Paper · 4355239

Letter: Accelerated substrate cycling of fructose-6-phosphate in the muscle of malignant hyperthermic pigs.

Clark MG and 6 others. Nature, 1973. Cited by 83 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Letter: Accelerated substrate cycling of fructose-6-phosphate in the muscle of malignant hyperthermic pigs. Papers, record 4355239. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4355239

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Letter: Accelerated substrate cycling of fructose-6-phosphate in the muscle of malignant hyperthermic pigs.; PubMed
Journal: Nature; PubMed
Year: 1973; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/4355239/; PubMed
DOI: https://doi.org/10.1038/245099a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 83; iCite
Relative citation ratio, by iCite: 3.25; iCite
Revised in PubMed: 2019-06-17; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Clark MG	M G
2	Williams CH	C H
3	Pfeifer WF	W F
4	Bloxham DP	D P
5	Holland PC	P C
6	Taylor CA	C A
7	Lardy HA	H A

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Fever	Major topic
Fructosephosphates	Major topic
Muscles	Major topic
Muscular Diseases	Major topic
Adenosine Triphosphate
Animals
Carbon Radioisotopes
Fructose-Bisphosphatase
Glycolysis
Halothane
Phosphofructokinase-1
Swine
Tritium

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 83 citations.

PMID	Title	Journal	Year	In Papers	Source
33,981,039	Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.	Nature	2021	https://conductscience.org/library/papers/33981039	PubMed
7,205,667	Porcine muscle responses to carbachol, alpha- and beta-adrenoceptor agonists, halothane or hyperthermia.	J Physiol	1980	https://conductscience.org/library/papers/7205667	PubMed
6,864,722	Thermogenesis in stress-susceptible pigs: a review.	J R Soc Med	1983	https://conductscience.org/library/papers/6864722	PubMed
6,842,531	Investigation of malignant hyperthermia: analysis of skeletal muscle proteins from normal and halothane sensitive pigs by two dimensional gel electrophoresis.	J Med Genet	1983	https://conductscience.org/library/papers/6842531	PubMed
6,380,496	The rate of substrate cycling between fructose 6-phosphate and fructose 1,6-bisphosphate in skeletal muscle.	Biochem J	1984	https://conductscience.org/library/papers/6380496	PubMed
3,888,661	Malignant hyperthermia: molecular defects in membrane permeability.	Experientia	1985	https://conductscience.org/library/papers/3888661	PubMed
2,453,969	Etiopathogenetic defect of malignant hyperthermia: hypersensitive calcium-release channel of skeletal muscle sarcoplasmic reticulum.	Vet Res Commun	1987	https://conductscience.org/library/papers/2453969	PubMed
2,450,656	On the analysis of substrate cycles in large metabolic systems.	Cell Biophys	1987	https://conductscience.org/library/papers/2450656	PubMed
1,252,857	Role of hypertension in fulminant hyperthermia-stress syndrome.	Br Med J	1976	https://conductscience.org/library/papers/1252857	PubMed
1,156,789	Pigs susceptible to energy metabolism in the fulminant hyperthermia stress syndrome.	Br Med J	1975	https://conductscience.org/library/papers/1156789	PubMed

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
PFKM	5,213	PubTator's text mining	https://conductscience.org/library/genes/5213

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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