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Paper · 42983097

In vivo CAR-T double knockout screen maps synergistic antitumour gene pairs.

Zhou L and 22 others. Nature, 2026.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. In vivo CAR-T double knockout screen maps synergistic antitumour gene pairs. Papers, record 42983097. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42983097

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
In vivo CAR-T double knockout screen maps synergistic antitumour gene pairs.
Journal
Nature
Year
2026
Publication types
Journal Article
Revised in PubMed
2026-11-04

Source PubMed

Authors23

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Zhou LLiqunhttps://orcid.org/0000-0002-3561-7495
2Renauer PAPaul A
3Tang KKaiyuanhttps://orcid.org/0009-0006-4538-6519
4Li SShanshan
5Luo ZZhichenghttps://orcid.org/0009-0005-5212-3242
6Feng YYanzhi
7Lin SHShawn Hhttps://orcid.org/0000-0002-6909-467X
8Zhang FFeifei
9Park DDanielhttps://orcid.org/0009-0002-6862-6635
10Fang SYShao-Yuhttps://orcid.org/0009-0001-5474-0798

1 to 10 of 23Source PubMed

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Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References74

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
140,379,910In vivo CAR engineering for immunotherapy.Nat Rev Immunol2025https://conductscience.org/library/papers/40379910PubMed
235,570,136Mechanisms of T cell exhaustion guiding next-generation immunotherapy.Trends Cancer2022https://conductscience.org/library/papers/35570136PubMed
336,350,989Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment.Sci Transl Med2022https://conductscience.org/library/papers/36350989PubMed
435,844,304CAR T cell therapy in solid tumors: A review of current clinical trials.EJHaem2022https://conductscience.org/library/papers/35844304PubMed
531,827,283Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy.Nature2019https://conductscience.org/library/papers/31827283PubMed
636,002,574RASA2 ablation in T cells boosts antigen sensitivity and long-term function.Nature2022https://conductscience.org/library/papers/36002574PubMed
736,356,142Enhanced T cell effector activity by targeting the Mediator kinase module.Science2022https://conductscience.org/library/papers/36356142PubMed
839,663,454Central control of dynamic gene circuits governs T cell rest and activation.Nature2025https://conductscience.org/library/papers/39663454PubMed
937,776,850Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells.Immunity2023https://conductscience.org/library/papers/37776850PubMed
1029,118,008CTLA-4: a moving target in immunotherapy.Blood2018https://conductscience.org/library/papers/29118008PubMed

1 to 10 of 74

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first.

None in this release.

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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