Paper · 42979076

NLRP3 signalling in NSCLC: distinguishing expression, inflammasome activation and context-dependent function.

Wang X and 6 others. Front Immunol, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. NLRP3 signalling in NSCLC: distinguishing expression, inflammasome activation and context-dependent function. Papers, record 42979076. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42979076

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: NLRP3 signalling in NSCLC: distinguishing expression, inflammasome activation and context-dependent function.
Journal: Front Immunol
Year: 2026
Publication types: Journal Article, Review
PubMed: https://pubmed.ncbi.nlm.nih.gov/42979076/
DOI: https://doi.org/10.3389/fimmu.2026.1983973
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13729371/
The journal: https://conductscience.org/library/journal-index/101560960
Revised in PubMed: 2026-11-05

Source PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Wang X	Xin
2	Zhong Y	Yangli
3	Pan B	Bin
4	Yang K	Kai
5	Tan H	Hongmei
6	Huang L	Ling
7	Li X	Xi

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
NLR Family, Pyrin Domain-Containing 3 Protein	Major topic
Inflammasomes	Major topic
Carcinoma, Non-Small-Cell Lung	Major topic
Lung Neoplasms	Major topic
Signal Transduction	Major topic
Humans
Animals
Tumor Microenvironment

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

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None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References90

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	37,866,732	NLRP3 and cancer: Pathogenesis and therapeutic opportunities.	Pharmacol Ther	2023	https://conductscience.org/library/papers/37866732	PubMed
2	35,879,417	Mitochondrial control of inflammation.	Nat Rev Immunol	2023	https://conductscience.org/library/papers/35879417	PubMed
3	39,385,035	CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.	Nature	2024	https://conductscience.org/library/papers/39385035	PubMed
4	38,782,901	Single-cell and spatial transcriptomics analysis of non-small cell lung cancer.	Nat Commun	2024	https://conductscience.org/library/papers/38782901	PubMed
5	34,217,831	Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis.	Pharmacol Res	2021	https://conductscience.org/library/papers/34217831	PubMed
6	30,365,491	NLRP3/Caspase-1 inflammasome activation is decreased in alveolar macrophages in patients with lung cancer.	PLoS One	2018	https://conductscience.org/library/papers/30365491	PubMed
7	39,930,093	Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants.	Nat Immunol	2025	https://conductscience.org/library/papers/39930093	PubMed
8	38,241,033	EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth.	Cancer Discov	2024	https://conductscience.org/library/papers/38241033	PubMed
9	41,073,787	Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer.	Nat Genet	2025	https://conductscience.org/library/papers/41073787	PubMed
10	38,898,200	Spatial iTME analysis of KRAS mutant NSCLC and immunotherapy outcome.	NPJ Precis Oncol	2024	https://conductscience.org/library/papers/38898200	PubMed

1 to 10 of 90

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Cited by0

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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