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Paper · 4361995

Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.

Collier HO and 1 other. Nature, 1974. Cited by 355 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate. Papers, record 4361995. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4361995

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.
PubMed
Journal
Nature
PubMed
Year
1974
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
355
iCite
Relative citation ratio, by iCite
12.5
iCite
Revised in PubMed
2026-10-10
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Collier HOH O
2Roy ACA C

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
BrainMajor topic
Cyclic AMPMajor topic
MorphineMajor topic
Prostaglandin AntagonistsMajor topic
Adenosine Triphosphate
Animals
Heroin
In Vitro Techniques
Methadone
Morphinans
Naloxone
Rats
Tritium

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,982,431Morphine as inhibitor of prostaglandin E1 on the isolated guinea-pig intestine.Experientia1969https://conductscience.org/library/papers/4982431PubMed
25,450,435On the assay of adenyl cyclase.Anal Biochem1970https://conductscience.org/library/papers/5450435PubMed
34,584,659Prostaglandins.Monogr Endocrinol1972https://conductscience.org/library/papers/4584659PubMed
45,286,100Prostaglandin-norepinephrine interactions in brain: microelectrophoretic and histochemical correlates.Ann N Y Acad Sci1971https://conductscience.org/library/papers/5286100PubMed
54,300,679A simple, sensitive method for the assay of adenyl cyclase.J Pharmacol Exp Ther1968https://conductscience.org/library/papers/4300679PubMed
64,673,087The effect of 6-hydroxydopamine on morphine tolerance and physical dependence.J Pharmacol Exp Ther1972https://conductscience.org/library/papers/4673087PubMed
74,261,153Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation.Nature1972https://conductscience.org/library/papers/4261153PubMed
84,629,913Prostaglandins, aspirin-like drugs and analgesia.Nat New Biol1972https://conductscience.org/library/papers/4629913PubMed
94,179,885Effect of oral prostaglandin E1 on intestinal transit in man.Lancet1969https://conductscience.org/library/papers/4179885PubMed
105,315,411Prostaglandins and neuronal activity in spinal and cuneate nucleus.Ann N Y Acad Sci1971https://conductscience.org/library/papers/5315411PubMed

1 to 10 of 37

See all 37 references

Cited by57

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 355 citations.

PMIDTitleJournalYearIn PapersSource
38,390,618Contributions of the International Narcotics Research Conference to Opioid Research Over the Past 50 years.Adv Drug Alcohol Res2022https://conductscience.org/library/papers/38390618PubMed
38,028,425The opioid receptor: emergence through millennia of pharmaceutical sciences.Front Pain Res (Lausanne)2023https://conductscience.org/library/papers/38028425PubMed
33,704,603Synthesis of the Mechanisms of Opioid Tolerance: Do We Still Say NO?Cell Mol Neurobiol2021https://conductscience.org/library/papers/33704603PubMed
25,009,497Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment.Front Pharmacol2014https://conductscience.org/library/papers/25009497PubMed
24,271,240The opiate receptors.Neurochem Res1976https://conductscience.org/library/papers/24271240PubMed
24,076,545Mu opioids and their receptors: evolution of a concept.Pharmacol Rev2013https://conductscience.org/library/papers/24076545PubMed
21,598,037Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format.Cell Mol Neurobiol2011https://conductscience.org/library/papers/21598037PubMed
20,147,620Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway.Proc Natl Acad Sci U S A2010https://conductscience.org/library/papers/20147620PubMed
19,337,273Capturing adenylyl cyclases as potential drug targets.Nat Rev Drug Discov2009https://conductscience.org/library/papers/19337273PubMed
18,799,742Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.Proc Natl Acad Sci U S A2008https://conductscience.org/library/papers/18799742PubMed

1 to 10 of 57

See all 57 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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