Paper · 42972081

A selective TNKS2 inhibitor for tumor-restricted WNT suppression.

Zimmerman J and 23 others. Nat Chem Biol, 2026.

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ConductScience Library. A selective TNKS2 inhibitor for tumor-restricted WNT suppression. Papers, record 42972081. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42972081

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A selective TNKS2 inhibitor for tumor-restricted WNT suppression.
Journal: Nat Chem Biol
Year: 2026
Publication types: Journal Article
PubMed: https://pubmed.ncbi.nlm.nih.gov/42972081/
DOI: https://doi.org/10.1038/s41589-026-02358-z
The journal: https://conductscience.org/library/journal-index/101231976
Revised in PubMed: 2026-11-05

Source PubMed

Authors24

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Zimmerman J	Jill
2	Malone BF	Brandon F
3	Chu K	Kevan
4	Finkin-Groner E	Efrat
5	Sun S	Shan
6	Liang R	Rui
7	Bahadur S	Sher
8	Foronda M	Miguel	https://orcid.org/0000-0001-9590-9281
9	Schatoff EM	Emma M
10	Granowsky E	Elizabeth

1 to 10 of 24Source PubMed

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Topics0

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None in this release.

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
P30 CA008748	NCI NIH HHS	United States	P30CA008748	PubMed	NIH RePORTER
R01CA273106	U.S. Department of Health & Human Services \| NIH \| NCI \| Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics)		R01CA273106	PubMed	NIH RePORTER
R35 GM156616	NIGMS NIH HHS	United States	R35GM156616	PubMed	NIH RePORTER
P30CA008748	U.S. Department of Health & Human Services \| NIH \| NCI \| Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics)		P30CA008748	PubMed	NIH RePORTER
R01 CA273106	NCI NIH HHS	United States	R01CA273106	PubMed	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References62

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	26,091,037	Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.	Cell	2015	https://conductscience.org/library/papers/26091037	PubMed
2	28,459,450	Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer.	Nat Biotechnol	2017	https://conductscience.org/library/papers/28459450	PubMed
3	31,337,618	Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.	Cancer Discov	2019	https://conductscience.org/library/papers/31337618	PubMed
4	32,546,576	Lineage Reversion Drives WNT Independence in Intestinal Cancer.	Cancer Discov	2020	https://conductscience.org/library/papers/32546576	PubMed
5	26,700,806	Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function.	Nature	2016	https://conductscience.org/library/papers/26700806	PubMed
6	26,257,057	Wnt addiction of genetically defined cancers reversed by PORCN inhibition.	Oncogene	2016	https://conductscience.org/library/papers/26257057	PubMed
7	21,949,247	Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.	Proc Natl Acad Sci U S A	2011	https://conductscience.org/library/papers/21949247	PubMed
8	14,679,305	Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion.	J Cell Sci	2004	https://conductscience.org/library/papers/14679305	PubMed
9	17,208,432	The many ways of Wnt in cancer.	Curr Opin Genet Dev	2007	https://conductscience.org/library/papers/17208432	PubMed
10	26,224,873	Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer.	Clin Cancer Res	2016	https://conductscience.org/library/papers/26224873	PubMed

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Cited by0

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None in this release.

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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