whole-genome duplication during mammary tumor recurrence.	Sci Rep	2021	https://conductscience.org/library/papers/34294755	PubMed
10	37,046,095	The evolution of non-small cell lung cancer metastases in TRACERx.	Nature	2023	https://conductscience.org/library/papers/37046095	PubMed

1 to 10 of 63

See all 63 references

Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first.

None in this release.

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/42962034

GET https://conductscience.org/api/papers/v1/42962034/references?page=2

API reference For AI assistants